公开(公告)号：ES2114984T3

公开(公告)日：1998-06-16

申请号：ES93113731

申请日：1993-08-27

Applicant: BASF AG

Inventor： PAUST JOACHIM DR ,  ECKES PETER DR ,  SIEGEL WOLFGANG DR ,  BALKENHOHL FRIEDHELM DR ,  DOBLER WALTER DR ,  HULLMANN MICHAEL DR

IPC: C07C323/52 ,  C07C67/00 ,  C07C69/06 ,  C07C69/708 ,  C07C319/08 ,  C07D339/04

公开(公告)号：DE4435421A1

公开(公告)日：1996-04-11

申请号：DE4435421

申请日：1994-10-04

Applicant: BASF AG

Inventor： KRAUSE WOLFGANG DR ,  ERNST HANSGEORG DR ,  PAUST JOACHIM DR ,  RHEUDE UDO DR ,  DOBLER WALTER DR

IPC: C07C67/307 ,  C07C69/65 ,  C07F9/40

Abstract: Prodn. of trialkyl 4-phosphono-2-methyl-2-butenoate esters of formula (I) with a high E-isomer content comprises (a) reacting an alkyl 2-hydroxy-2-methyl-3-butenoate of formula (II) with PBr3 or PCl3 at 0-80 degrees C in the absence of pyridine to form a mixt. of an alkyl 4-halo-2- methyl-2-butenoate of formula (III) and an alkyl 2-halo-2-methyl-3-butenoate of formula (IV), and (b) reacting the mixt. with a trialkyl phosphite of formula (V) at 70-140 degrees C. R1, R2 = Me or Et; X = Cl or Br. Also claimed is the prodn. of (III) as in step (a) above at a temp. of 20-80 degrees C.

公开(公告)号：FR2709490A1

公开(公告)日：1995-03-10

申请号：FR9410366

申请日：1994-08-29

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  PAUST JOACHIM DR ,  DOBLER WALTER DR ,  RHEUDE UDO DR

IPC: C07C403/16 ,  C07C47/21 ,  C07C69/66 ,  C07C403/00 ,  C07C403/24 ,  C07F9/50 ,  C07F9/54 ,  C07C49/325

Abstract: Process for the preparation of astaxanthin by reaction of the tertiary alcohol of formula II or of the diacetate of formula III in an inert solvent with aqueous hydrochloric acid or hydrobromic acid, which gives a halide which is converted, by reaction with triphenylphosphine, to a triphenylphosphonium salt which is reacted, according to a Wittig reaction, with 2,7-dimethyl-2,4,6-octatriene-1,8-dial. By carrying out the reaction of the halide with triphenylphosphine in an acyclic lower dialkyl ether, the triphenylphosphonium salt is obtained in a highly crystalline form which makes isolation easier and which improves the yields.

公开(公告)号：DE58901065D1

公开(公告)日：1992-05-07

申请号：DE58901065

申请日：1989-03-22

Applicant: BASF AG

Inventor： DOBLER WALTER DR ,  EGGERSDORFER MANFRED DR ,  PAUST JOACHIM DR

IPC: C07D475/14 ,  C07F9/547 ,  C07F9/6561

Abstract: Process for the purification of salts of riboflavin 5'-phosphate obtained by phosphorylation of riboflavin and reaction of the riboflavin 5'-phosphate (5'-FMN) contaminated with unreacted riboflavin and isomeric riboflavin monophosphates and diphosphates and formed in this process with alkali metal hydroxides or nitrogen bases, which is characterised in that a) an approximately 1 to 15% strength by weight homogeneous, clear, aqueous 5'-FMN salt solution having a pH from 4 to 7 is prepared from the crude 5'-FMN obtained in the phosphorylation, water, and the alkali metal hydroxide or the nitrogen base, preferably sodium hydroxide solution, optionally with warming at 30 to 100 DEG C, b) the solution obtained is treated with a suitable polymeric adsorber resin and c) the 5'-FMN salt largely purified of unreacted riboflavin is isolated from the solution obtained in this process and, if desired, the solution is submitted to a subsequent fine purification. The treatment with the suitable polymeric adsorber resin is advantageously carried out in a column packed with adsorber resin. The subsequent fine purification can be carried out by means of crystallisation by evaporation or by chromatography of a 5'-FMN solution containing 1 to 15% by weight of dry material in water or a mixture of water and a lower aliphatic alcohol having a pH between 4 and 7 in a minimum amount of 5 to 50% of the bed volume of the column on RP silica gel derivatised with alkyl groups using water or a mixture of water and a lower aliphatic alcohol as the eluent. The preparative chromatography of 5'-FMN salts on derivatised RP silica gel with water or a mixture of water and a lower aliphatic alcohol as the solvent and eluent is also claimed independently of the pretreatment with the suitable adsorber resin.

公开(公告)号：DE3906632A1

公开(公告)日：1990-09-06

申请号：DE3906632

申请日：1989-03-02

Applicant: BASF AG

Inventor： DOBLER WALTER DR ,  SCHUL WOLFGANG DR ,  PAUST JOACHIM DR ,  MITSCHKER ALFRED DR

IPC: C07F9/6558 ,  G01N30/02

Abstract: In a process for separating thiamine monophosphate from a solution of thiamine phosphates, the solution of thiamine phosphates, which contains the thiamine monophosphate and cocarboxylase is used at a pH of 2 to 7 and a cationic exchanger resin is used having a pKa of 1.0 to 4.5.

公开(公告)号：DE3837954A1

公开(公告)日：1990-05-10

申请号：DE3837954

申请日：1988-11-09

Applicant: BASF AG

Inventor： HERMELING DIETER DR ,  BECKER RAINER DR ,  DOBLER WALTER DR

IPC: C07C49/17 ,  C25B3/29

Abstract: Method for the preparation of dihydroxydiones of the general formula R-CO-CH(OH)-CH(OH)-CO-R I in which R stands for an alkyl radical, in which an aldehyde of the general formula in which R has the abovementioned meaning, is electrolysed in a water- containing electrolyte which has a pH of less than 7.

公开(公告)号：DE19624828C1

公开(公告)日：1998-03-26

申请号：DE19624828

申请日：1996-06-21

Applicant: BASF AG

Inventor： SUELING CARSTEN DR ,  GREGORIUS HEIKE DR ,  DOBLER WALTER DR ,  HINGMANN ROLAND DR ,  RIEGER BERNHARD PROF ,  MUELLER HANS-JOACHIM DR ,  WAGNER JUERGEN MATTHAEUS DR ,  DIETRICH ULF

IPC: C07C45/46 ,  C07C49/675

Abstract: A process for preparing a compound of the formula Iwhere R1 and R2 are hydrogen or C1-C4-alkyl and R3 is C1-C10-alkyl, phenyl or C1-C4-alkyl-substituted phenyl, comprises reacting a compound IIwith a compound of the formula IIIwhere X is chlorine, bromine or iodine, in the presence of a Friedel-Crafts catalyst in one step to give a compound I.

公开(公告)号：DE4424294A1

公开(公告)日：1996-01-11

申请号：DE4424294

申请日：1994-07-09

Applicant: BASF AG

Inventor： DOBLER WALTER DR ,  KRAUSE WOLFGANG DR ,  PAUST JOACHIM DR ,  WOERZ OTTO DR ,  RHEUDE UDO DR ,  BURST WOLFRAM ,  DAEUWEL GUENTER ,  BERTRAM ARMIN ,  SCHULZ BERNHARD DR ,  WEGNER GUENTER DR

IPC: A23L5/40 ,  C07B41/04 ,  C07B41/08 ,  C07C45/72 ,  C07C67/347 ,  C07C291/04 ,  C07C403/14 ,  C07C403/20 ,  C07D207/46 ,  C07D211/94 ,  C07D263/04 ,  C07D521/00 ,  C09B23/01

Abstract: Prodn. of polyenecarbonyl cpds. (I) having high all-E content, and their acetals and ketals, comprises reacting a carbonyl cpd. (II) with a dialkyl phosphonate in a Horner-Emmons reaction or with a CH-acidic cpd. in an aldol condensation in the presence of 0.3-10 mol.% (based on (II)) of a component (B) comprising a) oxygen or nitrogen monoxide (opt. mixed with an inert gas); b) the stable 2,2-diphenyl-1-picrylhydrazyl radical or a hydrogen peroxide-urea adduct; c) quinone, a quinone deriv. or coenzyme Q10 hydroquinone; and/or d) a stable radical of formula (I) or (II). R1, R2 = 1-4C alkyl; or R1+R2 = ethylene, propylene, vinylene or propenylene (all opt. substd. by alkyl, aryl, OH, alkoxy, silyloxy, oxo, NH2, SH, alkylthio, CN, COOH, carbamoyl, heteroaryl or alkylcarbonyloxy); R3-R5 = as R1, R2.

公开(公告)号：FR2709490B3

公开(公告)日：1995-10-27

申请号：FR9410366

申请日：1994-08-29

Applicant: BASF AG

Inventor： ERNST HANSGEORG DR ,  PAUST JOACHIM DR ,  DOBLER WALTER DR ,  RHEUDE UDO DR

IPC: C07C403/16 ,  C07C47/21 ,  C07C69/66 ,  C07C403/00 ,  C07C403/24 ,  C07F9/50 ,  C07F9/54 ,  C07C49/325

公开(公告)号：DE59009263D1

公开(公告)日：1995-07-27

申请号：DE59009263

申请日：1990-02-26

Applicant: BASF AG

Inventor： DOBLER WALTER DR ,  SCHUL WOLFGANG DR ,  PAUST JOACHIM DR ,  MITSCHKER ALFRED DR

IPC: C07F9/6558 ,  G01N30/02

Abstract: In a process for separating thiamine monophosphate from a solution of thiamine phosphates, the solution of thiamine phosphates, which contains the thiamine monophosphate and cocarboxylase is used at a pH of 2 to 7 and a cationic exchanger resin is used having a pKa of 1.0 to 4.5.