公开(公告)号：BR0213878A

公开(公告)日：2004-08-31

申请号：BR0213878

申请日：2002-10-25

Applicant: BASF AG

Inventor： EINING HEINZ ,  LLER BERND W M ,  RASENACK NORBERT ,  FRIESE KATRIN ,  FRANKE DIRK

IPC: A61K9/20 ,  A61K9/14 ,  A61K9/16 ,  A61K9/26 ,  A61K31/192 ,  A61P29/00 ,  C07C51/43 ,  C07C51/50 ,  C07C57/30 ,  C07C59/64

Abstract: The present invention relates to a process for the formation of profen crystals, which comprises carrying out the formation of solids by displacement precipitation, cooling crystallization, evaporative crystallization or a combination thereof in the presence of one or more additives, and the use of the profens thus prepared for pharmaceutical formulations.