公开(公告)号：ZA9805867B

公开(公告)日：2000-01-10

申请号：ZA9805867

申请日：1998-07-03

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  BLANK STEFAN ,  TREIBER HANS-JOERG ,  NEUMANN-SCHULTZ LILIANE UNGER ,  BRIS THEOPHILE-MARIE LE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D ,  A61K

CPC classification number: C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：NO20000048L

公开(公告)日：2000-01-06

申请号：NO20000048

申请日：2000-01-06

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  BLANK STEFAN ,  TREIBER HANS-JOERG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ ,  BRIS THEOPHILE-MARIE LE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

公开(公告)号：ZA9805121B

公开(公告)日：1999-12-13

申请号：ZA9805121

申请日：1998-06-12

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ

IPC: A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/04 ,  C07D ,  A61K

CPC classification number: C07D495/04

公开(公告)号：ZA9805120B

公开(公告)日：1999-12-13

申请号：ZA9805120

申请日：1998-06-12

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ

IPC: A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/14 ,  C07D ,  A61K

CPC classification number: C07D495/14

公开(公告)号：GR3030371T3

公开(公告)日：1999-09-30

申请号：GR990401463

申请日：1999-05-28

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: PCT No. PCT/EP95/02781 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02520 PCT Pub. Date Feb. 1, 1996The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：HU9901590A2

公开(公告)日：1999-08-30

申请号：HU9901590

申请日：1997-01-10

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TESCHENDORF HANS-JUERGEN ,  TREIBER HANS-JOERG ,  UNGER LILIANE ,  WICKE KARSTEN

IPC: C07D243/08 ,  A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/18 ,  A61P43/00 ,  C07D213/73 ,  C07D223/04 ,  C07D245/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: Aza- and diazacyclohexane and -cyclooctane compounds of the following formula:where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：DK0592453T3

公开(公告)日：1999-08-23

申请号：DK92908760

申请日：1992-05-11

Applicant: BASF AG

Inventor： TESCHENDORF HANS-JUERGEN ,  RENDENBACH-MUELLER BEATRICE ,  UNGER LILIANE

IPC: A61K31/395 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/41 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/12 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P43/00 ,  C07D285/12 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: PCT No. PCT/EP92/01028 Sec. 371 Date Dec. 13, 1993 Sec. 102(e) Date Dec. 13, 1993 PCT Filed May 11, 1992 PCT Pub. No. WO92/22541 PCT Pub. Date Dec. 23, 1992.Aminoalkyl-substituted 2-amino-1,3,4-thiadiazoles of the formula I where n and A have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：FI103667B1

公开(公告)日：1999-08-13

申请号：FI935399

申请日：1993-12-02

Applicant: BASF AG

Inventor： STEINER GERD ,  UNGER LILIANE ,  BEHL BERTHOLD ,  TESCHENDORF HANS-JUERGEN

IPC: A61K31/40 ,  C07D20060101 ,  C07D209/52

公开(公告)号：DK0589903T3

公开(公告)日：1999-06-07

申请号：DK92909823

申请日：1992-05-08

Applicant: BASF AG

Inventor： RENDENBACH-MUELLER BEATRICE ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: A61K31/435 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61P9/12 ,  A61P25/16 ,  A61P25/18 ,  C07D277/20 ,  C07D277/40 ,  C07D277/54 ,  C07D417/12 ,  C07D417/14

Abstract: PCT No. PCT/EP92/01004 Sec. 371 Date Dec. 13, 1993 Sec. 102(e) Date Dec. 13, 1993 PCT Filed May 8, 1992 PCT Pub. No. WO92/22540 PCT Pub. Date Dec. 23, 1992.Aminoalkyl-substituted 5-mercaptothiazoles of the formula where R1, n and A have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：NO991132D0

公开(公告)日：1999-03-09

申请号：NO991132

申请日：1999-03-09

Applicant: BASF AG

Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  BEHL BERTHOLD ,  KERRIGAN FRANK ,  CHEETHAM SHARON

IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14 ,  C07D221/00

Abstract: A 3-substituted 3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine compound of formula IwhereinR1 is hydrogen, C1-C4-alkyl, acetyl or benzoyl, optionally substituted phenyl-C1-C4-alkyl, naphthyl-C1-C3-alkyl, phenyl-C2-C3-alkanone or a phenylcarbamoyl-C2-alkyl,R2 is optionally substituted phenyl, pyridyl, pyrimidyl or pyrazinyl, or an optionally substituted bicyclus wherein one of the two fused rings is a phenyl, a pyridyl, a pyrimidyl or a pyrazinyl ring,A is NH or oxygen,B is hydrogen or methyl,C is hydrogen, methyl or hydroxyl,X is nitrogen,Y is CH2, CH2-C2, CH2-C2-CH2 or CH2-CH,Z is nitrogen, C or CH, and the linkage between Y and Z is a single or a double bond, andn is 2, 3 or 4,or a physiologically tolerated salt thereof, and compositions comprising them and their use as antagonists of 5HT1B and 5HT1A and for the treatment of depression and related disorders.