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公开(公告)号:CA2005060A1
公开(公告)日:1990-06-12
申请号:CA2005060
申请日:1989-12-11
Applicant: BASF AG
Inventor: BOEHM HANS-JOACHIM , DAUM LOTHAR , HAUPT ANDREAS , SCHMIED BERNHARD , WALKER NIGEL , ZECHEL JOHANN-CHRISTIAN
IPC: A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/00 , C07K14/52 , C07K14/525 , A61K38/08 , A61K38/12 , A61K38/19 , C07K7/50
Abstract: Peptides of the formula X-A-B-Tyr-Y, where A, B, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.
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公开(公告)号:CA2005059A1
公开(公告)日:1990-06-12
申请号:CA2005059
申请日:1989-12-11
Applicant: BASF AG
Inventor: BOEHM HANS-JOACHIM , DAUM LOTHAR , HAUPT ANDREAS , SCHMIED BERNHARD , WALKER NIGEL , ZECHEL JOHANN-CHRISTIAN
IPC: A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K7/06 , C07K7/08 , C07K7/56 , C07K7/64 , C07K14/00 , C07K14/52 , C07K14/525 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/19 , C07K7/50
Abstract: Peptides of the formula X-A-Y, where A, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.
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公开(公告)号:CA2005057A1
公开(公告)日:1990-06-12
申请号:CA2005057
申请日:1989-12-11
Applicant: BASF AG
Inventor: BOEHM HANS-JOACHIM , DAUM LOTHAR , HAUPT ANDREAS , SCHMIED BERNHARD , WALKER NIGEL , ZECHEL JOHANN-CHRISTIAN
IPC: A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/00 , C07K14/52 , C07K14/525 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/19 , C07K7/50
Abstract: Peptides of the formula X-A-Y, where A, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.
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公开(公告)号:CA2005052A1
公开(公告)日:1990-06-12
申请号:CA2005052
申请日:1989-12-11
Applicant: BASF AG
Inventor: BOEHM HANS-JOACHIM , DAUM LOTHAR , HAUPT ANDREAS , SCHMIED BERNHARD , WALKER NIGEL , ZECHEL JOHANN-CHRISTIAN
IPC: A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K1/04 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/00 , C07K14/52 , C07K14/525 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/19 , C07K7/50
Abstract: Peptides of the formula X-A-B-E-Leu-Y, where A, B, E, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.
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公开(公告)号:AU742746B2
公开(公告)日:2002-01-10
申请号:AU4817297
申请日:1997-10-09
Applicant: WARNER LAMBERT CO , BASF AG
Inventor: ALLEN HAMISH JOHN , BRADY KENNETH DALE , HARTER WILLIAM GLEN , LUNNEY ELIZABETH ANN , PLUMMER MARK STEPHEN , SAWYER TOMI , SHAHRIPOUR AURASH , WALKER NIGEL
IPC: A61K31/192 , A61K31/341 , A61P1/00 , A61P7/08 , A61P19/02 , A61P25/28 , A61P31/04 , C07C311/19 , C07C311/29 , C07C311/46 , C07C323/67 , C07D307/12 , C07C311/00
Abstract: PCT No. PCT/US97/18406 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 9, 1997 PCT Pub. No. WO98/16504 PCT Pub. Date Apr. 23, 1998The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have the Formula I, II, or III. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme.
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公开(公告)号:AU736694B2
公开(公告)日:2001-08-02
申请号:AU4753897
申请日:1997-10-09
Applicant: WARNER LAMBERT CO , BASF AG
Inventor: ALBRECHT HANS P , ALLEN HAMISH JOHN , BRADY KENNETH DALE , HARTER WILLIAM GLEN , KOSTLAN CATHERINE ROSE , ROTH BRUCE DAVID , WALKER NIGEL
IPC: A61K31/195 , A61K31/473 , A61K38/00 , A61P9/00 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/00 , A61P43/00 , C07C311/06 , C07C311/10 , C07C311/13 , C07C311/19 , C07D217/24 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/078 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/103 , C07K5/107 , C07K5/11 , C07K5/113 , C07K5/117 , C07C311/24 , C07K5/062 , A61K31/18
Abstract: The present invention relates to compounds that are inhibitors of interleukin-1beta converting enzyme that have the Formula (I). This invention also relates to a method of treatment of stroke, reperfusion injury, Alzheimer's disease, shigellosis, inflammatory diseases, and septic shock and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1beta converting enzyme.
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公开(公告)号:AU1073001A
公开(公告)日:2001-04-23
申请号:AU1073001
申请日:2000-10-04
Applicant: BASF AG
Inventor: TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
IPC: A61K38/00 , C07C309/24 , C07D307/85 , C07F9/38 , C07K5/02 , C07K5/113 , C12N9/16
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公开(公告)号:CA2383603A1
公开(公告)日:2001-03-08
申请号:CA2383603
申请日:2000-08-25
Applicant: GPC BIOTECH INC , BASF AG
Inventor: BOCKOVICH NICHOLAS , ECKSTEIN JENS , BORHANI DAVID , FUJIMORI TARO , PAL KOLLOL , RITTER KURT , ROBINSON SIMON , HEDIGER MARK , HAUPT ANDREAS , RUDOLPH JOHANNES , COME JON , DIXON RICHARD W , CHOQUETTE DEBORAH , EPSTEIN DAVID , KLUGE ARTHUR , WALKER NIGEL , BLANCHARD JILL , TAYLOR NEIL R
IPC: C12N15/09 , A61K38/00 , A61K45/00 , A61P9/08 , A61P29/00 , A61P35/00 , A61P43/00 , C07K5/10 , C07K5/107 , C12N9/16 , C12N9/99 , C12N15/55 , A61K38/43
Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of t he catalytic domain of Cdc25. The invention also relates to the use of the thre e dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.
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公开(公告)号:PL332704A1
公开(公告)日:1999-09-27
申请号:PL33270497
申请日:1997-10-09
Applicant: WARNER LAMBERT CO , BASF AG
Inventor: ALLEN HAMISH JOHN , BRADY KENNETH DALE , HARTER WILLIAM GLEN , LUNNEY ELIZABETH ANN , PLUMMER MARK STEPHEN , SAWYER TOMI , SHAHRIPOUR AURASH , WALKER NIGEL
IPC: A61K31/192 , A61K31/341 , A61P1/00 , A61P7/08 , A61P19/02 , A61P25/28 , A61P31/04 , C07C311/19 , C07C311/29 , C07C311/46 , C07C323/67 , C07D307/12 , C07C311/42 , A61K31/195 , A61K31/34
Abstract: PCT No. PCT/US97/18406 Sec. 371 Date Apr. 9, 1999 Sec. 102(e) Date Apr. 9, 1999 PCT Filed Oct. 9, 1997 PCT Pub. No. WO98/16504 PCT Pub. Date Apr. 23, 1998The present invention relates to compounds that are inhibitors of interleukin-1 beta converting enzyme that have the Formula I, II, or III. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock reperfusion injury, Alzheimer's disease, and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an inhibitor of interleukin-1 beta converting enzyme.
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公开(公告)号:NO991677A
公开(公告)日:1999-06-09
申请号:NO991677
申请日:1999-04-09
Applicant: WARNER LAMBERT CO , BASF AG
Inventor: ALBRECHT HANS-PETER , ALLEN HAMISH JOHN , BRADY KENNETH DALE , CAPRATHE BRADLEY WILLIAM , GILMORE JOHN LODGE , HARTER WILLIAM GLEN , HAYS SHERYL JEANNE , KOSTLAN CATHERINE ROSE , LUNNEY ELIZABETH ANN , PARA KIMBERLY SUZANNE , THOMAS ANTHONY JEROME , WALKER NIGEL
IPC: C07D233/34 , A61K31/22 , A61K31/222 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/405 , A61K31/4164 , A61K31/4166 , A61K31/428 , A61K31/44 , A61K31/4409 , A61K31/4412 , A61K31/472 , A61K31/505 , A61K38/00 , A61P1/00 , A61P25/28 , A61P29/00 , A61P31/10 , A61P43/00 , C07C233/47 , C07C233/50 , C07C233/51 , C07C271/22 , C07C275/16 , C07C275/60 , C07C311/03 , C07C311/06 , C07C311/19 , C07C317/04 , C07C317/44 , C07C323/52 , C07C327/32 , C07D207/08 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/28 , C07D207/48 , C07D209/08 , C07D209/18 , C07D211/34 , C07D211/76 , C07D211/96 , C07D213/55 , C07D213/75 , C07D217/24 , C07D233/36 , C07D233/64 , C07D239/10 , C07D277/64 , C07D307/68 , C07D307/79 , C07D307/80 , C07D333/22 , C07D333/24 , C07D333/38 , C07D333/54 , C07D333/60 , C07K5/00 , C07K5/02 , C07K5/093
CPC classification number: C07D207/08 , A61K38/00 , C07C233/47 , C07C233/51 , C07C271/22 , C07C275/16 , C07C311/03 , C07C311/06 , C07C311/19 , C07C317/04 , C07C317/44 , C07C323/52 , C07C327/32 , C07C2601/10 , C07C2602/10 , C07C2602/42 , C07D207/27 , C07D207/28 , C07D209/08 , C07D209/18 , C07D211/34 , C07D211/76 , C07D213/55 , C07D213/75 , C07D217/24 , C07D233/36 , C07D239/10 , C07D307/79 , C07D333/24 , C07D333/38 , C07D333/54 , C07K5/0202
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