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公开(公告)号：WO0116300A3
公开(公告)日：2002-05-30
申请号：PCT/US0023473
申请日：2000-08-25
Applicant: BASF AG , GPC BIOTECH INC , TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
Inventor： TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
IPC: C12N15/09 , A61K38/00 , A61K45/00 , A61P9/08 , A61P29/00 , A61P35/00 , A61P43/00 , C07K5/10 , C07K5/107 , C12N9/16 , C12N9/99 , C12N15/55 , C07K7/06 , C30B29/58 , G06F17/50
CPC classification number: C07K5/1016 , A61K38/00 , C07K5/1027 , C12N9/16
Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.
Abstract translation: 本发明涉及包含Cdc25的配体结合结构域，这些多肽的结晶形式以及这些结晶形式用于确定Cdc25催化结构域的三维结构的多肽。 本发明还涉及Cdc25催化结构域的三维结构在设计和/或鉴定Cdc25活性的潜在抑制剂的方法中的用途，例如抑制天然底物与Cdc25催化结构域结合的化合物。
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2.发明申请HYDROXYSULFONYLALKYLENE-, PHOSPHONOALKYLENE- OR DIFLUORO(PHOSPHONONON)METHYL- SUBSTITUTED BENZENE, OR BENZOFURAN DERIVATIVES AS NON-PEPTIDIC CDC25 INHIBITORS 审中-公开羟基甲基戊烯，磷酸二甲酯或二氟（膦酰）甲基取代的苯甲腈或苯并呋喃衍生物作为非肽性CDC25抑制剂
公开(公告)号：WO0127077A3
公开(公告)日：2002-05-23
申请号：PCT/US0027361
申请日：2000-10-04
Applicant: BASF AG , TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
Inventor： TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
IPC: A61K38/00 , C07C309/24 , C07D307/85 , C07F9/38 , C07K5/02 , C07K5/113 , C12N9/16 , A61K31/185 , A61K31/343 , A61K31/662
CPC classification number: C12N9/16 , A61K38/00 , C07C309/24 , C07D307/85 , C07F9/3882 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/1021 , C07K2299/00
Abstract: The present application relates to compounds of the fornula (VII), wherein the substituents R -R , X and Y are as defined in the description and to compounds of formula (VIII) or formula (IX) and when R is in the ortho position to X, R and R are taken together with the atoms to which are each attached to form an aromatic heterocyclic ring. The application further relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.
Abstract translation: 本申请涉及式（VII）的化合物，其中取代基R 1 -R 5，X和Y如说明书和式（VIII）或式（IX）的化合物所定义，并且当 R 3位于X的邻位，R 3和R 4与各自连接的原子一起形成芳族杂环。 本申请还涉及包含Cdc25的配体结合结构域，这些多肽的结晶形式以及这些结晶形式用于确定Cdc25催化结构域的三维结构的多肽。 本发明还涉及Cdc25催化结构域的三维结构在设计和/或鉴定Cdc25活性的潜在抑制剂的方法中的用途，例如抑制天然底物与Cdc25催化结构域结合的化合物。
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公开(公告)号：ZA969402B
公开(公告)日：1998-05-08
申请号：ZA969402
申请日：1996-11-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MUELLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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公开(公告)号：NO982100A
公开(公告)日：1998-05-08
申请号：NO982100
申请日：1998-05-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MUELLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
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公开(公告)号：CZ139198A3
公开(公告)日：1998-09-16
申请号：CZ139198
申请日：1996-10-30
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MULLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , DE ARRUDA MONIKA , ROBINSON SIMON
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：AU1073001A
公开(公告)日：2001-04-23
申请号：AU1073001
申请日：2000-10-04
Applicant: BASF AG
Inventor： TAYLOR NEIL R , BORHANI DAVID , EPSTEIN DAVID , RUDOLPH JOHANNES , RITTER KURT , FUJIMORI TARO , ROBINSON SIMON , ECKSTEIN JENS , HAUPT ANDREAS , WALKER NIGEL , DIXON RICHARD W , CHOQUETTE DEBORAH , BLANCHARD JILL , KLUGE ARTHUR , PAL KOLLOL , BOCKOVICH NICHOLAS , COME JON , HEDIGER MARK
IPC: A61K38/00 , C07C309/24 , C07D307/85 , C07F9/38 , C07K5/02 , C07K5/113 , C12N9/16
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公开(公告)号：CA2383603A1
公开(公告)日：2001-03-08
申请号：CA2383603
申请日：2000-08-25
Applicant: GPC BIOTECH INC , BASF AG
Inventor： BOCKOVICH NICHOLAS , ECKSTEIN JENS , BORHANI DAVID , FUJIMORI TARO , PAL KOLLOL , RITTER KURT , ROBINSON SIMON , HEDIGER MARK , HAUPT ANDREAS , RUDOLPH JOHANNES , COME JON , DIXON RICHARD W , CHOQUETTE DEBORAH , EPSTEIN DAVID , KLUGE ARTHUR , WALKER NIGEL , BLANCHARD JILL , TAYLOR NEIL R
IPC: C12N15/09 , A61K38/00 , A61K45/00 , A61P9/08 , A61P29/00 , A61P35/00 , A61P43/00 , C07K5/10 , C07K5/107 , C12N9/16 , C12N9/99 , C12N15/55 , A61K38/43
Abstract: The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of t he catalytic domain of Cdc25. The invention also relates to the use of the thre e dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.
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公开(公告)号：BR9611383A
公开(公告)日：1999-01-26
申请号：BR9611383
申请日：1996-10-30
Applicant: BASF AG
Inventor： RITTER KURT , BERNARD HARALD , HAUPT ANDREAS , AMBERG WILHELM , BUSCHMANN ERNST , JANSSEN BERND , MUELLER STEFAN , KLING ANDREAS , ROBINSON SIMON , ARRUDA MONIKA DE , BARLOZZARI TERESA , ZIERKE THOMAS
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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公开(公告)号：NO982100L
公开(公告)日：1998-05-08
申请号：NO982100
申请日：1998-05-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MUELLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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公开(公告)号：HU9900089A2
公开(公告)日：1999-05-28
申请号：HU9900089
申请日：1996-10-30
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , DE ARRUDA MONIKA , HAUPT ANDREAS , JANSSEN BERND , KLING ANDREAS , MUELLER STEFAN , RITTER KURT , ROBINSON SIMON , ZIERKE THOMAS
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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