公开(公告)号：EP1001937B1

公开(公告)日：2003-06-11

申请号：EP98941368.7

申请日：1998-07-20

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： WINGERT, Horst ,  GÖTZ, Norbert ,  KEIL, Michael ,  KLINTZ, Ralf ,  VOGELBACHER, Uwe, Josef ,  WAHL, Josef

IPC: C07D231/08 ,  C07B39/00

CPC classification number: C07D231/08 ,  C07C201/12 ,  C07C205/11

Abstract: The invention relates to a method for producing 2-(3-pyrazolyl-oxymethylene) nitrobenzene derivatives of formula (I), wherein the substituents and indices have the meaning given in the Description, by bromination of an o-nitrotoluene of formula (II) and subsequent reaction with a 3-hydroxypyrazol of formula (IV).

公开(公告)号：EP0946514A1

公开(公告)日：1999-10-06

申请号：EP97953736.0

申请日：1997-12-04

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： VOGELBACHER, Uwe, Josef ,  KEIL, Michael ,  KLINTZ, Ralf ,  WAHL, Joseph ,  WINGERT, Horst ,  KÖNIG, Hartmann ,  RACK, Michael ,  GÖTZ, Roland ,  TELES, Joaquim, Henrique

IPC: C07D231

CPC classification number: C07D231/22 ,  C07D231/20

Abstract: The invention relates to a method for producing n-substituted 3-hydroxypyrazoles of formula (I), wherein R1 stands for optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heteroaryl and R?2 and R3¿ mean hydrogen, cyano, halogen and optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heteroaryl, by oxidizing a corresponding pyrazolidin-3-ons.

公开(公告)号：EP0765304B1

公开(公告)日：1999-08-11

申请号：EP95921761.3

申请日：1995-05-26

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： BAYER, Herbert ,  ISAK, Heinz ,  WINGERT, Horst ,  SAUTER, Hubert ,  KEIL, Michael ,  NETT, Markus ,  BENOIT, Remy ,  MÜLLER, Ruth

IPC: C07C67/22 ,  C07C249/08 ,  C07C249/12 ,  C07C251/48 ,  C07C69/738 ,  C07C251/60 ,  C07C235/78 ,  C07D249/12

CPC classification number: C07D249/12 ,  C07C67/22 ,  C07C235/78 ,  C07C249/08 ,  C07C249/12 ,  C07C251/48 ,  C07C251/60 ,  C07C69/738

公开(公告)号：EP1863752A1

公开(公告)日：2007-12-12

申请号：EP06725104.1

申请日：2006-03-16

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： RACK, Michael ,  SMIDT, Sebastian, Peer ,  BUDICH, Manuel ,  MAYWALD, Volker ,  KEIL, Michael ,  WOLF, Bernd

IPC: C07C51/08 ,  C07C63/70 ,  C07C17/23 ,  C07C17/363 ,  C07C25/13

CPC classification number: C07C25/13 ,  C07C17/23 ,  C07C17/363 ,  C07C51/08 ,  C07C63/68

Abstract: The invention relates to a method for producing 5-halo-2,4,6-trifluoroisophthalic acid of formula (I), wherein X represents F, Cl, Br, or I, by hydrolysis of 5-halo-2,4,6-trifluoroisophthalodinitrile of formula (II). Said invention is characterised in that in a first step, isophthalodinitrile (II) or a solution containing isophthalodinitrile (II) is reacted with a concentrated sulphuric acid at room temperature in order to form a 5-haIo-2,4,6-trifluoroisophthalodiamide of general formula (III), and is, subsequently, heated and in a second step, isophthalic acid (I) is produced after additional heating and addition of water.

Abstract translation: 本发明涉及通过5-卤代-2,4,6,6-四氢吡啶的水解制备式（I）的5-卤代-2,4,6-三氟间苯二甲酸的方法，其中X代表F，Cl，Br或I （II）的三氟间苯二甲腈。 所述发明的特征在于，在第一步中，异佛尔酮二腈（II）或含有间苯二甲腈（II）的溶液在室温下与浓硫酸反应，以形成5-卤-2,4,6-三氟间苯二甲酰二胺 通式（III），随后加热，并且在第二步中，间苯二甲酸（I）在额外加热和加入水之后生成。

公开(公告)号：EP1077955B1

公开(公告)日：2007-06-27

申请号：EP99922160.9

申请日：1999-05-04

Applicant: BASF Aktiengesellschaft

Inventor： RHEINHEIMER, Joachim ,  VON DEYN, Wolfgang ,  GEBHARDT, Joachim ,  RACK, Michael ,  LOCHTMAN, Rene ,  GÖTZ, Norbert ,  KEIL, Michael ,  WITSCHEL, Matthias ,  HAGEN, Helmut ,  MISSLITZ, Ulf ,  BAUMANN, Ernst

IPC: C07D261/04 ,  C07D413/10 ,  C07C251/40 ,  C07C319/14

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: The invention relates to a method for producing isoxazolene of the formula (I), where the substituents have the following meanings: R1 is hydrogen, C¿1?-C6 alkyl, R?2 is C¿1-C6 alkyl, R?3, R4, R5¿ are hydrogen, C¿1?-C6 alkyl or R?4 and R5¿ together form a linkage, R6 is a heterocyclic ring, and n is 0, 1 or 2. Said method comprises the production of an intermediate compound of the formula (VI) where R?1, R3, R4 and R5¿ have the meanings given above. This step is followed by halogenation, thiomethylation, oxidation and acylation to yield compounds of formula (I). The invention also relates to new intermediate products for producing compounds of formula (I) and new methods for producing the intermediate products.

公开(公告)号：EP1692115A1

公开(公告)日：2006-08-23

申请号：EP04803387.2

申请日：2004-12-01

Applicant: BASF Aktiengesellschaft

Inventor： HAMPRECHT, Gerhard ,  PUHL, Michael ,  WOLF, Bernd ,  KEIL, Michael ,  REINHARD, Robert ,  SEITZ, Werner ,  MAYER, Guido

IPC: C07D239/56 ,  C07D239/54

CPC classification number: C07D239/54 ,  C07D239/56

Abstract: The invention relates to a method for producing 3-phenyl(thio)uracils or 3-phenyldithiouracils of formula (I), by reacting a phenyliso(thio)cyanate of formula (II) with an enamine of formula (III) and optionally reacting in an additional step the 3-phenyl(thio)uracil or 3-phenyldithiouracil of formula (I) with R1 = R1a, if R1 is hydrogen, with an aminating agent of formula (IV) to give 3-phenyl(thio)uracils or 3-phenyldithiouracils of formula (I) with R1 = amine, wherein the variables R1, R1a, R2, R3, R4, X1, X2, X3, Ar, A and L1 are defined as in claim 1.

公开(公告)号：EP1301469B1

公开(公告)日：2006-06-21

申请号：EP01967194.0

申请日：2001-07-17

Applicant: BASF Aktiengesellschaft

Inventor： LOCHTMAN, Rene ,  KEIL, Michael ,  GEBHARDT, Joachim ,  RACK, Michael ,  VON DEYN, Wolfgang

IPC: C07C251/40 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10

CPC classification number: C07D413/04 ,  C07C319/14 ,  C07D261/04 ,  C07C323/62

Abstract: A process for preparing 4-thioalkylbromobenzene derivatives of the formula I, (I), where: R1 is C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, halogen; R2 is C1-C6-alkyl, C1-C6-alkoxy, C3-C8-cycloalkyl, C2-C6-alkenyl, cyano or a heterocyclic radical; R3 is C1-C6-alkyl, which comprises reacting a compound of the formula II, (II), in which R?1 and R2¿ are as defined above, with a dialkyl disulfide of the formula III, (III), in the presence of a nitrite and a catalyst in a suitable solvent is described.

公开(公告)号：EP1572613A1

公开(公告)日：2005-09-14

申请号：EP03785691.1

申请日：2003-12-01

Applicant: BASF Aktiengesellschaft

Inventor： MAYWALD, Volker ,  HOFFMANN, Nico ,  KEIL, Michael ,  VOGELBACHER, Uwe, Josef ,  WEVERS, Jan, Hendrik

IPC: C07C45/46 ,  C07C45/81 ,  C07C49/84 ,  C07C51/60 ,  C07C51/363

CPC classification number: C07C51/363 ,  C07C45/46 ,  C07C45/81 ,  C07C51/60 ,  C07C49/84 ,  C07C65/21

Abstract: Disclosed is a method for producing benzophenones of formula I, wherein X can represent chlorine, hydroxy, methoxy, or C1-C6 alkylcarbonyloxy while Y represents chlorine or bromine, by reacting an acid chloride of formula II, wherein X and Y have the meaning mentioned above, with 3,4,5-trimethoxytoluene. The inventive method is characterized by the fact that the reaction is carried out in the presence of a) an aromatic hydrocarbon as a thinner, and b) 0.01 to 0.2 mole percent of an iron catalyst, the percentage being in relation to the acid chloride, c) at a temperature ranging between 60oC and the boiling point of the respective thinner.

公开(公告)号：EP0946514B1

公开(公告)日：2003-05-02

申请号：EP97953736.2

申请日：1997-12-04

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： VOGELBACHER, Uwe, Josef ,  KEIL, Michael ,  KLINTZ, Ralf ,  WAHL, Joseph ,  WINGERT, Horst ,  KÖNIG, Hartmann ,  RACK, Michael ,  GÖTZ, Roland ,  TELES, Joaquim, Henrique

IPC: C07D231/20 ,  C07D231/22

CPC classification number: C07D231/22 ,  C07D231/20

Abstract: The invention relates to a method for producing n-substituted 3-hydroxypyrazoles of formula (I), wherein R1 stands for optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heteroaryl and R?2 and R3¿ mean hydrogen, cyano, halogen and optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heteroaryl, by oxidizing a corresponding pyrazolidin-3-ons.

公开(公告)号：EP1265837A2

公开(公告)日：2002-12-18

申请号：EP00977582.6

申请日：2000-11-27

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： GÖTZ, Roland ,  GÖTZ, Norbert ,  KEIL, Michael ,  WOLF, Bernd ,  STEINMETZ, Adrian ,  STAMM, Armin ,  HENKELMANN, Jochem

IPC: C07C51/60 ,  C07C63/10

CPC classification number: C07C51/60 ,  C07C63/10

Abstract: The invention relates to a method for producing o-chloromethyl benzoic acid chlorides of formula (I), in which R1 to R4 can be the same or different and represent hydrogen C¿1?-C4 alkyl, halogen or trifluoromethyl, by reacting benzo-condensed lactones of formula (II), in which R?1 to R4¿ have the above-mentioned meaning, with thionyl chloride. The inventive method is characterized in that the reaction is carried out in the presence of catalytic quantities of a Lewis acid and in the presence of catalytic quantities of a phosphine derivative.

Abstract translation: 本发明涉及制备式（I）的邻氯甲基苯甲酰氯的方法，其中R 1至R 4可以相同或不同并表示氢C 1 -C 4烷基，卤素或三氟甲基， 其中R 1至R 4具有上述含义的式（II）的缩合内酯与亚硫酰氯反应。 本发明的方法的特征在于反应在催化量的路易斯酸存在下和在催化量的膦衍生物存在下进行。