公开(公告)号：WO1995002184A1

公开(公告)日：1995-01-19

申请号：PCT/US1994007549

申请日：1994-07-06

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  DIERENFELDT-TROY, Susan

IPC: G01N33/545

CPC classification number: G01N33/532 ,  G01N33/545

Abstract: Methods and compositions are provided for immunoassays in which a specific binding receptor is coupled to a polymer having a linear backbone. The resulting receptor: polymer complex is soluble in aqueous solution. The complex provides the advantage of performing assays without the use of secondary binding reagents or without the use of particles.

Abstract translation: 提供了用于免疫测定的方法和组合物，其中特异性结合受体与具有线性主链的聚合物偶联。 所得的受体：聚合物复合物可溶于水溶液。 该复合物提供了在不使用二次结合试剂的情况下进行测定或不使用颗粒的优点。

公开(公告)号：WO1995001845A1

公开(公告)日：1995-01-19

申请号：PCT/US1994007550

申请日：1994-07-06

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  HADDAD, Antoine, E. ,  MAZZA, John, C.

IPC: B06B03/00

CPC classification number: B06B3/00

Abstract: A system (5) for ultrasonic energy coupling includes an ultrasonic transducer (11), a horn member (12) defining a passageway (14), and a pump (17) for moving fluid through the passageway and outwardly of the horn. The method used to accomplish the energy coupling or transfer includes vibrating the horn member with an ultrasonic transducer and pumping fluid through the passageway in the horn member and onto an object.

Abstract translation: 一种用于超声波能量耦合的系统（5）包括超声换能器（11），限定通道（14）的喇叭部件（12）和用于使流体通过通道和喇叭外部移动的泵（17）。 用于实现能量耦合或传递的方法包括用超声换能器振动喇叭部件，并将流体通过喇叭部件中的通道泵送到物体上。

公开(公告)号：WO1995001571A1

公开(公告)日：1995-01-12

申请号：PCT/US1994007258

申请日：1994-06-28

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  TANG, ShaMay ,  CARD, Kimberlyn, F. ,  MOTLEY, Leslie ,  WONG, Hing

IPC: G01N33/86

CPC classification number: C07K16/36 ,  G01N33/86 ,  G01N2333/96444

Abstract: A process to prepare factor X deficient plasma is provided. In this process, normal plasma is contacted with an immunoadsorbent having a monoclonal antibody to factor X attached. The factor X binds to the immunoadsorbent and the factor X deficient plasma is collected. The antifactor X antibody immunoadsorbent may be reused. Monoclonal antibodies to factor X are also provided.

Abstract translation: 提供了制备因子X缺乏血浆的方法。 在该过程中，将正常血浆与具有连接的因子X的单克隆抗体的免疫吸附剂接触。 因子X结合免疫吸附剂并收集因子X缺陷血浆。 抗体X抗体免疫吸附剂可以重复使用。 还提供了X因子单克隆抗体。

公开(公告)号：WO1994019693A1

公开(公告)日：1994-09-01

申请号：PCT/US1994001539

申请日：1994-02-09

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  LIN, Spencer, H. ,  YU, Kwok, Sum ,  SINGH, Pratap ,  DIAMOND, Steven, E.

IPC: G01N33/545

CPC classification number: G01N33/54306 ,  G01N33/545 ,  G01N33/552 ,  Y10S436/817 ,  Y10S436/823 ,  Y10S530/811

Abstract: Methods and compositions are provided for specific binding assays in which specific binding reagents are immobilized on a solid phase. Immobilization is facilitated by covalently coupling specific binding assay reagents such as polypeptide receptors or analytes with water soluble polymers. Such water soluble polymers, for example star polymers such as dendrimers, provide production advantages of lot-to-lot uniformity and homogeneity, and can enhance sensitivity due to low non-specific binding to the solid phase.

Abstract translation: 提供了用于特异性结合试验的方法和组合物，其中特异性结合试剂固定在固相上。 通过将特异性结合测定试剂如多肽受体或分析物与水溶性聚合物共价偶联来促进固定化。 这样的水溶性聚合物，例如星形聚合物，例如树枝状聚合物，提供了批次均匀性和均匀性的生产优点，并且由于低固定相的非特异性结合而提高了灵敏度。

公开(公告)号：WO1993015408A1

公开(公告)日：1993-08-05

申请号：PCT/US1993000596

申请日：1993-01-22

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  BACH, David, T. ,  COLE, Randall, J.

IPC: G01N35/02

CPC classification number: G01N35/0092 ,  G01N35/021 ,  G01N35/025 ,  G01N35/1079 ,  G01N2035/0097 ,  G01N2035/0408 ,  G01N2035/0446

Abstract: The present invention relates to an apparatus for randomly detecting blood coagulation in a sample. The apparatus includes a reaction container wheel (2), a sampling station (6), a reaction container transfer means for transferring the reaction containers to a reaction wheel (14), a driving means for continuously indexing the reaction wheel (14), a plurality of reagent addition means positioned along the reaction wheel to allow for a complete incubation, without changing the rate of indexing of the reaction wheel, prior to detection and a plurality of detection means (48) are positioned along the reaction wheel to detect the rate of reaction without changing the rate of indexing of the reaction wheel. The apparatus is used to detect blood coagulation in a sample.

Abstract translation: 本发明涉及一种随机检测样品中血液凝固的装置。 该装置包括反应容器轮（2），采样站（6），用于将反应容器传送到反作用轮（14）的反应容器传送装置，用于使反作用轮（14）连续分度的驱动装置， 多个试剂添加装置沿着反应轮定位，以允许在检测之前不改变反作用轮的分度速率的完全孵育，并且沿反应轮定位多个检测装置（48）以检测速率 的反应，而不改变反作用轮的分度率。 该装置用于检测样品中的血液凝固。

公开(公告)号：WO1993013400A2

公开(公告)日：1993-07-08

申请号：PCT/US1992011132

申请日：1992-12-18

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  KAUL, Jeffery, W. ,  RAYMO, Joseph, D. ,  HENRY, Michael, R.

IPC: G01N0

CPC classification number: G01N35/1004 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1065 ,  G01N2035/0422 ,  G01N2035/0425 ,  G01N2035/0484

Abstract: Washing/aspiration systems and associated methods for assays employing paramagnetic solid phase binding particles (422) remove fluid and unbound components from the test well (18) without losing the paramagnetic particles (422) in the process. In one arrangement, the surface tension of the fluid in the well (18) is altered in a preselected manner to redistribute larger volumes of fluid away from the center region of the well (18) and toward the side region of the well (18). Fluid is aspirated from the side region, freeing the center region of the well (18) for the collection and concentration of the paramagnetic particles (422) away from the aspiration flow. In another arrangement, the distribution of the paramagnetic particles (422) in the well (18) is altered by subjecting the particles to a dynamic magnetic field (602; 608) that varies the direction and intensity of the magnetic gradient as a function of time. The dynamic magnetic field (602; 608) collects and concentrates the particles (422) within a region of the test well (18) away from the aspiration probe.

Abstract translation: 清洗/抽吸系统和使用顺磁性固相结合颗粒（422）的测定法的相关方法从测试孔（18）中除去流体和未结合的组分，而不会损失该过程中的顺磁性颗粒（422）。 在一种布置中，井（18）中的流体的表面张力以预先选择的方式改变，以将更大体积的流体重新分布远离井（18）的中心区域并且朝向井（18）的侧部区域， 。 从侧面区域吸出流体，释放孔（18）的中心区域，以将顺磁性颗粒（422）收集和浓缩远离抽吸流。 在另一种布置中，顺磁粒子（422）在孔（18）中的分布通过使颗粒经受改变磁梯度的方向和强度作为时间的函数的动态磁场（602; 608）来改变 。 动态磁场（602; 608）将测试井（18）的区域内的颗粒（422）收集并浓缩远离抽吸探针。

公开(公告)号：WO1993009596A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009082

申请日：1992-10-27

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  GARAND, Steven, A. ,  DANIEL, Carl, P.

IPC: H02P08/00

CPC classification number: G01N35/1002 ,  G01N35/025 ,  G01N35/028 ,  G01N2021/1759 ,  G01N2035/00079 ,  G01N2035/00455 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0463 ,  G01N2035/0475 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283

Abstract: An improved control system for a stepper motor coil (190) includes a flyback circuit (192) that dissipates coil energy slowly while the coil is energized and operated in the chopping mode, while dissipating coil energy rapidly when the coil is switched to its de-energized phase.

Abstract translation: 用于步进电动机线圈（190）的改进的控制系统包括反激电路（192），其在线圈被通电并且以斩波模式操作时缓慢地消散线圈能量，同时当线圈切换到其去耦时消散线圈能量， 通电阶段。

公开(公告)号：WO1993009441A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009098

申请日：1992-10-27

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  MASTERSON, Brian, K. ,  CAMPBELL, Randolph, L. ,  DANIEL, Craig, M.

IPC: G01N35/06

CPC classification number: G01N35/1002 ,  G01N35/028 ,  G01N2035/0425 ,  Y10S435/809 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/2575

Abstract: A system (10) for processing a specimen to which fluid must be added includes a fluid dispensing work station (16) within a housing. The work station (16) holds the fluids that are to be added to the specimen. A nozzle (148) dispenses fluid at the work station. The system (10) also includes a carrier (24) that moves within the housing. The carrier (24) operates in a first mode at the fluid dispensing work station (16). The carrier also operates in a second mode outside the work station (16) to perform a different processing function. A coupling mechanism (170) attaches the nozzle (148) to the carrier (24) when the carrier (24) enters its first operational mode to transport the nozzle (148) around the fluid dispensing station (16). The coupling mechanism (170) releases the nozzle (148) from the carrier (24) when the carrier (24) enters its second operational mode, thereby freeing the carrier (24) for movement outside the work station (16) out of association with the nozzle (148).

Abstract translation: 用于处理必须加入流体的试样的系统（10）包括在壳体内的流体分配工作站（16）。 工作站（16）保持要添加到样品中的流体。 喷嘴（148）在工作站处分配流体。 系统（10）还包括在壳体内移动的托架（24）。 载体（24）在流体分配工作站（16）处以第一模式操作。 载体还以工作站（16）外的第二模式操作，以执行不同的处理功能。 当载体（24）进入其第一操作模式时，联接机构（170）将喷嘴（148）附接到载体（24），以将喷嘴（148）输送到流体分配站（16）周围。 当载体（24）进入其第二操作模式时，联接机构（170）从载体（24）释放喷嘴（148），从而释放载体（24）在工作站（16）外运动，与 喷嘴（148）。

公开(公告)号：WO1993009440A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009097

申请日：1992-10-27

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  GRINER, Christopher, D.

IPC: G01N35/02

CPC classification number: G01N21/253 ,  G01N21/274 ,  G01N35/028 ,  G01N2201/0407 ,  G01N2201/0446 ,  G01N2201/08 ,  G01N2201/1283

Abstract: A system (10) uses a photometer that establishes an optical channel between a light emitter (102) and a light detector (106). The photometer analyzes a specimen while it occupies a well (48) in a tray (12). A movable platform (74) transports the tray (12) to the optical channel for analysis and removes the tray (12) from the optical channel after analysis. The system calibrates the movable platform (74) to assure proper alignment between the specimen and the photometric apparatus used to analyze the specimen. The system also calibrates the optical channel without use of an external reference.

Abstract translation: 系统（10）使用在光发射器（102）和光检测器（106）之间建立光通道的光度计。 光度计在托盘（12）中占据井（48）时对样本进行分析。 可移动平台（74）将托盘（12）运送到光学通道用于分析，并在分析之后从光学通道中移除托盘（12）。 系统校准可移动平台（74），以确保样品与用于分析样品的测光设备之间的正确对准。 该系统还可以校准光通道而不使用外部参考。

公开(公告)号：WO1993009252A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009376

申请日：1992-11-04

Applicant: BAXTER DIAGNOSTICS INC.

Inventor： BAXTER DIAGNOSTICS INC. ,  SHAH, Dinesh, O. ,  SCHNEIDER, Andrew

IPC: C12Q01/70

CPC classification number: C07K14/005 ,  C12N2740/16122 ,  G01N33/56988

Abstract: The present invention relates to synthetic peptides of HIV-2 and method to use the synthetic peptides in an improved immunoassay for antibodies to HIV-2. The antigenic peptide of formula (Sequece Id. No. 1 or 2), the improvement involving adding Lysine substantially adjacent to the N or C terminus of the peptide and adding a glycine between Lysine and Aspartic acid if Lysine is added to the N-terminus of the antigenic peptide.

Abstract translation: 本发明涉及HIV-2的合成肽以及在HIV-2抗体的改进免疫测定中使用合成肽的方法。 式（Sequece Id。No.1或2）的抗原肽，涉及将赖氨酸与肽的N或C末端基本相邻并在赖氨酸和天冬氨酸之间加入甘氨酸的改进，如果将赖氨酸加入到N-末端 的抗原肽。