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    STABLE PHARMACEUTICAL FORMULATIONS
    21.
    发明专利
    STABLE PHARMACEUTICAL FORMULATIONS 未知

    公开(公告)号：CA2722602A1

    公开(公告)日：2009-11-19

    申请号：CA2722602

    申请日：2009-05-08

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： KIPP JAMES E ,  WONG JOSEPH C T ,  NAIR LAKSHMY ,  MILLER REAGAN ,  RABINOW BARRETT E

    IPC: A61K9/00 ,  A61K47/10 ,  A61K47/40

    Abstract: Stable pharmaceutical formulations and methods of making same are provided. In a general embodiment, the present disclosure provides a method of making a stable pharmaceutical formulation comprising adding one or more vitrifying additives to an aqueous pharmaceutical solution to raise the glass transition temperature of the aqueous pharmaceutical solution. The aqueous pharmaceutical solution can be cooled to a temperature of about -50 C to about -10 C. The vitrifying additive enhances the formation of a glass or amorphous solid of the aqueous pharmaceutical solution at cryogenic temperatures (-50 to -10C), and the pharmaceutical formulation can be thawed to liquid form and administered to a mammalian subject.

    Compositions comprising lipoxygenase inhibitors and cyclodextrin
    22.
    发明专利
    Compositions comprising lipoxygenase inhibitors and cyclodextrin 未知

    公开(公告)号：ZA200805087B

    公开(公告)日：2009-06-24

    申请号：ZA200805087

    申请日：2008-06-11

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： KIPP JAMES E ,  PRAMOD GUPTA

    IPC: A61K20090101 ,  A61P20090101

    Abstract: The present invention is directed to formulations of inclusion complexes of lipoxygenase inhibitors and cyclodextrins having a therapeutically effective concentration of the lipoxygenase inhibitor, methods of making the same and methods of treating disease states using the same. Forming cyclodextrin complexes permits the enhancement of the aqueous solubility of lipoxygenase inhibitors which allows higher concentrations of the lipoxygenase in solution. Aqueous formulations of lipoxygenase inhibitors-cyclodextrin complexes are suitable for parenteral or oral administration for treating and/or preventing inflammatory disease states. The aqueous formulations can be lyophilized to prolong storage stability, assist in oral administration and/or provide for convenient and economical packaging.

    PROCEDIMIENTO PARA PREPARAR SUSPENSIONES DE PARTICULAS SUBMICRONICAS DE AGENTES FARMACEUTICOS.
    26.
    发明专利
    PROCEDIMIENTO PARA PREPARAR SUSPENSIONES DE PARTICULAS SUBMICRONICAS DE AGENTES FARMACEUTICOS. 未知

    公开(公告)号：ES2260337T3

    公开(公告)日：2006-11-01

    申请号：ES01998077

    申请日：2001-12-20

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE

    IPC: C07D407/14 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P31/10 ,  A61K9/20 ,  A61K9/51 ,  A61K31/192 ,  A61K31/55 ,  A61K31/573

    Abstract: Método para preparar partículas de tamaño submicrométrico de un compuesto farmacéuticamente activo cuya solubilidad es mayor en un primer disolvente miscible en agua que en un segundo disolvente que es acuoso, comprendiendo el proceso las etapas de: (i) disolver el compuesto farmacéuticamente activo en el primer disolvente miscible en agua para formar una solución, seleccionándose el primer disolvente de entre el grupo formado por N-metil-2-pirrolidinona, 2- pirrolidona, sulfóxido de dimetilo, dimetilacetamida, ácido láctico, metanol, etanol, isopropanol, 3- pentanol, n-propanol, glicerina, butilenglicol, etilenglicol, propilenglicol, monoglicéridos mono- y di-acilados, isosorbido de dimetilo, acetona, dimetilformamida, 1, 4-dioxano, acetato de etilo, acetato de propilo, polietilenglicol, polietilenglicol ésteres, sorbitanos de polietilenglicol, monoalquil polietilenglicol éteres, polipropilenglicol, alginato de polipropileno, propilenglicol 10 butanodiol, propilenglicol 10 metilglucosa éter, propilenglicol 20 metilglucosa éter, propilenglicol 15 estearil éter, dicaprilato de propilenglicol, dicaprato de propilenglicol, laurato de propilenglicol; (ii) mezclar la solución con el segundo disolvente para definir una presuspensión; y (iii) añadir energía a la presuspensión para formar partículas que tengan un tamaño de partícula medio efectivo inferior a aproximadamente 2 ìm, y dicha etapa de adición de energía comprende homogeneización, homogeneización por flujo a contracorriente, microfluidización o sonicación.

    28.
    发明专利
    未知

    公开(公告)号：BRPI0408517A

    公开(公告)日：2006-03-07

    申请号：BRPI0408517

    申请日：2004-02-25

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  WERLING JANE ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN

    IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

    Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 mum. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.

    Ex-vivo application of solid microparticulate therapeutic agents
    29.
    发明专利
    Ex-vivo application of solid microparticulate therapeutic agents 未知

    公开(公告)号：AU2005255039A1

    公开(公告)日：2005-12-29

    申请号：AU2005255039

    申请日：2005-06-08

    Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

    Inventor： KIPP JAMES E ,  RABINOW BARRETT E

    IPC: C12N5/06 ,  A61K9/14 ,  A61K35/12 ,  A61K45/00 ,  A61K47/48 ,  A61K49/00

    Abstract: The present invention is concerned with a method of preparing and delivering small particles of a pharmaceutically active material to a mammalian subject for treating diseases or disorders. A preferred embodiment entails: (i) the collection of tissue cells from an animal donor, (ii) selective or non-selective growth of these cells in a cell culture medium to which is added solid particles of a therapeutically active compound, mostly free of a drug carrier (about 10% or less, by weight), and having an average particle size of less than about 100 microns, (iii) contacting the cells in the cell culture medium with the solid particles of therapeutically active compound causing the particles to be taken up by the cells into either the intracellular compartment of the cultured cells, attachment of the active compound as particles to the periphery of such cells, or a combination of intracellular uptake and attachment to the cell surface, (iv) optionally, isolation and/or resuspension of the cells prepared in steps i through iii, (v) administering the cells to the mammalian subject. The pharmaceutically active material can be administered intravenously, intramuscularly, subcutaneously, intradermally, intra-articularly, intrathecally, epidurally, intracerebrally, via buccal route, rectally, topically, transdermally, orally, intranasally, via pulmonary route, intraperitoneally, or combinations thereof. After administration, the loaded cells transport the pharmaceutical composition as particles.

    30.
    发明专利
    未知

    公开(公告)号：NO20054732L

    公开(公告)日：2005-10-14

    申请号：NO20054732

    申请日：2005-10-14

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE

    IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/12 ,  A61K31/337 ,  A61K31/495 ,  A61K31/496 ,  A61K31/55 ,  A61K31/573

    Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 mum. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.

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