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1.发明申请SOLID PARTICLES COMPRISING AN ANTICONVULSANT OR AN IMMUNOSUPPRESSIVE COATED WITH ONE OR MORE SURFACE MODIFIERS 审中-公开包含抗微生物剂或用一种或多种表面改性剂涂覆的免疫抑制剂的固体颗粒
公开(公告)号：WO2004103348A3
公开(公告)日：2005-01-06
申请号：PCT/US2004015621
申请日：2004-05-19
Applicant: BAXTER INT , BARRETT RABINOW E , WERLING JANE , KONKEL JAMIE TERESA , DOTY MARK J , REBBECK CHRISTINE L
Inventor： BARRETT RABINOW E , WERLING JANE , KONKEL JAMIE TERESA , DOTY MARK J , REBBECK CHRISTINE L
Abstract: This invention pertains to the formulation of small-particle suspensions of anticonvulsants, particularly carbamazepine, for pharmaceutical use. This invention also pertains to the formulation of a small-particle suspensions of immunosuppressive agents, particularly cyclosporin, for pharmaceutical use. The particles are coated with one or more surface modifiers.
Abstract translation: 本发明涉及用于药物用途的抗惊厥药，特别是卡马西平的小颗粒悬浮液的制剂。 本发明还涉及用于药物用途的免疫抑制剂，特别是环孢菌素的小颗粒悬浮液的制剂。 颗粒被一个或多个表面改性剂涂覆。
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公开(公告)号：DK1435909T3
公开(公告)日：2010-03-15
申请号：DK02773797
申请日：2002-10-18
Applicant: BAXTER INT
Inventor： KONKEL JAMIE TERESA , KIPP JAMES E , DOTY MARK J , REBBECK CHRISTINE L , BRYNJELSEN SEAN
IPC: A61K9/10 , A61K8/02 , A61K8/04 , A61K8/06 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/64 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K9/107 , A61K9/14 , A61K31/12 , A61K31/4985 , A61K31/58 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61K47/46 , A61Q19/00
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公开(公告)号：AU2002337894B2
公开(公告)日：2007-07-12
申请号：AU2002337894
申请日：2002-10-18
Applicant: BAXTER INT
Inventor： KONKEL JAMIE TERESA , DOTY MARK J , BRYNJELSEN SEAN , REBBECK CHRISTINE L , KIPP JAMES E
IPC: A61K9/10 , A61K8/02 , A61K8/04 , A61K8/06 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/64 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K9/107 , A61K9/14 , A61K31/12 , A61K31/4985 , A61K31/58 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61K47/46 , A61Q19/00
Abstract: The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.
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公开(公告)号：AU2004240640A1
公开(公告)日：2004-12-02
申请号：AU2004240640
申请日：2004-05-19
Applicant: BAXTER INT
Inventor： DOTY MARK J , KONKEL JAMIE TERESA , REBBECK CHRISTINE L , WERLING JANE , BARRETT RABINOW E
Abstract: This invention pertains to the formulation of small-particle suspensions of anticonvulsants and antidementia, particularly carbamazepine, for pharmaceutical use. This invention also pertains to the formulation of small-particle suspensions of immunosuppressive agents, particularly cyclosporin, for pharmaceutical use.
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公开(公告)号：CA2463313A1
公开(公告)日：2003-05-01
申请号：CA2463313
申请日：2002-10-18
Applicant: BAXTER INT
Inventor： DOTY MARK J , KONKEL JAMIE TERESA , REBBECK CHRISTINE L , BRYNJELSEN SEAN , KIPP JAMES E
IPC: A61K8/02 , A61K8/04 , A61K8/06 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/64 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K9/10 , A61K9/107 , A61K9/14 , A61K31/12 , A61K31/4985 , A61K31/58 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61K47/46 , A61Q19/00
Abstract: The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particl es of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.
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Patent Agency Ranking
公开(公告)号：ES2340261T3
公开(公告)日：2010-06-01
申请号：ES02773797
申请日：2002-10-18
Applicant: BAXTER INT
Inventor： KIPP JAMES E , DOTY MARK J , REBBECK CHRISTINE L , BRYNJELSEN SEAN , KONKEL JAMIE TERESA
IPC: A61K9/10 , A61K8/02 , A61K8/04 , A61K8/06 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/64 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K9/107 , A61K9/14 , A61K31/12 , A61K31/4985 , A61K31/58 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61K47/46 , A61Q19/00
Abstract: Composición de una suspensión de un agente farmacéutico orgánico poco soluble en agua que comprende partículas del compuesto y un excipiente en una cantidad del 0,001% al 20% con respecto al peso total de la composición suspendida en una matriz acuosa congelada, caracterizada porque el excipiente incluye dos o más modificadores superficiales seleccionados de entre agentes tensioactivos aniónicos, agentes tensioactivos catiónicos, agentes tensioactivos no iónicos y modificadores biológicos activos superficiales, donde los modificadores biológicos activos superficiales se seleccionan de entre el grupo consistente en albúmina, caseína, heparina, hirudina u otras proteínas, y caracterizada porque más del 99% aproximadamente de las partículas tiene un tamaño de partícula inferior a 5 micras.
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公开(公告)号：NO20056020A
公开(公告)日：2005-12-16
申请号：NO20056020
申请日：2005-12-16
Applicant: BAXTER INT
Inventor： DOTY MARK J , REBBECK CHRISTINE L , WERLING JANE , BARRETT RABINOW E , KONKEL JAMIE TERESA
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公开(公告)号：CA2524538A1
公开(公告)日：2004-12-02
申请号：CA2524538
申请日：2004-05-19
Applicant: BAXTER INT
Inventor： BARRETT RABINOW E , WERLING JANE , DOTY MARK J , REBBECK CHRISTINE L , KONKEL JAMIE TERESA
Abstract: This invention pertains to the formulation of small-particle suspensions of anticonvulsants, particularly carbamazepine, for pharmaceutical use. This invention also pertains to the formulation of a small-particle suspensions o f immunosuppressive agents, particularly cyclosporin, for pharmaceutical use. The particles are coated with one or more surface modifiers.
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公开(公告)号：DE60234618D1
公开(公告)日：2010-01-14
申请号：DE60234618
申请日：2002-10-18
Applicant: BAXTER INT
Inventor： KIPP JAMES E , DOTY MARK J , REBBECK CHRISTINE L , BRYNJELSEN SEAN , KONKEL JAMIE TERESA
IPC: A61K9/10 , A61K8/02 , A61K8/04 , A61K8/06 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/64 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K9/107 , A61K9/14 , A61K31/12 , A61K31/4985 , A61K31/58 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61K47/46 , A61Q19/00
Abstract: The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.
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公开(公告)号：BRPI0410767A
公开(公告)日：2006-07-04
申请号：BRPI0410767
申请日：2004-05-19
Applicant: BAXTER INT
Inventor： BARRETT RABINOW E , WERLING JANE , KONKEL JAMIE TERESA , DOTY MARK J , REBBECK CHRISTINE L
Abstract: This invention pertains to the formulation of small-particle suspensions of anticonvulsants and antidementia, particularly carbamazepine, for pharmaceutical use. This invention also pertains to the formulation of small-particle suspensions of immunosuppressive agents, particularly cyclosporin, for pharmaceutical use.
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