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    DISPERSIONS PREPARED BY USE OF SELF-STABILIZING AGENTS
    2.
    发明申请
    DISPERSIONS PREPARED BY USE OF SELF-STABILIZING AGENTS 审中-公开
    使用自稳定剂制备的分散体

    公开(公告)号：WO2005077337A3

    公开(公告)日：2006-03-23

    申请号：PCT/US2005002471

    申请日：2005-01-26

    Applicant: BAXTER INT ,  KIPP JAMES E ,  DOTY MARK ,  REBBECK CHRISTINE L

    Inventor： KIPP JAMES E ,  DOTY MARK ,  REBBECK CHRISTINE L

    IPC: A61K9/113 ,  A61K9/107 ,  A61K9/127 ,  A61K31/557 ,  A61K38/17 ,  A61K48/00

    CPC classification number: A61K9/1075 ,  A61K9/113 ,  A61K31/557

    Abstract: The present invention relates to a dispersion of an active agent, which includes a multiphase system of an organic phase and an aqueous phase. The agent, preferably poorly water soluble, possesses surface active properties and itself serves as a dispersantor a stabilizer for the dispersion. The dispersion is suitable for pharmaceutical, veterinary, cosmetic, and agricultural applications, and is suitable for in vivo delivery, particularly by parenteral routes.

    Abstract translation: 本发明涉及活性剂的分散体，其包括有机相和水相的多相体系。 优选水溶性差的试剂具有表面活性，并且其本身用作分散剂或分散体的稳定剂。 该分散体适用于药物，兽医，化妆品和农业应用，并且适合于体内递送，特别是通过肠胃外途径。

    A REFERENCE ELECTRODE SOLUTION CONTAINING ORGANIC AMMONIUM AND PHOSPHONIUM SALTS FOR POTENTIOMETRIC MEASUREMENT OF pH
    3.
    发明申请
    A REFERENCE ELECTRODE SOLUTION CONTAINING ORGANIC AMMONIUM AND PHOSPHONIUM SALTS FOR POTENTIOMETRIC MEASUREMENT OF pH 审中-公开
    包含有机氨和磷酸盐的参考电极溶液用于电位测量pH

    公开(公告)号：WO0033064A9

    公开(公告)日：2001-03-29

    申请号：PCT/US9928567

    申请日：1999-12-02

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WEHRMANN GLENN JR ,  HAMMOND RICHARD B ,  REBBECK CHRISTINE L

    IPC: G01N27/30 ,  G01N27/416

    CPC classification number: G01N27/301

    Abstract: The present invention provides a reference electrode solution containing ammonium salts and phosphonium salts for the potentiometric measurement of pH and method of using the same. The use of the ammonium salts and the phosphonium salts to replace potassium chloride or sodium chloride as reference electrolytes in a standard reference electrode minimizes the formation of precipitates in sample solutions containing cation-sensitive compounds. Disruption of ion flow through the reference electrode is eliminated, and accurate pH measurements may be obtained in solutions that contain compounds having a strong affinity for hard cations.

    Abstract translation: 本发明提供了含有铵盐和鏻盐的参比电极溶液，用于电位测量pH值和使用该方法。 在标准参考电极中使用铵盐和鏻盐代替氯化钾或氯化钠作为参考电解质，使含有阳离子敏感化合物的样品溶液中沉淀物的形成最小化。 消除通过参比电极的离子流的破坏，并且可以在含有对硬阳离子具有强亲和力的化合物的溶液中获得精确的pH测量。

    PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE
    5.
    发明申请
    PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE 审中-公开
    具有聚合物控制和新戊酰胺的新型聚合物的亚型尺寸颗粒的制备

    公开(公告)号：WO2004054500A3

    公开(公告)日：2004-08-26

    申请号：PCT/US0324353

    申请日：2003-08-04

    Applicant: BAXTER INT

    Inventor： WERLING JANE ,  KIPP JAMES E ,  SRIRAM RAJARAM ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  WONG JOSEPH CHUNG TAK

    IPC: A61K9/00 ,  A61K31/495 ,  A61K9/127 ,  A61K9/14

    CPC classification number: A61K9/14 ,  A61K9/0019 ,  A61K9/10 ,  A61K31/495

    Abstract: The present invention provides a method of preparing particles with polymorph and size control of a pharmaceutical compound, the method including the steps of: (1) providing pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particle size of the particles is less than 7µm. The present invention further provides a polymorphic form of itraconazole.

    Abstract translation: 本发明提供一种制备具有药物化合物的多晶型物和粒度控制的颗粒的方法，所述方法包括以下步骤：（1）在第一相中提供药物化合物; （2）接种化合物; （3）引起药物化合物相变为所需多晶型物的第二相; 和（4）其中颗粒的平均粒度小于7μm。 本发明还提供了伊曲康唑的多晶型物。

    PREMIXED AMIODARONE PARENTERAL SOLUTION AND METHOD FOR MAKING THE SAME
    6.
    发明申请
    PREMIXED AMIODARONE PARENTERAL SOLUTION AND METHOD FOR MAKING THE SAME 审中-公开
    预先使用的AMIODARONE公司解决方案及其制备方法

    公开(公告)号：WO02078605A3

    公开(公告)日：2003-02-06

    申请号：PCT/US0210094

    申请日：2002-03-28

    Applicant: BAXTER INT

    Inventor： DOTY MARK J ,  REBBECK CHRISTINE L ,  KIPP JAMES E ,  RAGHAVAN NEERVALUR V

    IPC: C07D307/80 ,  A61K9/00 ,  A61K9/08 ,  A61K31/343 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61P9/06

    CPC classification number: A61K9/0019 ,  A61K31/343 ,  A61K47/26

    Abstract: A premix parenteral solution for intravenous administration having amiodarone, as an active ingredient, solubilized in a solution of water for injection and about 0.4 - 12 mg/ml of a non-ionic surfactant to a concentration range of from 0.2 to 6 mg/ml is disclosed. The solution optionally may include an osmotic agent. No dilution of the solution is required before administering to a patient and the sterile packaged solution has an initial pH within the range of from about 2.9 to about 3.2, preferably about 3.1. Additionally, a method for producing an amiodarone solution suitable for intravenous administration is further disclosed.

    Abstract translation: 用于静脉内给药的预混合肠胃外溶液，其具有溶解于注射用水和约0.4-12mg / ml非离子表面活性剂的胺碘酮作为活性成分，浓度范围为0.2至6mg / ml， 披露。 溶液任选地可以包括渗透剂。 在给予患者之前不需要稀释溶液，无菌包装溶液的初始pH范围为约2.9至约3.2，优选约3.1。 此外，还公开了适用于静脉内给药的胺碘酮溶液的制备方法。

    Method for preparing submicron particle suspensions
    9.
    发明专利
    Method for preparing submicron particle suspensions 未知

    公开(公告)号：NZ526608A

    公开(公告)日：2006-06-30

    申请号：NZ52660801

    申请日：2001-12-20

    Applicant: BAXTER INT

    Inventor： KIPP JAMES E ,  WONG JOSEPH CHUNG TAK ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  WERLING JANE ,  SRIRAM RAJARAM

    IPC: C07D407/14 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K31/495 ,  A61K31/496 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P31/10 ,  A61K9/20 ,  A61K9/51

    Abstract: A method for preparing submicron sized particles of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous is disclosed, wherein the process comprises the steps of: (i) dissolving the pharmaceutically-active compound in the water-miscible first solvent to form a solution, the first solvent being selected from the group consisting of N methyl-2-pyrrolidinone, 2-pyrrolidone, dimethyl sulfoxide, dimethylacetamide, lactic acid, methanol, ethanol, isopropanol, 3-pentanol, n-propanol, glycerol, butylene glycol, ethylene glycol, polypropylene glycol, mono- and diacylated monoglycerides, dimethyl isosorbide, acetone, dimethylformamide, 1,4-dioxane, ethyl acetate, propyl acetate, polyethylene glycol, polyethylene glycol esters, polyethylene glycol sorbitans, polyethylene glycol monoalkyl ethers, polypolypropylene glycol, polypropylene alginate, polypolypropylene glycol-10 butanediol, polypolypropylene glycol-10 methyl glucose ether, polypolypropylene glycol-20 methyl glucose ether, polypolypropylene glycol-15 stearyl ether, polypolypropylene glycol dicaprylate, polypropylene glycol dicaprate, polypropylene glycol laurate; (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of less than about 2 micron, and said adding energy step comprises homogenization, counter-current flow homogenization, microfluidization or sonication.

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