公开(公告)号：EP1263481A1

公开(公告)日：2002-12-11

申请号：EP01912673.9

申请日：2001-01-26

Applicant: BAXTER INTERNATIONAL INC.

Inventor： WOO, Lecon ,  BOGGS, Daniel, R. ,  STERNBERG, Shmuel ,  SANDFORD, Craig ,  KHARE, Atul ,  BREILLATT, Julian

IPC: A61L2/10 ,  A61L2/02 ,  A61M1/36

CPC classification number: A61M1/3681 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/0281 ,  A61M2202/0415 ,  A61M2205/053

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a 'carrying' mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

公开(公告)号：EP0877648A1

公开(公告)日：1998-11-18

申请号：EP97944406.0

申请日：1997-09-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： PRINCE, Paul, R. ,  PEKKARINEN, Michael, O. ,  BELLAMY, David, Jr. ,  STERNBERG, Shmuel

IPC: B01D39 ,  B01D61 ,  B01D63 ,  B01D65 ,  B01D69 ,  A61M1

CPC classification number: B01D65/08 ,  A61M1/262 ,  A61M1/265 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/3334 ,  B01D39/1692 ,  B01D61/147 ,  B01D61/22 ,  B01D63/16 ,  B01D69/02 ,  B01D2321/20 ,  B01D2321/2025 ,  B01D2321/2058 ,  B01D2321/2066 ,  A61M2202/0042 ,  A61M2202/0035

Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles (104) and (108) which are differently sized or shaped and in which a first type of red cell particle (104) may be deformable at a relatively lower force and/or faster rate than a second type of white cell particle (108). A filter membrane (100) is provided having pores (102) with substantially precisely dimensioned pore sizes, with the pores (102) being dimensioned to allow passage of the first type of particle (104) without distortion or only minimal distortion and passage of the second type of particle (108) only with substantial distortion. Because the filter membrane (100) has precisely dimensioned pores (102), with spacing between the pores (102) being maintained despite the smaller interval between the pores (102), the porosity of the membrane (100) may be relatively much greater, allowing faster filtration rates while reducing shear exposure time and consequently reducing particle damage. Various methods for preventing clogging of the membrane (100) are also disclosed.

公开(公告)号：EP0684866A1

公开(公告)日：1995-12-06

申请号：EP95906088.0

申请日：1994-12-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： STERNBERG, Shmuel ,  LYNN, Daniel, R.

IPC: A61M1 ,  A61K35 ,  B01D29 ,  B01D35 ,  B01D39

CPC classification number: B01D39/2017 ,  A61M1/0222 ,  A61M1/3636 ,  A61M1/3652 ,  A61M2202/0439 ,  B01D29/012 ,  B01D29/58 ,  B01D29/908 ,  B01D39/083 ,  B01D39/1623 ,  B01D39/18 ,  B01D2239/0471 ,  B01D2239/0618 ,  B01D2239/065 ,  B01D2239/0654 ,  B01D2239/1233 ,  Y10S264/26 ,  Y10S264/48 ,  A61M2202/0057

Abstract: A method correlates average fiber diameter with performance for a complex filtration media comprising a matrix of fibers having a fibrillated component with a diameter so small (e.g., less than 0.01 microns), that cannot be physically measured with accuracy. The method manufactures a selected matrix, derives the number average diameter of the fibers according to prescribed steps, some of which do not require actual physical measurements, and observes a performance characteristic. The method repeats the foregoing steps for different matrixes, yielding different number average diameters. The method expresses change in the selected performance characteristic as a function of change in number average diameter of the matrices.

公开(公告)号：EP2658591A2

公开(公告)日：2013-11-06

申请号：EP11811627.6

申请日：2011-12-28

Applicant: Baxter International Inc ,  Baxter Healthcare S.A.

Inventor： DUDAR, Thomas ,  KROGH, Ross ,  MARTUCCI, James ,  STERNBERG, Shmuel

IPC: A61M5/36 ,  A61M5/38

CPC classification number: A61M5/172 ,  A61M5/36 ,  A61M5/365 ,  A61M5/38 ,  A61M5/385 ,  A61M2205/60

Abstract: An intravenous ("IV") liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).

公开(公告)号：EP2367584A1

公开(公告)日：2011-09-28

申请号：EP09792320.5

申请日：2009-09-08

Applicant: Baxter International Inc. ,  Baxter Healthcare S.A.

Inventor： STERNBERG, Shmuel ,  DESAI, Siddharth, B. ,  BLACK, Larry ,  PAULEY, Robin, G.

IPC: A61M5/38 ,  A61M39/20

CPC classification number: G01D7/005 ,  A61M5/141 ,  A61M5/3146 ,  A61M5/385 ,  A61M39/10 ,  A61M39/20 ,  A61M2005/1402 ,  A61M2005/3125 ,  A61M2039/205 ,  A61M2205/331 ,  A61M2205/7536

Abstract: A priming indicator for a fluid infusion system includes a luer cap (20) or other component of the infusion system having an indicator surface (22) covered by a membrane (24). The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.

公开(公告)号：EP2231313A1

公开(公告)日：2010-09-29

申请号：EP08854177.6

申请日：2008-10-06

Applicant: Baxter International Inc. ,  Baxter Healthcare SA

Inventor： STERNBERG, Shmuel

IPC: B01D63/02 ,  B01D69/06 ,  B01D69/08 ,  B01D67/00 ,  A61M1/16

CPC classification number: B01D69/02 ,  A61M1/16 ,  B01D67/0083 ,  B01D67/0088 ,  B01D69/06 ,  B01D69/08 ,  B01D2323/08 ,  B01D2323/283 ,  B01D2325/02 ,  Y10T428/1376 ,  Y10T428/24802 ,  Y10T428/24942

Abstract: Membranes are made from polymers and heat treated so that they have at least two zones with pores of different sizes. Pores with a smaller size have a lower molecular weight cut off than pores with a larger size. Zones with pores of different sizes may also be made by coating portions of membranes with polymer coatings. Membranes with pores of different sizes may be used in dialyzers for hemofiltration, hemodiafiltration, and other hemodialysis procedures. The membranes may also be used in other separation processes.

公开(公告)号：EP1263481B1

公开(公告)日：2010-03-10

申请号：EP01912673.9

申请日：2001-01-26

Applicant: Baxter International Inc.

Inventor： WOO, Lecon ,  BOGGS, Daniel, R. ,  STERNBERG, Shmuel ,  SANDFORD, Craig ,  KHARE, Atul ,  BREILLATT, Julian

IPC: A61L2/10 ,  A61L2/02 ,  A61M1/36

CPC classification number: A61M1/3681 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/0281 ,  A61M2202/0415 ,  A61M2205/053

公开(公告)号：EP1263480B1

公开(公告)日：2010-01-06

申请号：EP01905092.1

申请日：2001-01-26

Applicant: Baxter International Inc.

Inventor： WOO, Lecon ,  BOGGS, Daniel, R. ,  STERNBERG, Shmuel ,  SANDFORD, Craig ,  KHARE, Atul ,  BREILLATT, Julian

IPC: A61L2/10 ,  A61L2/02 ,  A61M1/36

CPC classification number: A61L2/10 ,  A61L2/0011 ,  A61M1/0281 ,  A61M1/3681 ,  A61M2202/0415 ,  A61M2205/053

公开(公告)号：EP1429749A2

公开(公告)日：2004-06-23

申请号：EP02773579.4

申请日：2002-09-25

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BRYNJELSEN, Sean ,  STERNBERG, Shmuel ,  DUNHAM, Andrew, J. ,  DOTY, Mark, J. ,  KIPP, James, E. ,  JAYSWAL, Nailesh ,  NARAYANAN, Krishnaswamy

IPC: A61K9/51

CPC classification number: A61K9/14 ,  A61K9/145 ,  A61K9/5169 ,  A61K9/5192 ,  B01J13/04

Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by sonicating to evaporate a portion of the organic phase or by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase havingthe poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.

公开(公告)号：EP1343571A1

公开(公告)日：2003-09-17

申请号：EP01952845.4

申请日：2001-07-18

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BREILLATT, Julian, P., Jr. ,  STERNBERG, Shmuel

IPC: B01D29/00 ,  B01D61/00

CPC classification number: B01D69/12 ,  A61M1/3633 ,  A61M1/3636 ,  B01D61/18 ,  B01D63/081 ,  B01D65/00

Abstract: A filter for removing leukocytes from blood comprises a filter media (20) enclosed in a housing (30). The filter media (20) includes a main filter region (MF) comprising a porous membrane structure extending between first and second skin surfaces. The porous membrane structure is formed by intersecting cells having a range of diameters. The cells adjacent to the first skin surface have diameters generally smaller than the diameters of the cells adjacent to the second skin surface. The first skin surface includes an open area defined by pores which are formed by the intersection of cells with the first skin surface. The majority of the open area is defined by pores having a diameter of between about 12 microns and 28 microns.