Abstract:
The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs, ethanol intoxication, or as a foodstuff. The novel pyruvate compound is particularly a pyruvate thiolester, a glycerol-pyruvate ester or a dihydroxyacetone-pyruvate ester.
Abstract:
A method for manufacturing an integral three-dimensional object (60) from laminations (48) includes the steps of fabricating a plurality of first sheets (44) of a first material composition, cuttting each of the first sheets to form a contoured layer (48) representing a cross section of the three-dimensional object and to form a waste material and discarding the waste material. The contoured layers are stacked in a desired sequence to form a stack (50) of contoured layers which are then laminated. Subsequently, the contoured layers of the stack are secured to each other to form the intergral three-dimensional object (60). This method works particularly well with ceramic material sheets (72). If desired, a second type of sheet (76) made of a fugitive material can also be cut to form a contoured layer representing a void in a cross section of the three-dimensional object. The contoured layers of the second sheets are then stacked along with the contoured layers of the first sheets to form the object. The laminated stack of contoured layers is then sintered. During processing, fugitive material can be removed, leaving voids in the three-dimensional object.
Abstract:
Compositions of matter which comprise a mixture of isolated muscle precursor cells with either isolated mesenchymal stem cells or isolated periosteum cells, optionally further including a myoinductive agent, a method for inducing isolated human mesenchymal stem cells to differentiate into myogenic cells, a method for producing dystrophin-positive myogenic cells in a mammal, a method for effecting muscle regeneration, and a method for treating muscular dystrophy are disclosed.
Abstract:
A polysilicon micromotor, of either inner rotor or outer rotor design, is fabricated with a process that uses as few as three mask steps. In an outer rotor (wobble) micromotor, a free-rotating insulating flange bearing (14) mechanically couples the inner periphery of the rotor (16) to the stator (12), permitting the outer periphery of the rotor to be directly coupled to other mechanisms. The dielectric constant of the flange bearing (14) increases motive torque of the motor as contrasted with air-gap designs. This and other factors result in motive torque, in the illustrated embodiment, more than 100 times larger than in previous designs. Among its other benefits, the disclosed fabrication process results in in-place formation of all motor elements, and enables precise definition of the rotor/stator gap.
Abstract:
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effet as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
Abstract:
The present invention relates to the development of a new class of oligonucleotide surrogates capable of sequence specific binding to simple stranded DNA and RNA as well as to double stranded DNA targets. More specifically, structures (Ser/Thr[CH2B]-AA[P])n below represent the repeating structural units for a number of the nucleic acid surrogates of the present invention. Once synthesized (in suitably protected form), the monobasic units are linked together via peptide bonds to produce the required oligomeric structures having defined nucleobase sequences. These nucleic acid surrogates may then be utilized for use as antisense/antigene probes and/or drug carriers.
Abstract translation:本发明涉及开发能够与单链DNA和RNA以及双链DNA靶序列特异性结合的新一类寡核苷酸替代物。 更具体地,结构(Ser / Thr [CH 2 B] -A A [P])n表示本发明的许多核酸替代物的重复结构单元。 一旦合成(合适的保护形式),单碱基单元通过肽键连接在一起,以产生具有确定的核碱基序列的所需寡聚结构。 然后可以将这些核酸替代物用作反义/反向探针和/或药物载体。
Abstract:
A self-curling sheet (A) of a nonconductive material is biased to curl into a tight cylinder. Inwardly extending conductive members (B) are disposed on the surface of the sheet forming the inside of the cylinder. Circumferentially separated longitudinal slices (30) are made in the cylinder adjacent the conductive members (B) forming spring members (52) such that, as the sheet (A) relaxes over time, electrodes (11) on the spring members (52) engage and pierce a nerve surrounded by the cuff. The conductive members (B) may be electrically conductive for applying electrical impulses or fluid conductive for infusing medications. In use, a first edge of the self-curling sheet (A) is disposed adjacent a nerve trunk which is to receive the cuff there around. The self-curling sheet (A) is controllably permitted to curl around the nerve into its original cylindrical shape. Over a period of a few days, the electrodes (11) riding on spring members (52) formed by longitudinal slices (30) into the cylinder are embedded in the nerve without damage to the perineurium membrane surrounding the nerve axons. The electrodes (11) displace the fascicles rather than damaging them by piercing the perineurium.
Abstract:
The present invention provides a biological bandage, comprising an envelope enclosing cells which secrete biologically active cellular products such as growth factors, which promote the healing of wounds. The envelope is further comprised of a permeable bottom membrane through which the cellular product diffuses, and a top membrane. Preferably the bandage has a separator interposed between the two membranes. One embodiment of this separator is seen in the figure. This invention also relates to a method for treating wounds. The bandage provides a continuous, uniform source of fresh cellular product.
Abstract:
The present invention relates to "activated" immature astrocytes and methods of utilizing the activated immature astrocytes to reduce secondary necrosis and scar formation in central nervous system tissue as well as to promote axon and/or blood vessel growth or regeneration. In specific embodiments of the invention, activated immature astrocytes are used in injectable form or on a polymer implant. The activated immature astrocytes and pharmaceutical compositions comprising same, may be used to treat disorders of the nervous system resulting from accidents or diseases which have in some way damaged the nerve tissue.
Abstract:
A method for casting solid polymer electrolyte membranes comprising proton conducting polymers stable at temperatures in excess of 100 DEG C directly from acid solution. The invention further relates to the enhanced performance of these membranes with respect to conductivity. Particularly, the invention relates to the use of trifluoroacetic acid (TFA) as an acid solvent doped with H3PO4 from which polybenzimiadazole (PBI) solid polymer electrolyte membranes may be cast.
Abstract translation:一种用于浇铸固体聚合物电解质膜的方法,其包括直接从酸溶液中在超过100℃的温度下稳定的质子传导聚合物。 本发明还涉及这些膜相对于导电性的增强的性能。 特别地,本发明涉及使用三氟乙酸(TFA)作为可以浇注聚苯并咪唑(PBI)固体聚合物电解质膜的H 3 PO 4的酸溶剂。