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    MICROMOTORS AND METHODS OF FABRICATION
    24.
    发明申请
    MICROMOTORS AND METHODS OF FABRICATION 审中-公开
    微型电机和制造方法

    公开(公告)号：WO1995034124A1

    公开(公告)日：1995-12-14

    申请号：PCT/US1994014798

    申请日：1994-12-22

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  MEHREGANY, Mehran ,  DENG, Keren

    IPC: H02N01/00

    CPC classification number: B81C1/00198 ,  B81B2201/034 ,  G02B26/0816 ,  G02B26/106 ,  H02N1/004

    Abstract: A polysilicon micromotor, of either inner rotor or outer rotor design, is fabricated with a process that uses as few as three mask steps. In an outer rotor (wobble) micromotor, a free-rotating insulating flange bearing (14) mechanically couples the inner periphery of the rotor (16) to the stator (12), permitting the outer periphery of the rotor to be directly coupled to other mechanisms. The dielectric constant of the flange bearing (14) increases motive torque of the motor as contrasted with air-gap designs. This and other factors result in motive torque, in the illustrated embodiment, more than 100 times larger than in previous designs. Among its other benefits, the disclosed fabrication process results in in-place formation of all motor elements, and enables precise definition of the rotor/stator gap.

    Abstract translation: 内部转子或外部转子设计的多晶硅微型电动机的制造采用仅使用三个掩模步骤的工艺。 在外转子（摆动）微型马达中，自由旋转的绝缘法兰轴承（14）将转子（16）的内周机械地联接到定子（12），允许转子的外周直接与其它 机制。 与气隙设计相反，法兰轴承（14）的介电常数增加了电动机的动力转矩。 在所示实施例中，这个和其他因素导致动力转矩比以前的设计大100倍以上。 在其它优点之中，所公开的制造过程导致所有电机元件的就地形成，并且能够精确地定义转子/定子间隙。

    PEPTIDE-BASED NUCLEIC ACID SURROGATES
    26.
    发明申请
    PEPTIDE-BASED NUCLEIC ACID SURROGATES 审中-公开
    基于肽的核酸SODOGATES

    公开(公告)号：WO1995011909A1

    公开(公告)日：1995-05-04

    申请号：PCT/US1994011445

    申请日：1994-10-07

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  GARNER, Philip, P.

    IPC: C07H17/00

    CPC classification number: C07K14/003

    Abstract: The present invention relates to the development of a new class of oligonucleotide surrogates capable of sequence specific binding to simple stranded DNA and RNA as well as to double stranded DNA targets. More specifically, structures (Ser/Thr[CH2B]-AA[P])n below represent the repeating structural units for a number of the nucleic acid surrogates of the present invention. Once synthesized (in suitably protected form), the monobasic units are linked together via peptide bonds to produce the required oligomeric structures having defined nucleobase sequences. These nucleic acid surrogates may then be utilized for use as antisense/antigene probes and/or drug carriers.

    Abstract translation: 本发明涉及开发能够与单链DNA和RNA以及双链DNA靶序列特异性结合的新一类寡核苷酸替代物。 更具体地，结构（Ser / Thr [CH 2 B] -A A [P]）n表示本发明的许多核酸替代物的重复结构单元。 一旦合成（合适的保护形式），单碱基单元通过肽键连接在一起，以产生具有确定的核碱基序列的所需寡聚结构。 然后可以将这些核酸替代物用作反义/反向探针和/或药物载体。

    SLOWLY PENETRATING INTER-FASCICULAR NERVE CUFF ELECTRODE
    27.
    发明申请
    SLOWLY PENETRATING INTER-FASCICULAR NERVE CUFF ELECTRODE 审中-公开
    慢速穿透心脏内神经元电极

    公开(公告)号：WO1995010227A1

    公开(公告)日：1995-04-20

    申请号：PCT/US1994011671

    申请日：1994-10-13

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  DURAND, Dominique, M. ,  TYLER, Dustin, J.

    IPC: A61B05/04

    CPC classification number: A61N1/0556 ,  Y10T29/49117

    Abstract: A self-curling sheet (A) of a nonconductive material is biased to curl into a tight cylinder. Inwardly extending conductive members (B) are disposed on the surface of the sheet forming the inside of the cylinder. Circumferentially separated longitudinal slices (30) are made in the cylinder adjacent the conductive members (B) forming spring members (52) such that, as the sheet (A) relaxes over time, electrodes (11) on the spring members (52) engage and pierce a nerve surrounded by the cuff. The conductive members (B) may be electrically conductive for applying electrical impulses or fluid conductive for infusing medications. In use, a first edge of the self-curling sheet (A) is disposed adjacent a nerve trunk which is to receive the cuff there around. The self-curling sheet (A) is controllably permitted to curl around the nerve into its original cylindrical shape. Over a period of a few days, the electrodes (11) riding on spring members (52) formed by longitudinal slices (30) into the cylinder are embedded in the nerve without damage to the perineurium membrane surrounding the nerve axons. The electrodes (11) displace the fascicles rather than damaging them by piercing the perineurium.

    Abstract translation: 非导电材料的自卷曲片（A）被偏压以卷曲成紧密的圆柱体。 向内延伸的导电构件（B）设置在形成气缸内部的薄片的表面上。 周向分开的纵向切片（30）在与形成弹簧构件（52）的导电构件（B）相邻的圆柱体中制成，使得随着片材（A）随着时间的推移而松弛，弹簧构件（52）上的电极（11）接合 并刺穿由袖口包围的神经。 导电构件（B）可以是导电的，用于施加电脉冲或用于输注药物的流体导电。 在使用中，自卷曲片（A）的第一边缘邻近于在其周围接收袖带的神经干线。 自动卷曲片（A）可控制地卷绕在原来的圆柱形状的神经周围。 在几天的时间内，将由纵向切片（30）形成的弹簧部件（52）上的电极（12）嵌入到圆筒中，而不会损伤神经轴突周围的神经束膜。 电极（11）移动束筒，而不是通过刺穿围网来破坏它们。

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