公开(公告)号：CA3013636A1

公开(公告)日：2017-09-14

申请号：CA3013636

申请日：2017-02-17

Applicant: CYTOSORBENTS CORP

Inventor： GRUDA MARYANN ,  O'SULLIVAN PAMELA ,  GULIASHVILI TAMAZ ,  SCHEIRER ANDREW ,  GOLOBISH THOMAS ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61K9/18 ,  A61M1/00 ,  B01J20/22 ,  B01J20/28 ,  B01J20/285

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

公开(公告)号：CA3001698A1

公开(公告)日：2017-04-27

申请号：CA3001698

申请日：2016-10-21

Applicant: CYTOSORBENTS CORP

Inventor： GOLOBISH THOMAS ,  GRUDA MARYANN ,  GULIASHVILI TAMAZ ,  O'SULLIVAN PAMELA ,  SCHEIRER ANDREW ,  DAN VI ,  YOUNG WEI-TAI ,  CAPPONI VINCENT ,  CHAN PHILLIP

IPC: A61M5/165 ,  A61K31/795 ,  A61K47/20 ,  A61M1/34

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.