公开(公告)号：EP2515959A1

公开(公告)日：2012-10-31

申请号：EP10803559.3

申请日：2010-12-21

Applicant: Coloplast A/S

Inventor： NIELSEN, Bo Rud ,  SCHOENFELDT, Lars ,  MADSEN, Niels Joergen

IPC: A61L29/08 ,  A61L31/10 ,  A61L2/08

CPC classification number: A61L2/08 ,  A61L2/081 ,  A61L2/087 ,  A61L27/16 ,  A61L27/34 ,  A61L29/041 ,  A61L29/085 ,  A61L31/048 ,  A61L31/10 ,  C08L39/06

Abstract: Medical device comprising a hydrophilic coating, sterilised while in contact with a swelling medium comprising a low molecular polyol; and a separate buffer selected from the group consisting of carboxylic acids, amino acids, aminosulphonic acids and inorganic acids. The swelling media provides a stable pH after sterilisation and maintain the low friction of the coating.

Abstract translation: 包含亲水涂层的医疗装置，与包含低分子多元醇的溶胀介质接触时灭菌; 和选自羧酸，氨基酸，氨基磺酸和无机酸的单独缓冲液。 溶胀介质在灭菌后提供稳定的pH，并保持涂层的低摩擦。

公开(公告)号：EP2104523A1

公开(公告)日：2009-09-30

申请号：EP07857618.8

申请日：2007-12-14

Applicant: Coloplast A/S

Inventor： NIELSEN, Bo Rud ,  HØJ, Carsten ,  NIELSEN, Christian Benedikt ,  MADSEN, Niels Jørgen

IPC: A61L31/10 ,  A61L27/34 ,  A61L27/48 ,  C08J3/24 ,  C08L71/02

CPC classification number: A61L29/085 ,  A61L17/145 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/10 ,  C08G65/331 ,  C08J7/047 ,  C08J7/123 ,  C08J2471/00 ,  C08L23/36 ,  C08L71/02 ,  C09D171/02 ,  C08L2666/04

Abstract: The application discloses a method for the preparation (by extruding, injection moulding or powder coating and subsequent cross-linking by irradiation with UV or visible light) of a medical device element involving a coating composition comprising: a) as the only polymer constituent(s), at least 50 % by weight of poly(ethylene oxide)(s) optionally in combination with non-thermoplastic hydrophilic polymer(s), and b) low molecular weight scaffold(s) having a plurality of photo-initiator moieties covalently linked thereto and/or covalently incorporated therein, wherein the photo-initiator moieties constitute 0.01-20 % by weight of the combined amount of the poly(ethylene oxide)(s), any non-thermoplastic hydrophilic polymers and the low molecular weight scaffolds. The application further discloses such extruded, injection moulded or powder coated medical devices having thereon a layer of a covalently cross-linked coating composition of a poly(ethylene oxide) (PEO), optionally a non-thermoplastic hydrophilic polymer and a low molecular weight scaffold having a plurality of residues of photo-initiator moieties.

公开(公告)号：EP2049172A2

公开(公告)日：2009-04-22

申请号：EP07787894.0

申请日：2007-07-25

Applicant: Coloplast A/S

Inventor： MADSEN, Niels Jørgen ,  TRIEL, Egon ,  NIELSEN, Bo Rud ,  HØJ, Carsten

IPC: A61L31/10

CPC classification number: B05D3/067 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L31/14 ,  B05D5/08 ,  B05D2201/00 ,  B29C45/0053 ,  B29C45/14 ,  B29C45/1679 ,  B29C47/0023 ,  B29C47/021 ,  B29C71/04 ,  B29C2035/0827 ,  B29C2045/0075 ,  B29K2023/06 ,  B29K2023/083 ,  B29K2023/086 ,  B29K2075/00 ,  B29K2077/00 ,  B29K2995/0092 ,  B29L2031/753 ,  B29L2031/7542 ,  C08G18/4833 ,  C08G18/83 ,  C08G65/331 ,  C08G65/3324 ,  C08G2210/00 ,  Y10T428/31511 ,  Y10T428/31551 ,  Y10T428/31786

Abstract: The present invention relates to a method for the preparation of a medical device element by means of extrusion or injection moulding and to medical devices comprising such extruded or injection moulded medical device elements. The medical device elements (e.g. tubes, wires, lines, stents, catheters, guides, endodontic instruments, needles, trocars for e.g. laparoscopic surgery, laparoscopic accessories, surgical instruments, guide wires) are characterized by a prefabricated shaped article or a thermoplastic substrate polymer having thereon a layer of a covalently cross-linked coating composition of a thermoplastic matrix polymer and a hydrophilic polymer. The method involves a coating composition comprising a thermoplastic matrix polymer, a hydrophilic polymer, and one or more photo-initiator(s), e.g. covalently linked to molecules of the thermoplastic matrix polymer and/or to molecules of the hydrophilic polymer. The coating composition is irradiated with UV or visible light so as to covalently cross-link said coating composition.

公开(公告)号：EP1599248A2

公开(公告)日：2005-11-30

申请号：EP04714725.1

申请日：2004-02-26

Applicant: COLOPLAST A/S

Inventor： NIELSEN, Bo Rud ,  KRISTIANSEN, Soren ,  BRUUN, Bo Kjellman ,  SIDENIUS, Martin

IPC: A61M25/00

CPC classification number: A61M25/0017 ,  A61K33/40 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/404 ,  A61M25/002 ,  A61M25/0045 ,  A61M2025/0056 ,  C08L39/06

Abstract: The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).