公开(公告)号：WO2004075944A2

公开(公告)日：2004-09-10

申请号：PCT/DK2004/000129

申请日：2004-02-26

Applicant: COLOPLAST A/S ,  NIELSEN, Bo Rud ,  KRISTIANSEN, Søren ,  BRUUN, Bo Kjellman ,  SIDENIUS, Martin

Inventor： NIELSEN, Bo Rud ,  KRISTIANSEN, Søren ,  BRUUN, Bo Kjellman ,  SIDENIUS, Martin

IPC: A61M

CPC classification number: A61M25/0017 ,  A61K33/40 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/404 ,  A61M25/002 ,  A61M25/0045 ,  A61M2025/0056 ,  C08L39/06

Abstract: The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).

Abstract translation: 本发明提供了一种用于制备具有包含过氧化氢的多孔涂层的医疗装置的组件。 特别有趣的医疗设备是导管（例如导尿管），内窥镜，喉镜，用于进食的管，排水管，导丝，避孕套，尿囊，屏障涂层等。 手套，支架和其他植入物，额外的体液血管，膜例如。 用于透析，血液过滤器，循环辅助装置，伤口护理敷料和造口袋。 涂层特别是由交联聚乙烯吡咯烷酮形成的亲水涂层。 在一个实施例中，组件将干燥的导管元件保持在包装的一个隔室中，并且在另一隔室中保持过氧化氢水溶液。 溶液也可以包括稳定剂，例如 螯合剂和渗透压增加剂。 用于插入尿道的导管可用于治疗，缓解或预防微生物感染如尿路感染（UTI）。

公开(公告)号：WO2006069579A2

公开(公告)日：2006-07-06

申请号：PCT/DK2005/000830

申请日：2005-12-23

Applicant: COLOPLAST A/S ,  NIELSEN, Bo Rud ,  MADSEN, Niels, Joergen

Inventor： NIELSEN, Bo Rud ,  MADSEN, Niels, Joergen

CPC classification number: A61L31/141 ,  A61L29/085 ,  A61L29/141 ,  A61L31/10 ,  C08J7/047 ,  C08J2375/04 ,  C08J2439/00 ,  C08K5/435 ,  C08L2203/02 ,  C09D139/06 ,  C08L39/06

Abstract: The present invention provides a medical device having a substrate polymer surface carrying thereon a hydrophilic coating comprising a cross-linked hydrophilic polymer and ptoluenesfulfonamide, and a method for the preparation thereof.

Abstract translation: 本发明提供了一种具有基材聚合物表面的医疗装置及其制备方法，所述基材聚合物表面上带有包含交联的亲水性聚合物和对甲苯磺酰脲的亲水涂层。

公开(公告)号：WO2013170859A2

公开(公告)日：2013-11-21

申请号：PCT/DK2013/050145

申请日：2013-05-14

Applicant: COLOPLAST A/S

Inventor： MADSEN, Niels Jørgen ,  SEHNAL, Petr ,  ANDERSON, David George ,  NIELSEN, Bo Rud

IPC: C07C49/84 ,  C08F4/00 ,  C08G83/00 ,  C07C49/786 ,  C07D335/16 ,  C08F2/50 ,  C07C219/14 ,  C07C225/16 ,  C08F220/18 ,  C08G18/32 ,  C07D295/088 ,  C07C217/22

CPC classification number: C08G18/6674 ,  C07C217/54 ,  C08F2/50 ,  C08F120/18 ,  C08G18/3215 ,  C08G18/4833 ,  C08G18/72 ,  C08G18/73 ,  C08J3/24 ,  C08J3/28 ,  C08J2375/08

Abstract: The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as the photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure.

Abstract translation: 本发明提供了聚合物光引发剂，其是光引发剂单体和至少一种另外的单体的共聚物，以及光引发剂单体是制备这种聚合物光引发剂的中间体。 此外，提供了在这种聚合物光引发剂的存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。 在光引发剂单体和聚合物光引发剂中，将光引发剂部分和叔胺引入光引发剂结构中。

公开(公告)号：WO2013170858A1

公开(公告)日：2013-11-21

申请号：PCT/DK2013/050144

申请日：2013-05-14

Applicant: COLOPLAST A/S

Inventor： MADSEN, Niels Jørgen ,  SEHNAL, Petr ,  ANDERSON, David George ,  NIELSEN, Bo Rud

IPC: C08F2/50

CPC classification number: C08F2/50 ,  C07C49/84 ,  C07C69/738 ,  C08G18/3215 ,  C08G18/4833 ,  C08G18/6674 ,  C08G18/73 ,  C08G63/00 ,  G03F7/0384

Abstract: The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerisable functional groups are incorporated into the photoinitiator structure.

Abstract translation: 本发明提供了作为光引发剂单体和至少一种其它单体的共聚物的聚合物光引发剂，以及光引发剂单体是制备这种聚合物光引发剂的中间体。 此外，提供了在这种聚合物光引发剂存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。 在光引发剂单体和聚合光引发剂中，光引发剂部分，水解稳定的连接体和两个可聚合的官能团引入光引发剂结构中。

公开(公告)号：EP2726140A1

公开(公告)日：2014-05-07

申请号：EP12732780.7

申请日：2012-06-29

Applicant: Coloplast A/S

Inventor： NIELSEN, Bo Rud

IPC: A61M25/10 ,  A61M25/00

CPC classification number: A61M27/00 ,  A61M25/0017 ,  A61M25/0043 ,  A61M25/10 ,  A61M2025/006

Abstract: A catheter with a balloon element is provided with ribs under the balloon element so as to prevent the balloon from being attached to the shaft of the catheter to an extent where the balloon is difficult to inflate. The number of ribs can be any number above 3, but 6 to16 ribs are preferred.

Abstract translation: 具有球囊元件的导管在球囊元件下方设置有肋，以便防止气囊附着到导管的轴上至气囊难以膨胀的程度。 肋的数量可以是3以上的任何数，但优选6至16个肋。

公开(公告)号：EP2394676B1

公开(公告)日：2018-03-28

申请号：EP11177367.7

申请日：2007-12-14

Applicant: Coloplast A/S

Inventor： NIELSEN, Bo Rud ,  HOEJ, Carsten ,  NIELSEN, Christian B. ,  MADSEN, Niels Joergen

IPC: A61L29/08 ,  A61L17/14 ,  C08J7/04 ,  C08J7/12 ,  C08G65/331 ,  A61L27/34 ,  A61L31/10 ,  C09D171/02 ,  C08L23/36 ,  C08L71/02

CPC classification number: A61L29/085 ,  A61L17/145 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/10 ,  C08G65/331 ,  C08J7/047 ,  C08J7/123 ,  C08J2471/00 ,  C08L23/36 ,  C08L71/02 ,  C09D171/02 ,  C08L2666/04

Abstract: The application discloses a method for the preparation (by extruding, injection moulding or powder coating and subsequent cross-linking by irradiation with UV or visible light) of a medical device element involving a coating composition comprising (a) as the only polymer constituent(s), at least 50 % by weight of poly(ethylene oxide)(s) optionally in combination with non-thermoplastic hydrophilic polymer(s), and (b) low molecular weight scaffold(s) having a plurality of photo-initiator moieties covalently linked thereto and/or covalently incorporated therein, wherein the photo-initiator moieties constitute 0.01-20 % by weight of the combined amount of the poly(ethylene oxide)(s), any non-thermoplastic hydrophilic polymers and the low molecular weight scaffolds. The application further discloses such extruded, injection moulded or powder coated medical devices having thereon a layer of a covalently cross-linked coating composition of a poly(ethylene oxide) (PEO), optionally a non-thermoplastic hydrophilic polymer and a low molecular weight scaffold having a plurality of residues of photo-initiator moieties.

公开(公告)号：EP1833889A2

公开(公告)日：2007-09-19

申请号：EP05823023.6

申请日：2005-12-23

Applicant: COLOPLAST A/S

Inventor： NIELSEN, Bo Rud ,  MADSEN, Niels, Joergen

IPC: C08J7/04

CPC classification number: A61L31/141 ,  A61L29/085 ,  A61L29/141 ,  A61L31/10 ,  C08J7/047 ,  C08J2375/04 ,  C08J2439/00 ,  C08K5/435 ,  C08L2203/02 ,  C09D139/06 ,  C08L39/06

Abstract: The present invention provides a medical device having a substrate polymer surface carrying thereon a hydrophilic coating comprising a cross-linked hydrophilic polymer and ptoluenesfulfonamide, and a method for the preparation thereof.

Abstract translation: 本发明提供一种具有聚合物基底表面在其上的亲水性涂层，其包含交联的亲水性聚合物和对甲苯磺酰胺，和其制备的方法携带的医疗装置。

公开(公告)号：EP2850112A2

公开(公告)日：2015-03-25

申请号：EP13724725.0

申请日：2013-05-14

Applicant: Coloplast A/S

Inventor： MADSEN, Niels Jørgen ,  SEHNAL, Petr ,  ANDERSON, David George ,  NIELSEN, Bo Rud

IPC: C08F2/50 ,  C08G71/00

CPC classification number: C08G18/6674 ,  C07C217/54 ,  C08F2/50 ,  C08F120/18 ,  C08G18/3215 ,  C08G18/4833 ,  C08G18/72 ,  C08G18/73 ,  C08J3/24 ,  C08J3/28 ,  C08J2375/08

Abstract: The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as the photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure.

Abstract translation: 本发明提供聚合物光引发剂，其是光引发剂单体和至少一种其它单体的共聚物，以及光引发剂单体是制备这种聚合物光引发剂的中间体。 此外，提供了在这种聚合物光引发剂的存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。 在光引发剂单体和聚合光引发剂中，光引发剂部分和叔胺被引入光引发剂结构中。

公开(公告)号：EP1599248B1

公开(公告)日：2010-06-02

申请号：EP04714725.1

申请日：2004-02-26

Applicant: Coloplast A/S

Inventor： NIELSEN, Bo Rud ,  KRISTIANSEN, Soren ,  BRUUN, Bo Kjellman ,  SIDENIUS, Martin

IPC: A61M25/00

CPC classification number: A61M25/0017 ,  A61K33/40 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/404 ,  A61M25/002 ,  A61M25/0045 ,  A61M2025/0056 ,  C08L39/06

Abstract: The present invention provides an assembly for the preparation of a medical device having a porous coating comprising hydrogen peroxide. Particularly interesting medical devices are catheters (such as urinary catheters), endoscopes, laryngoscopes, tubes for feeding, tubes for drainage, guide wires, condoms, urisheaths, barrier coatings e.g. for gloves, stents and other implants, extra corporeal blood conduits, membranes e.g. for dialysis, blood filters, devices for circulatory assistance, dressings for wound care, and ostomy bags. The coating is in particular a hydrophilic coating formed from cross-linked polyvinylpyrrolidone. In one embodiment, the assembly holds a dry catheter element in one compartment of a package and an aqueous hydrogen peroxide solution in another compartment. The solution may also comprise stabilizers, e.g. chelators, and osmolality increasing agents. The catheter for insertion in the urethra is useful for the treatment, alleviation or prophylaxis of microbial infections such as urinary tract infections (UTI).

Abstract translation: 对本发明的组件提供了具有多孔涂层，其包含过氧化氢的医疗装置的制备。 特别有趣的医疗装置是导管（：如导尿管），内窥镜，喉镜，管喂养，管的排水，导丝，避孕套，urisheaths，阻挡涂层E.G. 手套，支架和其他植入物，额外的体外血液导管，膜E.G. 透析，血液过滤器，用于循环辅助设备，敷料伤口护理和造瘘袋。 该涂层特别是从交联的聚乙烯吡咯烷酮而形成的亲水性涂层。 在一个中，实施例组件保持在封装中的一个隔室的干燥导管元件和wässrige在另一隔室的过氧化氢溶液。 因此，该溶液可包含稳定剂，E.G. 螯合剂，以及渗透压增加剂。 用于插入尿道导管为微生物感染的治疗，缓解或预防是有用的：如尿路感染（UTI）。

公开(公告)号：WO2013170857A1

公开(公告)日：2013-11-21

申请号：PCT/DK2013/050143

申请日：2013-05-14

Applicant: COLOPLAST A/S

Inventor： MADSEN, Niels Jørgen ,  SEHNAL, Petr ,  ANDERSON, David George ,  NIELSEN, Bo Rud

IPC: C08F4/00 ,  C08G83/00 ,  C08F2/50

CPC classification number: C08G18/6688 ,  C07C217/54 ,  C07D335/16 ,  C08F2/48 ,  C08F2/50 ,  C08F4/04 ,  C08F20/18 ,  C08F22/105 ,  C08G18/0814 ,  C08G18/3275 ,  C08G18/4833 ,  C08G18/73 ,  C08G18/758 ,  C09D4/00 ,  C08F220/20

Abstract: The present invention provides polymeric quaternary ammonium photoinitiators being co-polymers of photoinitiator monomers, as well as quaternary ammonium photoinitiator monomer being valuable intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided a polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a quaternary ammonium are incorporated into the photoinitiator structure.

Abstract translation: 本发明提供聚合季铵光引发剂，其是光引发剂单体的共聚物，以及季铵光引发剂单体，作为制备这种聚合物光引发剂的有价值的中间体。 另外，提供了在这种聚合物光引发剂的存在下通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。 在光引发剂单体和聚合光引发剂中，光引发剂部分和季铵加入到光引发剂结构中。