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    DEGRADABLE HYDROPHILIC BLOCK COPOLYMERS WITH IMPROVED BIOCOM PATIBIL FOR SOFT TISSUE REGENERATION
    22.
    发明授权
    DEGRADABLE HYDROPHILIC BLOCK COPOLYMERS WITH IMPROVED BIOCOM PATIBIL FOR SOFT TISSUE REGENERATION 有权
    可降解亲水嵌段共聚物，具有改善的生物相容性，用于软组织再生

    公开(公告)号：EP1996643B1

    公开(公告)日：2010-02-24

    申请号：EP07711258.9

    申请日：2007-03-07

    Applicant: Coloplast A/S

    Inventor： VANGE, Jakob ,  SCHWACH-ABDELLAOUI, Khadija ,  EVERLAND, Hanne ,  NIELSEN, Peter, Sylvest ,  NIELSEN, Brian ,  JESPERSEN, Lene, Karin ,  NIELSEN, Lene, Feldskov

    IPC: C08G63/664 ,  C08G81/00 ,  C08J9/00 ,  C08J9/28 ,  A61L27/18 ,  A61L15/26 ,  A61L27/56

    CPC classification number: C08G63/664 ,  A61L15/26 ,  A61L15/425 ,  A61L27/18 ,  A61L27/56 ,  C08G2261/126 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2201/0484 ,  C08J2367/04 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/40 ,  Y10T428/249958 ,  C08L67/04

    Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O-(CHR1CHR2O)n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [-CH(CH3)-COO-] and (ii) glycolide units [-CH2-COO-] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR1CHR2O)-] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

    Abstract translation: 本申请公开了可生物降解的聚合物，包含这种聚合物的多孔材料和其他材料，以及这些材料的各种医学用途，包括用作支持细胞粘附或组织再生的向内生长的支架。 （i）丙交酯单元[-CH（CH 3）-COO-]和（ii）乙交酯的摩尔比为1:1，聚合物具有式AO-（CHR 1 CHR 2 O）n B，其中A为丙交酯 - 乙交酯共聚物残基。 （丙交酯 - 共 - 乙交酯）残基中的单元[-CH 2 -COO-]为80:20至10:90，B为聚（丙交酯 - 共 - 乙交酯）残基或氢， 6-烷基或羟基保护基，R 1和R 2之一是氢或甲基，另一个是氢，n是10-1000，（iii）聚亚烷基二醇单元[ - （CHR 1 CHR 2 O） - ]与组合 （丙交酯 - 共 - 乙交酯）残基中的（i）丙交酯单元和（ii）乙交酯单元的量最多为14:86，并且共聚物的分子量为至少20,000g / mol。

    BIODEGRADABLE SCAFFOLD WITH ECM MATERIAL
    25.
    发明公开
    BIODEGRADABLE SCAFFOLD WITH ECM MATERIAL 无效
    生物学家ABBAUBARESGERÜSTMIT ECM-MATERIAL

    公开(公告)号：EP1942957A2

    公开(公告)日：2008-07-16

    申请号：EP06807590.2

    申请日：2006-10-26

    Applicant: Coloplast A/S

    Inventor： NIELSEN, Peter Sylvest ,  NIELSEN, Brian ,  JESPERSEN, Lene Karin ,  EVERLAND, Hanne ,  NIELSEN, Lene Feldskov

    IPC: A61L15/00

    CPC classification number: A61L27/3633 ,  A61L27/56 ,  A61L27/58

    Abstract: We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth.

    Abstract translation: 我们将Extra Cellular Matrix（ECM）的不连续区域添加到可生物降解的支架中。 因此，可以将支架可提供的物理范围与ECM的重建性质相结合。 公开了每种应用的离散ECM材料的最佳量，并且该浓度均匀分布在敷料中，从而避免不必要的高浓度的ECM。 除了ECM的作用之外，基体材料的多孔结构为细胞提供了用于生长的结构。

    A WOUND DRESSING
    26.
    发明公开
    A WOUND DRESSING 审中-公开
    伤口敷料

    公开(公告)号：EP1610830A1

    公开(公告)日：2006-01-04

    申请号：EP04722805.1

    申请日：2004-03-24

    Applicant: COLOPLAST A/S

    Inventor： NIELSEN, Brian ,  SEVERIN, Maria

    IPC: A61L15/28 ,  A61L15/44 ,  A61L15/60

    CPC classification number: A61L15/60 ,  A61L15/28 ,  A61L15/44 ,  A61L2300/104 ,  A61L2300/402 ,  A61L2300/404

    Abstract: A wound dressing comprising a web of gel-forming fibers or fibers soluble in wound exudates, attached to a reinforcing layer wherein the density of the web is in the range of 5-60 g/m2. The dressing may serve as a wound-contacting layer, providing moist wound healing combined with easy, non-traumatic removal from the wound site. The dressing may further comprise one or more active ingredients.

    Abstract translation: 一种伤口敷料，其包含可溶于伤口渗出物的凝胶形成纤维或纤维网，其连接至增强层，其中网的密度为5-60g / m 2。 敷料可以用作伤口接触层，提供湿伤口愈合，以及从伤口部位轻易的非创伤性移除。 该敷料可以进一步包含一种或多种活性成分。

    WOUND CARE DEVICE
    28.
    发明公开
    WOUND CARE DEVICE 有权
    含壳聚糖文章伤口处理

    公开(公告)号：EP1221984A1

    公开(公告)日：2002-07-17

    申请号：EP00965854.3

    申请日：2000-10-04

    Applicant: COLOPLAST A/S

    Inventor： NIELSEN, Brian

    IPC: A61L15/28 ,  A61L15/60

    CPC classification number: A61L15/60 ,  A61L15/28 ,  C08L5/08

    Abstract: Wound care device comprising chitosan, said chitosan being capable of absorbing liquid to form a swollen, coherent gel, and said chitosan being in the form of fibres having been modified by treatment with acid in a solvent which is not able to dissolve the chitosan fibres and by treatment with heat.

    WOUND CARE DEVICE COMPRISING CHITOSAN
    29.
    发明授权
    WOUND CARE DEVICE COMPRISING CHITOSAN 有权
    含壳聚糖文章伤口处理

    公开(公告)号：EP1221984B1

    公开(公告)日：2009-08-26

    申请号：EP00965854.3

    申请日：2000-10-04

    Applicant: Coloplast A/S

    Inventor： NIELSEN, Brian

    IPC: A61L15/28 ,  A61L15/60

    CPC classification number: A61L15/60 ,  A61L15/28 ,  C08L5/08

    Abstract: Wound care device comprising chitosan, said chitosan being capable of absorbing liquid to form a swollen, coherent gel, and said chitosan being in the form of fibres having been modified by treatment with acid in a solvent which is not able to dissolve the chitosan fibres and by treatment with heat.

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