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    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    23.
    发明专利
    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 未知

    公开(公告)号：CA2759994C

    公开(公告)日：2019-06-11

    申请号：CA2759994

    申请日：2010-04-30

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12N1/15 ,  C12N1/19 ,  C12N1/20 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N15/52 ,  C12N15/53 ,  C12P7/18

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3- BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4- hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA- dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    Organisms for the production of 1,3-butanediol
    28.
    发明专利
    Organisms for the production of 1,3-butanediol 未知

    公开(公告)号：AU2010242789B2

    公开(公告)日：2016-03-10

    申请号：AU2010242789

    申请日：2010-04-30

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12N1/20 ,  C12P7/16 ,  C12P7/18

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3- BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4- hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA- dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    Methods for the synthesis of acrylic acid and derivatives from fumaric acid
    30.
    发明专利
    Methods for the synthesis of acrylic acid and derivatives from fumaric acid 未知

    公开(公告)号：AU2014202721A1

    公开(公告)日：2014-06-12

    申请号：AU2014202721

    申请日：2014-05-19

    Applicant: GENOMATICA INC

    Inventor： BURK MARK J ,  PHARKYA PRITI ,  VAN DIEN STEPHEN J ,  BURGARD ANTHONY P ,  SCHILLING CHRISTOPHER H

    IPC: C07C51/347 ,  C07C57/04 ,  C07C67/333 ,  C07C69/54 ,  C12P7/46

    Abstract: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided. 5401428_1 (GHMallers) P83455AU.1

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