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    MICROORGANISMS FOR PRODUCING 1,3-BUTANEDIOL AND METHODS RELATED THERETO
    2.
    发明申请
    MICROORGANISMS FOR PRODUCING 1,3-BUTANEDIOL AND METHODS RELATED THERETO 审中-公开
    用于生产1,3-丁二醇的微生物及其相关方法

    公开(公告)号：WO2012177619A3

    公开(公告)日：2014-05-01

    申请号：PCT/US2012043117

    申请日：2012-06-19

    Applicant: GENOMATICA INC ,  BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

    Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

    IPC: C12P1/00 ,  C12N1/00 ,  C12N15/70 ,  C12N15/74

    CPC classification number: C12P7/18 ,  C12N15/52

    Abstract: Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3 -BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3 -BDO pathway enzyme expressed in a sufficient amount to produce 1,3 -BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    Abstract translation: 本文提供了具有1,3-丁二醇（1,3-BOD）途径的非天然存在的微生物生物，并且包含至少一种编码1,3 -BDO途径酶的外源核酸，其以足够的量表达以产生1 ，3 -BDO。 在一些实施方案中，该途径包括从CO或氢中还原当量。 在某些实施方案中，1,3-BDO途径通过中枢代谢物丙酮酸，琥珀酸或α-酮戊二酸进行。 本文还提供了一种生产1,3-BDO的方法，包括在条件和足够的时间内培养这些微生物以产生1,3-BDO。

    MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID
    4.
    发明申请
    MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID 审中-公开
    用于生产甲基丙烯酸的微生物

    公开(公告)号：WO2009135074A2

    公开(公告)日：2009-11-05

    申请号：PCT/US2009042426

    申请日：2009-04-30

    Applicant: GENOMATICA INC ,  BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12P7/52 ,  C12N1/00 ,  C12P7/40

    CPC classification number: C12P7/42 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/88 ,  C12N9/90 ,  C12P7/40 ,  C12Y102/01 ,  C12Y206/01022 ,  C12Y403/01 ,  C12Y504/99002

    Abstract: The invention provides a non-naturally occurring microbial organism having a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3- hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.

    Abstract translation: 本发明提供了具有2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径的非天然存在的微生物生物。 微生物生物体含有编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径中的酶的至少一种外源核酸。 本发明还提供了2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸的制备方法。 该方法可以包括培养足够量的表达至少一种编码2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸途径酶的外源核酸的2-羟基异丁酸，3-羟基异丁酸或产生甲基丙烯酸的微生物，并培养 在条件下和足够的时间内产生2-羟基异丁酸，3-羟基异丁酸或甲基丙烯酸。

    MICROORGANISMS FOR PRODUCING METHACRYLIC ACID AND METHACRYLATE ESTERS AND METHODS RELATED THERETO
    6.
    发明申请
    MICROORGANISMS FOR PRODUCING METHACRYLIC ACID AND METHACRYLATE ESTERS AND METHODS RELATED THERETO 审中-公开
    生产甲基丙烯酸和甲基丙烯酸酯的微生物及其相关方法

    公开(公告)号：WO2012135789A3

    公开(公告)日：2014-05-01

    申请号：PCT/US2012031733

    申请日：2012-03-30

    Applicant: GENOMATICA INC ,  BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

    Inventor： BURK MARK J ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

    IPC: C12P7/52 ,  C12N1/00

    CPC classification number: C12P7/40 ,  C12P7/42 ,  C12P7/62 ,  C12P19/32

    Abstract: The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2- hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.

    Abstract translation: 本发明提供具有甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯途径的非天然存在的微生物生物。 微生物生物体含有编码甲基丙烯酸途径中的酶的至少一种外源核酸。 本发明另外提供了生产甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的方法。 该方法可以包括培养产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的微生物，其中微生物生物体表达至少一种编码甲基丙烯酸途径酶的外源核酸，其量足以产生甲基丙烯酸， 甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯在条件下和足够的时间以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯。

    MICROORGANISMS FOR PRODUCING ISOBUTANOL AND METHODS RELATED THERETO
    10.
    发明申请
    MICROORGANISMS FOR PRODUCING ISOBUTANOL AND METHODS RELATED THERETO 审中-公开
    用于生产ISOBUTANOL的微生物及其相关方法

    公开(公告)号：WO2012177601A3

    公开(公告)日：2014-05-08

    申请号：PCT/US2012043091

    申请日：2012-06-19

    Applicant: GENOMATICA INC ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

    Inventor： BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  SUN JUN ,  PHARKYA PRITI

    IPC: C07C29/00 ,  C12N1/00 ,  C12N1/20 ,  C12P7/16

    CPC classification number: C12P7/16 ,  C12N15/52 ,  Y02E50/10

    Abstract: Provided herein is a non-naturally occurring microbial organism having an isopropanol pathway and comprising at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. In certain embodiments, the pathway includes an enzyme selected from a 4-hydroxybutyryl-CoA dehydratase, a crotonase, a 3-hydroxybutyryl-CoA dehydrogenase, an acetoacetyl-CoA synthetase, an acetyl-CoA:acetoacetate-CoA transferase, an acetoacetyl-CoA hydrolase, an acetoacetate decarboxylase, and an acetone reductase. Also provided herein is anon-naturally occurring microbial organism having an n-butanol pathway and comprising at least one exogenous nucleic acid encoding an n-butanol pathway enzyme. Other non-naturally occurring microbial organism having n-butanol or isobutanol pathways are also provided herein. In certain embodiments, isobutanol pathways utilizing reverse TCA and/or reducing equivalents from CO and/or hydrogen are used to enhance product yields. The organisms provided herein can be cultured to produce isopropanol, n-butanol, or isobutanol.

    Abstract translation: 本文提供了具有异丙醇途径并且包含至少一种编码异丙醇途径酶的外源核酸的非天然存在的微生物生物。 在某些实施方案中，该途径包括选自4-羟基丁酰-CoA脱水酶，巴豆酸酶，3-羟基丁酰辅酶A脱氢酶，乙酰乙酰辅酶A合成酶，乙酰辅酶A：乙酰乙酸酯-CoA转移酶，乙酰乙酰辅酶A 水解酶，乙酰乙酸脱羧酶和丙酮还原酶。 本文还提供了具有正丁醇途径的非天然存在的微生物生物，并且包含至少一种编码正丁醇途径酶的外源核酸。 本文还提供了其它具有正丁醇或异丁醇途径的非天然存在的微生物。 在某些实施方案中，使用利用反向TCA和/或来自CO和/或氢的还原当量的异丁醇途径来提高产物产率。 本文提供的生物体可以培养以产生异丙醇，正丁醇或异丁醇。

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