公开(公告)号：DE2557397A1

公开(公告)日：1976-06-24

申请号：DE2557397

申请日：1975-12-19

Applicant: GLAXO LAB LTD

Inventor： BRADSHAW JANICE ,  COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN ,  BEELS CHRISTOPHER DONALD

IPC: A61K31/545 ,  C07C20060101 ,  C07D20060101 ,  C07D501/04 ,  C07D501/44 ,  C07D501/46 ,  C07D501/60

公开(公告)号：DE2536337A1

公开(公告)日：1976-02-26

申请号：DE2536337

申请日：1975-08-14

Applicant: GLAXO LAB LTD

Inventor： COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN ,  BRADSHAW JANICE

IPC: A61K20060101 ,  A61K31/545 ,  C07D20060101 ,  C07D501/06 ,  C07D501/20 ,  C07D501/26 ,  C07D501/34 ,  C07D501/60

Abstract: Cephalosporin antibiotics in which the 7.beta.-acylamido group is syn 2-furyl-2-methoxyiminoacetamido and in which the 3-position substituent is a chloroalkylcarbamoyloxymethyl group exhibit high antibacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms, and stability in vivo. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer.

公开(公告)号：AU4229872A

公开(公告)日：1974-01-03

申请号：AU4229872

申请日：1972-05-15

Applicant: GLAXO LAB LTD

Inventor： COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN ,  BRADSHAW JANICE

IPC: C07C271/14 ,  C07D213/55 ,  C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D307/81 ,  C07D333/16 ,  C07D333/24 ,  C07D333/60 ,  C07D499/00 ,  C07D499/64 ,  C07C119/00 ,  A61K21/00 ,  C07D99/16

公开(公告)号：AU3696071A

公开(公告)日：1973-06-21

申请号：AU3696071

申请日：1971-12-16

Applicant: GLAXO LAB LTD

Inventor： PHILLIPPS GORDON HANLEY ,  NEWALL CHRISTOPHER EARLE ,  COOK MARTIN CHRISTOPHER

IPC: A61K20060101 ,  C07C20060101 ,  C07C167/00 ,  C07C169/00 ,  A61K17/00

Abstract: Steroids of the 5 alpha -pregnane series possessing a 3 alpha -hydroxy group, a 10-hydrogen atom or methyl group, an 11-oxo group, a 17 alpha -hydrogen atom, a 20-oxo group, and a group of the formula -XR at the 21-position wherein -XR represents -OCOR, -OCOOR, -CCOSR or -OCONHR and R represents (a) a solubilising group containing a basic nitrogen atom, (b) a nitrobenzyl group (c) a lower alkyl group (when X is not -OCO-) or (d) a halogenoalkyl group.

公开(公告)号：DK133682B

公开(公告)日：1976-06-28

申请号：DK614771

申请日：1971-12-16

Applicant: GLAXO LAB LTD

Inventor： COOK MARTIN CHRISTOPHER ,  LAWRENCE ROBIN ,  PHILLIPPS GORDON HANLEY ,  HUNTER ANNE CHRISTINE ,  NEWALL CHRISTOPHER EARLE ,  STEPHENSON LESLIE ,  WEIR NIALL GALBRAITH

IPC: A61K31/568 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  C07J1/00 ,  C07J3/00 ,  C07J17/00 ,  C07J41/00 ,  C07J43/00 ,  C07J75/00 ,  C07J7/00

公开(公告)号：AU6177873A

公开(公告)日：1975-04-24

申请号：AU6177873

申请日：1973-10-04

Applicant: GLAXO LAB LTD

Inventor： COOK MARTIN CHRISTOPHER ,  BRADSHAW JANICE ,  GREGORY GORDON IAN

IPC: C07D209/48 ,  C07D307/54 ,  C07D333/24 ,  C07D499/64 ,  C07D499/70 ,  C07D99/16 ,  A61K27/00 ,  C07C131/00

公开(公告)号：DE2065513A1

公开(公告)日：1974-04-04

申请号：DE2065513

申请日：1970-06-19

Applicant: GLAXO LAB LTD

Inventor： DAVIS BENJAMIN ,  PEARCE DERKEK ROGER ,  COOK MARTIN CHRISTOPHER ,  WEIR NIALL GALBRAITH ,  NEWALL CHRISTOPHER EARLE ,  AYRES BARRY EDWARD ,  GREGORY GORDON IAN ,  PHILLIPPS GORDON HANLEY

IPC: A61K9/08 ,  A61K31/16 ,  A61K31/57 ,  A61K31/573 ,  C07J5/00 ,  C07J7/00 ,  A61K27/00

Abstract: 1317184 Injectable anaesthetics GLAXO LABORATORIES Ltd 11 June 1970 [20 June 1969] 31371/69 Heading A5B [Also in Division C2] Anaesthetic compositions suitable for use by parenteral administration comprise an aqueous solution containing at least 1mg/ml of 3α- hydroxy-5α-pregnane-11, 20-dione and a non- ionic surface-active agent serving to solubilize the steroid. Preferably they contain at least 1% by weight of the agent and this has an HLB value of 9-18. Suitable agents include polyoxyethylated derivatives of fatty glyceride oils, polyoxyethylene ethers of long-chain alcohols, polyoxyethylene - polyoxypropylene ethers, polyoxyethylene ethers of alkyl phenols, polyoxyethylated fatty acid esters of sugar alcohol anhydrides, long-chain alkanoyl mono- and di-alkanolamides and polyethylene glycol esters of long-chain fatty acids. The solubility of the anaesthetic steroid may be further increased by addition of a steroid of the formula: wherein R is an optionally substituted alkanoyl, aroyl or aralkanoyl group. These steroids are described and claimed in Specification 1317185. They also possess some anaesthetic activity.

公开(公告)号：AU4229972A

公开(公告)日：1973-12-20

申请号：AU4229972

申请日：1972-05-15

Applicant: GLAXO LAB LTD

Inventor： COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN ,  BRADSHAW JANICE

IPC: C07C271/14 ,  C07D213/55 ,  C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D307/81 ,  C07D333/16 ,  C07D333/24 ,  C07D333/60 ,  C07D499/00 ,  C07D499/64 ,  C07D99/24 ,  A61K27/00 ,  A61K27/12 ,  C07C119/00 ,  C07C125/06

公开(公告)号：AU3845172A

公开(公告)日：1973-09-06

申请号：AU3845172

申请日：1972-01-28

Applicant: GLAXO LAB LTD

Inventor： GREGSON MICHAEL ,  COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN

IPC: C07D99/16 ,  A61K21/00 ,  C07C119/00 ,  C07D99/24

公开(公告)号：DK155187B

公开(公告)日：1989-02-27

申请号：DK237372

申请日：1972-05-12

Applicant: GLAXO LAB LTD

Inventor： COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN ,  BRADSHAW JANICE

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C251/32 ,  C07C271/14 ,  C07D213/55 ,  C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D307/81 ,  C07D333/16 ,  C07D333/24 ,  C07D333/32 ,  C07D333/60 ,  C07D409/12 ,  C07D499/00 ,  C07D501/20 ,  C07D501/32 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46