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公开(公告)号：US3883569A
公开(公告)日：1975-05-13
申请号：US20898571
申请日：1971-12-16
Applicant: GLAXO LAB LTD
IPC: A61K20060101 , C07C20060101 , C07C169/32
CPC classification number: C07J5/00
Abstract: Steroids of the 5 Alpha -pregnane series possessing a 3 Alpha hydroxy group, a 10-hydrogen atom or methyl group, an 11-oxo group, a 17 Alpha -hydrogen atom, a 20-oxo group, and a group of the formula -XR at the 21-position wherein -XR represents -OCOR, -OCOOR, -CCOSR or -OCONHR and R represents (a) a solubilising group containing a basic nitrogen atom, (b) a nitrobenzyl group (c) a lower alkyl group (when X is not -OCO-) or (d) a halogenoalkyl group. The steroids possess anaesthetic properties.
Abstract translation: 具有3α-羟基，10-氢原子或甲基，11-氧代基，17α-氢原子，20-氧代基和式 - 基团的5α-孕烷系的类固醇 -XR为21位，其中-XR表示-OCOR，-OCOOR，-CCOSR或-OCONHR，R表示（a）含有碱性氮原子的增溶基团，（b）硝基苄基（c）低级烷基 （当X不为-OCO-）或（d）卤代烷基时。
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公开(公告)号：US3882151A
公开(公告)日：1975-05-06
申请号：US20896171
申请日：1971-12-16
Applicant: GLAXO LAB LTD
Inventor： PHILLIPPS GORDON HANLEY , NEWALL CHRISTOPHER EARLE
IPC: A61K38/00 , C07C167/00
CPC classification number: A61K38/00 , C07J5/0015 , C07J5/003 , C07J7/003 , C07J7/0085 , C07J17/00 , C07J41/0038 , C07J41/005 , C07J41/0094 , C07J43/003 , Y02P20/55 , Y10S514/816
Abstract: The invention provides 3 Alpha -oxygenated pregnane 21-ethers possessing a hydroxy group in the 3 Alpha -position; a hydrogen atom or a methyl group at the 10-position; a hydrogen atom in the 17 Alpha -position; a keto group in the 20-position; and an etherified hydroxyl group in the 21-position.
Abstract translation: 本发明提供了3个α位具有羟基的3个α-氧化孕烷21-醚; 10位的氢原子或甲基; 17个α位的氢原子; 二十位酮基组; 和21位的醚化羟基。
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公开(公告)号：US3869451A
公开(公告)日：1975-03-04
申请号：US19791571
申请日：1971-11-11
Applicant: GLAXO LAB LTD
IPC: C07J7/00 , C07C169/32
CPC classification number: C07J7/00 , Y10S514/816
Abstract: This invention relates to steroids of the pregnane and 19norpregnane series having anaesthetic properties and compositions containing them. More particularly the present invention relates to such steroids having a variety of substituents in the 2 Beta position, a 3 Alpha -hydroxy group and a 5 Alpha -hydrogen atom and esters and 20-ketals thereof. At the 11-position of such steriods is preferably either two hydrogen atoms or an oxo group. The compounds according to the invention may conveniently be prepared by reaction of an appropriate 2 Alpha ,3 Alpha -epoxypregnane or 19-norpregnane with a reagent which introduces the desired 2 Beta -substituent and various modifications of the compound produced are described to produce compounds within the scope of the invention. The present invention provides compositions containing certain steroids of the pregnane and 19norpregnane series and such compositions generally may be administered intravenously to induce anaesthesia, the invention providing methods of inducing anaesthesia.
Abstract translation: 本发明涉及具有麻醉性质的孕烷和19-去戊孕烷系列的类固醇和含有它们的组合物。 更具体地说，本发明涉及在2β-位具有多种取代基的这种类固醇，3α-羟基和5α-氢原子以及其酯和20缩酮。 这种类固醇的11位优选为两个氢原子或氧代基团。 根据本发明的化合物可以方便地通过使合适的2α，3α-环氧孕烷或19-去甲孕烷与引入所需的2β-取代基的试剂反应制备，并且所述化合物的各种修饰被描述为产生 化合物在本发明的范围内。 本发明提供含有孕甾烷酮和19-去甲孕烷系列的某些类固醇的组合物，并且这些组合物通常可以静脉内施用以诱导麻醉，本发明提供诱导麻醉的方法。
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公开(公告)号：CH616691A5
公开(公告)日：1980-04-15
申请号：CH1837071
申请日：1971-12-16
Applicant: GLAXO LAB LTD
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公开(公告)号：DK134996B
公开(公告)日：1977-02-21
申请号：DK642071
申请日：1971-12-29
Applicant: GLAXO LAB LTD
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Patent Agency Ranking
公开(公告)号：ZA717587B
公开(公告)日：1973-06-27
申请号：ZA717587
申请日：1971-11-11
Applicant: GLAXO LAB LTD
Abstract: This invention relates to steroids of the pregnane and 19-norpregnane series having anaesthetic properties and compositions containing them. More particularly the present invention relates to such steroids having a variety of substituents in the 2 beta -position, a 3 alpha -hydroxy group and a 5 alpha -hydrogen atom and esters and 20-ketals thereof. At the 11-position of such steriods is preferably either two hydrogen atoms or an oxo group. The compounds according to the invention may conveniently be prepared by reaction of an appropriate 2 alpha ,3 alpha -epoxy-pregnane or 19-norpregnane with a reagent which introduces the desired 2 beta -substituent and various modifications of the compound produced are described to produce compounds within the scope of the invention. The present invention provides compositions containing certain steroids of the pregnane and 19-norpregnane series and such compositions generally may be administered intravenously to induce anaesthesia, the invention providing methods of inducing anaesthesia.
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公开(公告)号：ZA7107587B
公开(公告)日：1973-06-27
申请号：ZA7107587
申请日：1971-11-11
Applicant: GLAXO LAB LTD
CPC classification number: C07J7/00 , Y10S514/816
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公开(公告)号：AU2644177A
公开(公告)日：1979-01-04
申请号：AU2644177
申请日：1977-06-24
Applicant: GLAXO LAB LTD
Inventor： CHERRY PETER CLIVE , NEWALL CHRISTOPHER EARLE , WATSON NIGEL STEPHEN , GREGORY GORDON IAN , WARD PETER
IPC: C07D503/00 , C07D498/04
Abstract: 2-Vinylclavem compounds are disclosed which have been found of value in the synthesis of thio-derivatives of clavulanic acid which possess antibiotic and beta -lactamase inhibitory activity. Methods for preparing the vinylclavem compounds are disclosed and processes for preparing the thio-derivatives are given.
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公开(公告)号：DE2747599A1
公开(公告)日：1978-04-27
申请号：DE2747599
申请日：1977-10-24
Applicant: GLAXO LAB LTD
Inventor： CHERRY PETER CLIVE , NEWALL CHRISTOPHER EARLE , TONGE ALAN PAUL
IPC: A61K31/42 , A61K31/455 , A61K31/655 , A61P43/00 , C07D503/00 , C07D498/04
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公开(公告)号：DE2740526A1
公开(公告)日：1978-03-16
申请号：DE2740526
申请日：1977-09-08
Applicant: GLAXO LAB LTD
IPC: A61K31/42 , A61P31/04 , C07D205/08 , C07D503/00 , C07F7/18 , C07D498/00
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