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    Novel 3{60 -hydroxysteroids of the 5{60 -pregnane series
    2.
    发明授权
    Novel 3{60 -hydroxysteroids of the 5{60 -pregnane series 失效
    5 {60-孕烷系列的新型3 {60-羟基类固醇

    公开(公告)号：US3883569A

    公开(公告)日：1975-05-13

    申请号：US20898571

    申请日：1971-12-16

    Applicant: GLAXO LAB LTD

    Inventor： PHILLIPPS GORDON HANLEY ,  NEWALL CHRISTOPHER EARLE ,  COOK MARTIN CHRISTOPHER

    IPC: A61K20060101 ,  C07C20060101 ,  C07C169/32

    CPC classification number: C07J5/00

    Abstract: Steroids of the 5 Alpha -pregnane series possessing a 3 Alpha hydroxy group, a 10-hydrogen atom or methyl group, an 11-oxo group, a 17 Alpha -hydrogen atom, a 20-oxo group, and a group of the formula -XR at the 21-position wherein -XR represents -OCOR, -OCOOR, -CCOSR or -OCONHR and R represents (a) a solubilising group containing a basic nitrogen atom, (b) a nitrobenzyl group (c) a lower alkyl group (when X is not -OCO-) or (d) a halogenoalkyl group. The steroids possess anaesthetic properties.

    Abstract translation: 具有3α-羟基，10-氢原子或甲基，11-氧代基，17α-氢原子，20-氧代基和式 - 基团的5α-孕烷系的类固醇 -XR为21位，其中-XR表示-OCOR，-OCOOR，-CCOSR或-OCONHR，R表示（a）含有碱性氮原子的增溶基团，（b）硝基苄基（c）低级烷基 （当X不为-OCO-）或（d）卤代烷基时。

    Penicillin antibiotics
    3.
    发明授权
    Penicillin antibiotics 失效

    公开(公告)号：US3926957A

    公开(公告)日：1975-12-16

    申请号：US46678074

    申请日：1974-05-03

    Applicant: GLAXO LAB LTD

    Inventor： GREGSON MICHAEL ,  COOK MARTIN CHRISTOPHER ,  GREGORY GORDON IAN

    IPC: C07C259/02 ,  C07D307/54 ,  C07D333/24 ,  C07D499/70 ,  C07D499/44

    CPC classification number: C07D307/54 ,  C07C259/02 ,  C07D333/24

    Abstract: WHERE R is a hydrogen atom or an organic group and Ra is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to Beta -lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

    The invention provides novel antibiotic compounds which are 6 Beta -acylamidopenam-3-carboxylic acids and non-toxic derivatives thereof, characterized in that the acylamido group has the structure

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