公开(公告)号：HU221856B1

公开(公告)日：2003-02-28

申请号：HU9702260

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： JOHNSON KEITH ARTHUR ,  LI-BOVET LI

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：MD1900C2

公开(公告)日：2002-12-31

申请号：MD970134

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  C07F9/10 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C09K23/20

Abstract: Este revendicată o compoziţie farmaceutică de aerosol, ce conţine medicament pulverulent, propelent de fluorură de carbon sau clorfluorură de carbon cu conţinut de hidrogen şi substanţă tensioactivă cu formula generală (I):în care n reprezintă un număr întreg cuprins între 1 … 18;m reprezintă un număr întreg cuprins între 0 …17;R1, R2 şi R3 fiecare independent reprezintă un atom de hidrogen sau o grupă C1-4alchil.De asemenea este revendicată o metodă de tratament al afecţiunilor respiratorii cu ajutorul acestei compoziţii farmaceutice.

公开(公告)号：RU2157188C2

公开(公告)日：2000-10-10

申请号：RU97106511

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  A61K9/12 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: pharmaceutical chemistry. SUBSTANCE: pharmaceutical composition contains powdered medicament, fluorocarbon or hydrogen-containing chlorofluorocarbon propellant, and surfactant of general formula 1a: R1-CH2-CHR2-CH2-OP(=O)XY (1a), 1b: (R1-CH2)2CH-OP(=O)XY (1b), and 1: (1), where R1, R2, R3 are indicated in claims. EFFECT: invention provides fixed unit dose for medicaments depending on severity of disease. 18 cl, 73 ex

公开(公告)号：DK0783302T3

公开(公告)日：2000-05-29

申请号：DK95932166

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：NZ306278A

公开(公告)日：1999-07-29

申请号：NZ30627896

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14 ,  B65D83/38 ,  A61K31/165

Abstract: Metered dose inhaler having all or part of its internal surfaces coated with one or more fluorocarbon polymers, opt. in combination with one or more non-fluorocarbon polymers, is used for dispensing an inhalation drug formulation comprising albuterol (also known as salbutamol) or one of its salts, and a fluorocarbon propellant, opt. in combination with one or more other pharmacologically active agents or one or more excipients. Also claimed is a metered dose inhaler system comprising a metered dose inhaler fitted into a suitable channelling device for oral or nasal inhalation of the drug formulation.

公开(公告)号：CZ9703261A3

公开(公告)日：1999-06-16

申请号：CZ326197

申请日：1996-04-11

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14

CPC classification number: A61K9/008 ,  A61K31/573 ,  A61M15/009 ,  A61M2205/0222 ,  B65D83/54 ,  B65D83/752

公开(公告)号：AP742A

公开(公告)日：1999-04-26

申请号：AP9700951

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20 ,  A61K9/27

Abstract: A pharmaceutical aerosol formulation which comprises particuiate medicament, a fluorocarbon or hydrogen-containing chlorofiuorocarbon propellant and a surfactant of general formula (I) O CnF2n+1(CH2)m-C-0-CH2 0 CnF2n+1(CH2)m-C-0-CH O il © R CH,-0-P-0-CH,CH,N-R 0 R wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a Chalky! group.

公开(公告)号：BR9509108A

公开(公告)日：1998-07-14

申请号：BR9509108

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：BR9604977A

公开(公告)日：1998-06-09

申请号：BR9604977

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  RIEBE MICHAEL T ,  LI-BOVET LI

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14

Abstract: A metered dose inhaler characterised in that part or all of its internal surfaces are coated with a polymer blend of one or more fluorocarbon polymers in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients, wherein a) the fluorocarbon polymer is selected from the group consisting of PTFE, PFA, FEP and mixtures thereof, b) the non-fluorocarbon polymer is selected from the group consisting of polyamideimides, polyimides, polyethersulfones, polyphenylene sulfides and amine-formaldehyde thermosetting resins, (c) the inhaler comprises a can made of metal whose interior surfaces are coated with the polymer blend.

公开(公告)号：TR9701169T1

公开(公告)日：1998-03-21

申请号：TR9701169

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL THOMAS

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14

CPC classification number: B65D83/54 ,  A61M15/009 ,  A61M2205/0222 ,  A61M2205/0233