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    BIOMETRIC APPARATUS AND IMAGE-GENERATING METHOD
    22.
    发明公开
    BIOMETRIC APPARATUS AND IMAGE-GENERATING METHOD 有权
    生物识别设备和成像及其方法

    公开(公告)号：EP2730231A4

    公开(公告)日：2015-03-25

    申请号：EP12807701

    申请日：2012-06-28

    Applicant: HAMAMATSU PHOTONICS KK

    Inventor： KUDO HIROYUKI ,  SAITO NAOYA ,  UEDA YUKIO ,  YOSHIMOTO KENJI ,  YAMASHITA YUTAKA

    IPC: A61B5/00 ,  A61B6/00 ,  A61B6/03 ,  A61B8/15 ,  A61B10/00 ,  G01N21/17 ,  G01N21/47 ,  G06T11/00

    CPC classification number: A61B5/7203 ,  A61B5/0073 ,  A61B5/0082 ,  A61B6/5247 ,  A61B8/15 ,  A61B8/5207 ,  A61B10/0041 ,  G01N21/4795 ,  G06T11/006

    Abstract: The bioinstrumentation apparatus 10 includes a light irradiation unit irradiating a measurement region B with light, a light detection unit detecting diffused light from the measurement region, and a computing unit 14 generating a reconstructed image for the interior of the measurement region. The computing unit 14 calculates J coefficients w j set for every pixel of the reconstructed image and more than 0 and not more than 1 (where J is the number of pixels of the reconstructed image) and carries out successive approximation computation by the following iterative formula x j k + 1 = x j k + w j �¢ d j k (where k is an integer from 1 to N, N is the number of times of iterative computation, x j (k) is a pixel value of the jth pixel on the kth iterative computation, and d j (k) is an update amount of the jth pixel on the kth iterative computation) to generate the reconstructed image. Thereby, there are provided a bioinstrumentation apparatus and an image generating method capable of suppressing a difference in spatial resolution and noise characteristics depending on a position inside the measurement region to generate an image which is uniform to a greater extent.

    Method for assessing vascular permeability sthenia inhibitory effect
    25.
    发明专利
    Method for assessing vascular permeability sthenia inhibitory effect 有权
    评估血管渗透性STHENIA抑制作用的方法

    公开(公告)号：JP2014161270A

    公开(公告)日：2014-09-08

    申请号：JP2013034570

    申请日：2013-02-25

    Applicant: Hamamatsu Univ School Of Medicine ,  国立大学法人浜松医科大学 ,  Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

    Inventor： YAMAUCHI TOYOHIKO ,  HIRAKAWA SATOSHI ,  YAMASHITA YUTAKA ,  TOKURA YOSHIKI

    IPC: C12Q1/02

    CPC classification number: G01N33/5026 ,  G01N33/5064

    Abstract: PROBLEM TO BE SOLVED: To provide a method for assessing vascular permeability sthenia inhibitory effect in vascular endothelial cells of test substance.SOLUTION: A method comprises a process for contacting a test substance to a vascular endothelial cell, a process for contacting an agent which increases vascular permeability of the vascular endothelial cell to a vascular endothelial cell, and a process for measuring a top height of the vascular endothelial cell, wherein the top height of the vascular endothelial cell is an index of vascular permeability sthenia inhibitory effect of the vascular endothelial cell in the test substance.

    Abstract translation: 要解决的问题：提供一种用于评估测试物质的血管内皮细胞中血管通透性降低抑制作用的方法。解决方案：一种方法包括使测试物质与血管内皮细胞接触的方法， 血管内皮细胞对血管内皮细胞的血管通透性，以及测定血管内皮细胞顶部高度的方法，其中血管内皮细胞的顶部高度是血管内皮细胞血管通透性降低抑制作用的指标 在测试物质中。

    Mammographic apparatus
    26.
    发明专利
    Mammographic apparatus 有权
    家庭装置

    公开(公告)号：JP2008099810A

    公开(公告)日：2008-05-01

    申请号：JP2006283940

    申请日：2006-10-18

    Applicant: Hamamatsu Photonics Kk ,  浜松ホトニクス株式会社

    Inventor： YAMASHITA DAISUKE ,  SUZUKI TOSHIHIKO ,  YAMASHITA YUTAKA

    IPC: A61B10/00

    Abstract: PROBLEM TO BE SOLVED: To stabilize the flow of an interface agent inside a vessel in a mammographic apparatus of such a type that the interface agent is circulated inside/outside of the vessel.
    SOLUTION: The mammographic apparatus 1 obtains the information on the inside of a breast by irradiating the breast of a subject with light and detecting the diffused light. The mammographic apparatus 1 comprises an inner vessel 31 surrounding the hanging breast; an outer vessel 32 constituting a gap 34 with the inner vessel 31; a partition wall 33 dividing the gap 34 into an inflow chamber 35 and an outflow chamber 36; piping 13e for injecting the interface agent I into the inflow chamber 35; and piping 13a for discharging the interface agent I from the outflow chamber 36. The inner vessel 31 has an interface agent inlet 14 for letting the interface agent I in the inflow chamber 35 flow into the inner vessel 31 and an interface agent outlet 15 for letting the interface agent I in the inner vessel 31 flow into the outflow chamber 36.
    COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：为了使界面剂在容器内部/外部循环的乳腺摄影装置中的容器内的界面剂的流动稳定。 解决方案：乳房X光照相设备1通过用光照射对象的乳房并检测漫射光来获得乳房内部的信息。 乳房X线摄影装置1包括围绕悬挂乳房的内容器31; 与内部容器31构成间隙34的外部容器32; 分隔壁33将间隙34分成流入室35和流出室36; 用于将界面剂I注入流入室35的管道13e; 以及用于从流出室36排出界面剂I的管道13a。内容器31具有用于使流入室35中的界面剂I流入内容器31的界面剂入口14和用于放出的界面剂出口15 内容器31中的界面剂I流入流出室36.版权所有（C）2008，JPO＆INPIT

    METHOD AND APPARATUS FOR INSPECTING SERUM PROTEIN
    27.
    发明专利
    METHOD AND APPARATUS FOR INSPECTING SERUM PROTEIN 失效

    公开(公告)号：JPH11108924A

    公开(公告)日：1999-04-23

    申请号：JP26990597

    申请日：1997-10-02

    Applicant: HAMAMATSU PHOTONICS KK

    Inventor： ARAKI RYUICHIRO ,  YAMASHITA YUTAKA

    IPC: G01N21/64 ,  G01N33/49 ,  G01N33/52 ,  G01N33/68

    Abstract: PROBLEM TO BE SOLVED: To simply and rapidly measure the constitutional ratio of serum protein. SOLUTION: Serum to which 0.5 μg/ml of indocyanine green(ICG) is added is housed in a test tube 2 as a measuring sample 1 to be irradiated with pulse laser with a wavelength of 790 nm from an exciting light irradiation means 3. ICG mainly bonded to lipoprotein in serum emits fluorescence of a fluorescence life profile corresponding to the constitutional ratio of lipoprotein. This fluorescence is guided to a fluorescence detector 5 through a spectral means 4 and fluorescence life is calculated to be sent to an analyser 6. The analyser 6 calculates the constitutional ratio of lipoprotein from the calculated fluorescence life to display the same on a display device 7. By this constitution, the constitutional ratio of liporotein can be accurately inspected simply within a short time as compared with a conventional method.

    OPTICAL CT DEVICE AN IMAGE RECONSTRUCTING METHOD
    28.
    发明专利
    OPTICAL CT DEVICE AN IMAGE RECONSTRUCTING METHOD 失效

    公开(公告)号：JPH10318911A

    公开(公告)日：1998-12-04

    申请号：JP13243597

    申请日：1997-05-22

    Applicant: HAMAMATSU PHOTONICS KK

    Inventor： OTA KAZUYOSHI ,  YAMASHITA YUTAKA

    IPC: G01N21/17 ,  A61B10/00

    Abstract: PROBLEM TO BE SOLVED: To enable the calculation of the accurate absorption coefficient of a sample regardless of the largeness or smallness of the absorption coefficient. SOLUTION: This device is provided with light source 21 which emits light to a light projection part, a light projecting side optical switch 22 with one input and n (n is natural number) outputs, and n pieces of optical fibers F1 to Fn. A light receiving part is provided with m (m is a natural number) pieces of optical fibers B1 to Bm, a light receiving side optical switch 32 with m inputs and one output, and a light detecting part 31. Here, the light projecting side optical switch 22 and the light receiving side optical switch 32 are switched by a control part 11 to project and to receive light selectively through each optical fiber. From the observed value of the intensity of transmitted light observed by the detecting part 31 and stored in a storage part 13 and from the length distribution of the light path of each volume element calculated by Monte Carlo method, the distribution image of the absorption coefficient of a body to be tested 40 is calculated and displayed at a display part 14.

    OPTICAL MEASURING METHOD AND OPTICAL MEASURING DEVICE
    29.
    发明专利
    OPTICAL MEASURING METHOD AND OPTICAL MEASURING DEVICE 失效

    公开(公告)号：JPH0961343A

    公开(公告)日：1997-03-07

    申请号：JP21851095

    申请日：1995-08-28

    Applicant: HAMAMATSU PHOTONICS KK

    Inventor： URAGAMI TSUNEYUKI ,  MIWA MITSUHARU ,  YAMASHITA YUTAKA ,  TSUCHIYA YUTAKA

    IPC: G01N21/27 ,  A61B5/00 ,  G01J1/42

    Abstract: PROBLEM TO BE SOLVED: To provide an optical measuring method and an optical measuring device capable of determining the true center of gravity of a light wave-form and acquiring the internal information of a measured object in a short time. SOLUTION: This optical measuring device is provided with a light source 10 outputting a probe light, light guiding means 12, 14, a light detecting means 16, center of gravity calculation sections 18, 20, and a difference calculation section 30. The difference calculation section 30 subtracts the center of gravity of the device function from the center of gravity of the observed wave-form, thus the true center of gravity of the probe light wave-form is simply determined, and a desired optical measurement can be conducted in a short time.

    COMPOSITION FOR SELECTIVELY TREATING TUMOR
    30.
    发明专利
    COMPOSITION FOR SELECTIVELY TREATING TUMOR 失效

    公开(公告)号：JPS63243025A

    公开(公告)日：1988-10-07

    申请号：JP7706987

    申请日：1987-03-30

    Applicant: HAMAMATSU PHOTONICS KK

    Inventor： NAKAMURA TATSU ,  YAMASHITA YUTAKA ,  OTA KAZUYOSHI ,  FUJIWAKE HIDEJI

    IPC: A61K31/23 ,  A61K31/40 ,  A61K31/555 ,  A61K41/00 ,  A61K45/00 ,  A61K45/06 ,  A61P35/00

    Abstract: PURPOSE:To obtain the titled composition, capable of being selectively incorporated into tumorous cells and exhibiting cellulicidal effects of a photosensitive substance by subsequent irradiation with light, by blending an oily contrast medium with the photosensitive substance soluble therein. CONSTITUTION:A composition obtained by blending an oily contrast medium, preferably iodinated poppy seed oil fatty acid ester (particularly lipiodol which is ethyl ester) with a photosensive substance soluble therein, preferably a photosensitive substance excited by rays having high tissue penetrability (particularly rays at >=650nm wavelength), e.g. pheophorobide a or phthalocyanine derivative. The above-mentioned composition is administered and rays, preferably laser beams are irradiated after 6-24hr to excite the photosensitive substance and activate oxygen molecules. Thereby active oxygen is induced to exhibit cellulicidal effects on tumorous cells.

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