公开(公告)号：SE7411156L

公开(公告)日：1975-03-07

申请号：SE7411156

申请日：1974-09-04

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMANN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D9/00

Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.