公开(公告)号：AU507003B2

公开(公告)日：1980-01-31

申请号：AU2578377

申请日：1977-06-02

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  HELSLEY G C

IPC: A61K31/335 ,  A61P29/00 ,  C07D313/12

Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.

公开(公告)号：DK243777A

公开(公告)日：1977-12-04

申请号：DK243777

申请日：1977-06-02

Applicant: HOECHST AG

Inventor： MC FADDEN A R ,  HELSLEY G C

IPC: A61K31/335 ,  A61P29/00 ,  C07D313/12 ,  C07D

Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.

公开(公告)号：DK470574A

公开(公告)日：1975-05-05

申请号：DK470574

申请日：1974-09-05

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMANN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12

Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

公开(公告)号：DK143700B

公开(公告)日：1981-09-28

申请号：DK106877

申请日：1977-03-11

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  GARDNER B A ,  STRUPCZEWSKI J T

IPC: C07D20060101 ,  C07D401/06

公开(公告)号：NO743203A

公开(公告)日：1975-04-01

申请号：NO743203

申请日：1974-09-05

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMANN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D

CPC classification number: C07D313/12 ,  C07C59/70 ,  C07C65/24

公开(公告)号：SE7411156L

公开(公告)日：1975-03-07

申请号：SE7411156

申请日：1974-09-04

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMANN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D9/00

Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

公开(公告)号：DK143700C

公开(公告)日：1982-03-15

申请号：DK106877

申请日：1977-03-11

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  GARDNER B A ,  STRUPCZEWSKI J T

IPC: C07D20060101 ,  C07D401/06

公开(公告)号：DK106877A

公开(公告)日：1978-09-12

申请号：DK106877

申请日：1977-03-11

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  GARDNER B A ,  STRUPEZEWSKI J T

IPC: C07D20060101 ,  C07D401/06 ,  C07D

公开(公告)号：AU499709B2

公开(公告)日：1979-05-03

申请号：AU7296274

申请日：1974-09-04

Applicant: HOECHST AG

Inventor： HELSLEY G C ,  MCFADDEN A R ,  HOFFMAN D

IPC: C07C59/70 ,  C07C65/24 ,  C07D313/12 ,  C07D9/00 ,  A61K27/00

Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.

公开(公告)号：SE7706527L

公开(公告)日：1977-12-04

申请号：SE7706527

申请日：1977-06-03

Applicant: HOECHST AG

Inventor： MCFADDEN A R ,  HELSLEY G C

IPC: A61K31/335 ,  A61P29/00 ,  C07D313/12

Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.