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1.发明授权
公开(公告)号：KR790001066B1
公开(公告)日：1979-08-24
申请号：KR750002624
申请日：1975-12-01
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
Abstract: Title compd. (I; R = H or C1-4 alkyl, R1 = H, halogen, C1-4 alkoxy, C1-14 alkyl or acidic fluoromethyl, n = 1-3) and its ester, having good antiinflammatory activity, was prepd. Thus, alkyl ester (II) and hydroxypheny lacetic alkyl ester (III) was reacted to obtain diester(IV) in the presence of solvent or acid acceptor at 0-120≦̸C for 5min-20hr, and saponificated, cyclized, or reacted with thionyl halide and phosphorous halide to make 2-acid halide, the reaction product was cyclized by heating at 80-120≦̸C, and hydrolyzed, to giveI.
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公开(公告)号：KR790001067B1
公开(公告)日：1979-08-24
申请号：KR750002751
申请日：1975-12-16
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
Abstract: Title compd., useful as analgesics and inflammation inhibitors(no data), was prepd. Thus, lower alkylester reacted with the lower alkylester of (hydroxy-phenyl) acetic acid to give Ia(X = pentagonal or hexagonal heteroaryl ring contg. 1 or 2 O, N, or S with C, R1 = H or methyl, R2 = H or methyl, n = 1,2,3) and II or III (Y=Br, Cl) was cyclized followed by hydrolysis to give Ib(R = H or C1-5 straighted or branched alkyl).
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公开(公告)号：AU520265B2
公开(公告)日：1982-01-21
申请号：AU4933879
申请日：1979-07-27
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
IPC: C07D207/34 , C07D213/80 , C07D307/68 , C07D333/38
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公开(公告)号：NO762929A
公开(公告)日：1977-03-01
申请号：NO762929
申请日：1976-08-25
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
IPC: C07D207/34 , C07D213/80 , C07D307/68 , C07D333/38 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D
CPC classification number: C07D213/80 , C07D207/34 , C07D307/68 , C07D333/38 , C07D491/04 , C07D493/04 , C07D495/04 , Y10S514/887
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公开(公告)号：NO762647A
公开(公告)日：1977-02-01
申请号：NO762647
申请日：1976-07-29
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
IPC: A61K31/55 , A61P25/04 , A61P29/00 , C07D313/12 , C07D
CPC classification number: C07D313/12
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Patent Agency Ranking
公开(公告)号：SE7411156L
公开(公告)日：1975-03-07
申请号：SE7411156
申请日：1974-09-04
Applicant: HOECHST AG
Inventor： HELSLEY G C , MCFADDEN A R , HOFFMANN D
IPC: C07C59/70 , C07C65/24 , C07D313/12 , C07D9/00
Abstract: 6,11-Dihydrodibenz[b,e]oxepin-acetic acids and derivatives having the general formula are prepared by multi-step sequences. X is C=O, CHCl, CHBr, CH2 or CHOR4; Y is alkyl or alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; n is 0, 1, 2 or 3; Z is COOR5, CH2OR5, CONR25 or CONHOR5; and R1-R5 are hydrogen or alkyl of 1 to 4 carbon atoms. These compounds and the physiologically tolerable salts thereof are useful as antiinflammatory and analgesic agents.
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公开(公告)号：AU507003B2
公开(公告)日：1980-01-31
申请号：AU2578377
申请日：1977-06-02
Applicant: HOECHST AG
Inventor： MCFADDEN A R , HELSLEY G C
IPC: A61K31/335 , A61P29/00 , C07D313/12
Abstract: Benzyl and related esters of 6,11-dihydrodibenz[b,e]oxepin-acetic and method for preparing same are described. These compounds are valuable as systemic and topical anti-inflammatory agents.
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公开(公告)号：AU504461B2
公开(公告)日：1979-10-18
申请号：AU1715176
申请日：1976-08-25
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
IPC: C07D207/34 , C07D213/80 , C07D307/68 , C07D333/38 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04 , C07D513/04 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/38 , A61K31/40 , A61K31/435 , C07D498/04
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公开(公告)号：SE7609390A
公开(公告)日：1977-02-27
申请号：SE7609390
申请日：1976-08-25
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
IPC: C07D207/34 , C07D213/80 , C07D307/68 , C07D333/38 , C07D491/04 , C07D491/044 , C07D493/04 , C07D495/04
CPC classification number: C07D213/80 , C07D207/34 , C07D307/68 , C07D333/38 , C07D491/04 , C07D493/04 , C07D495/04 , Y10S514/887
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公开(公告)号：DK342476A
公开(公告)日：1977-01-31
申请号：DK342476
申请日：1976-07-29
Applicant: HOECHST AG
Inventor： MCFADDEN A R , AULTZ D E
IPC: A61K31/55 , A61P25/04 , A61P29/00 , C07D313/12 , C07D
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