公开(公告)号：BRPI0921348A2

公开(公告)日：2019-09-24

申请号：BRPI0921348

申请日：2009-11-03

Applicant: HOFFMANN LA ROCHE

Inventor： ANJA LIMBERG ,  ERWIN GOETSCHI ,  KARLHEINZ BAUMANN ,  SYNESE JOLIDON ,  THOMAS LUEBBERS

IPC: C07D401/12 ,  A61K31/4178 ,  C07D413/12 ,  C07D417/12

公开(公告)号：CL2009000023A1

公开(公告)日：2010-05-07

申请号：CL2009000023

申请日：2009-01-08

Applicant: HOFFMANN LA ROCHE

Inventor： ERWIN GOETSCHI ,  SYNESE JOLIDON ,  HELMUT JACOBSEN ,  ALEXANDER FLOHR ,  KARLHEINZ BAUMANN ,  THOMAS LUEBBERS

IPC: A61K31/428 ,  A61P9/00 ,  A61P25/00 ,  A61P25/28 ,  C07D233/60 ,  C07D249/08 ,  C07D263/32 ,  C07D277/60 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/052

Abstract: Compuestos derivados de heterociclos de nitrógeno y azufre, moduladores de beta-amiloide; procedimiento de preparación; composición farmacéutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de Alzheimer, angiopatía amiloide cerebral, hemorragia cerebral, demencia multiinfarto, demencia pugilística o Síndrome de Down.

公开(公告)号：JO2495B

公开(公告)日：2009-10-05

申请号：JO20039

申请日：2003-02-02

Applicant: HOFFMANN LA ROCHE

Inventor： GEO ADAM ,  ERWIN GOETSCHI ,  JUERGEN WICHMANN ,  THOMAS JOHANNES WOLTERING

Abstract: The invention relates to dihydro-‎benzo[b][1,4] diazepin-2-one derivatives of ‎the general formula ‎ wherein R1, R2, X and Y are as defined in ‎the specification and R3 is a six-membered ‎aromatic heterocycle containing 1 to 3 ‎nitrogen atoms or a pyridine-N-oxide as ‎further defined in the specification. The ‎invention further relates to medicaments ‎containing these compounds, a process for ‎their preparation as well as their use for ‎preparation of medicaments for the ‎treatment or prevention of acute and/or ‎chronic neurological disorders.

公开(公告)号：ZA200610102B

公开(公告)日：2008-08-27

申请号：ZA200610102

申请日：2006-12-01

Applicant: HOFFMANN LA ROCHE

Inventor： ERWIN GOETSCHI ,  JOHANNES WOLTERING THOMAS ,  JUERGEN WICHMANN

IPC: A61K20090101 ,  A61P20090101 ,  C07D20090101 ,  C07D487/04

公开(公告)号：JO2285B

公开(公告)日：2005-09-12

申请号：JO200232

申请日：2002-04-10

Applicant: HOFFMANN LA ROCHE

Inventor： MUTEL VINCENT ,  WICHMANN JUERGEN ,  GEO ADAM ,  ERWIN GOETSCHI ,  THOMAS JOHANNES WOLTERING

IPC: C07D243/12 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/00 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14

CPC classification number: C07D401/04 ,  C07D403/10 ,  C07D403/14 ,  C07D417/10

Abstract: This invention is concerned with dihydro-benzo [b] [1,4] diazepin-2-one derivatives of the general formula: Wherein RI, R2, R3, X and Y are as defined in the specification. The invention further relates to med medicaments containing there compounds, a process for their preparations as well as their use for preparation of medicaments for the treatment for the treatment or prevention of acute and/or chronic neurological disorders

公开(公告)号：ZA885790B

公开(公告)日：1989-04-26

申请号：ZA885790

申请日：1988-08-05

Applicant: HOFFMANN LA ROCHE

Inventor： GOETSCHI ERWIN ,  ERWIN GOETSCHI

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K