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    N-Acylamino Benzyl Ether Derivatives
    8.
    发明专利
    N-Acylamino Benzyl Ether Derivatives 未知

    公开(公告)号：JO2541B

    公开(公告)日：2010-09-05

    申请号：JO200358

    申请日：2003-05-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： SYNESE JOLIDON ,  ROSA MARIA RODRIGUEZ SARMIENTO ,  ANDREW WILLIAM THOMAS ,  & X C;RENE WYLER

    Abstract: This invention relates to N-acylamino aryl derivatives of the general formula (I), wherein R is halogen, halogen-(C1-C6)-alkyl, cyano, C1-C6-alkoxy or halogen-(C1-C6)-alkoxy; R , R , R and R independently from each other are selected from the group consisting of hydrogen, (C1-C6)-alkyl, halogen, halogen-(C1-C6)-alkyl, hydroxy, C1-C6-alkoxy or -CHO; R is hydrogen or C1-C3-alkyl; R , R independently from each other are selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-alkoxy or -COO(C1-C6)alkyl; or R and R form together with the C-atom to which they are attach a C3-C7-cycloalkyl ring; R is -CO-NR R ; -COO(C1-C6)-alkyl, -CN, -NR2 or -NHC(O)R; R and R independently from each other are selected from the group consisting of hydrogen, C1-C6-alkyl, NH2 or hydroxy; R is hydrogen or C1-C6-alkyl; n is 0, 1, 2 or 3. X is -CHRO, -OCHR, -CH2S-, -SCH2-, -CH2CH2-, -CH=CH- or -C=C-; and to pharmaceutically active acid addition salts thereof. It has been found that the compounds of general formula (I) are selective monoamine oxidase B inhibitors and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B inhibitors, for example for the treatment of Alzheimer's disease or senile dementia.

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