公开(公告)号：ZA7307898B

公开(公告)日：1974-07-31

申请号：ZA7307898

申请日：1973-10-09

Applicant: HOFFMANN LA ROCHE

Inventor： GILLESSEN D ,  RUDINGER J ,  STUDER R

IPC: A61K38/00 ,  C07C323/60 ,  C07K1/113 ,  C07K7/16 ,  C07K14/575 ,  C07K14/58 ,  C07C

CPC classification number: C07K7/16 ,  A61K38/00 ,  C07C323/60

公开(公告)号：ZA7305680B

公开(公告)日：1974-07-31

申请号：ZA7305680

申请日：1973-08-20

Applicant: HOFFMANN LA ROCHE

Inventor： STUDER R ,  GILLESSEN D ,  RUDINGER J

IPC: A61K38/00 ,  C07K1/113 ,  C07K5/103 ,  C07K7/16 ,  C07K14/575 ,  C07K14/58 ,  C07C

CPC classification number: C07K7/16 ,  A61K38/00 ,  C07K5/1005

公开(公告)号：ZA733419B

公开(公告)日：1974-03-27

申请号：ZA733419

申请日：1973-05-21

Applicant: HOFFMANN LA ROCHE

Inventor： RUDINGER J ,  GILLESSEN D ,  STUDER R

IPC: A61K38/00 ,  C07K5/103 ,  C07K7/16 ,  C07C

Abstract: Cpds. of gen. formula (I): where Q = arginine or lysine residue; Mpr = beta-mercaptopropionyl; all amino acids with asymmetric C-atom have L-configuration; including pharmaceutically-acceptable, non-toxic acid-addn. salts of (I); are prepd. by e.g. removing protecting gps. of a cpd. (III): (where R1 = H or an amido-protecting gp. Q1 = NH-CH/-(CH2)3-NH-C(=NH-NHR2/-CO or -NH-CH/-(CH2)4-NHR3/-CO-; R2 = H or a guanidino-protecting gp; R3 = H or an -amino gp. of lysine-protecting gp). (I) have hormonal activity qualitatively equal to that of neurohypophysal hormones. They have esp. natriuretic act. and may be used in the treatment of all types of oedema and general disturbance of the electrolyte metabolism, esp. sodium retention. (I) are more active and are longer lasting in activity than natural (IIe3)-argininvasopressine or known (Leu4) oxytocine, with less hypertensive activity.

公开(公告)号：ZA721155B

公开(公告)日：1972-11-29

申请号：ZA721155

申请日：1972-02-21

Applicant: HOFFMANN LA ROCHE

Inventor： BOGUTH W ,  STUDER R ,  ACHTERRATH U ,  KUNZI H

IPC: C07K5/08 ,  C07K5/097 ,  C07C