公开(公告)号：JPS6422A

公开(公告)日：1989-01-05

申请号：JP8543687

申请日：1987-04-07

Applicant: KAO CORP

Inventor： MURATA SHOICHI ,  NAGASHIMA YOSHINAO ,  HARA KENJI ,  KAYANE SHIGETO ,  IMAMURA TAKASHI

IPC: C07H11/04 ,  A61K31/70 ,  A61P3/00 ,  A61P3/14 ,  A61P7/00 ,  A61P43/00

Abstract: PURPOSE:To obtain a prophylactic preparation or a remedy for diseases caused by insufficiency of calcium in living body tissues, by using calcium hexosephosphate as an active ingredient, thus enabling the drug to be administered for a long period of time without side-actions. CONSTITUTION:Calcium hexose-phosphate, preferably calcium glucose-phosphate is used, as an active ingredient, to give the subject preparation. The preparation has good absorption properties, increases the calcium concentration in blood and strengthens bone strength. The dose of the preparation is 1-50g, preferably 10-30g/day/adult.

公开(公告)号：JP2019025071A

公开(公告)日：2019-02-21

申请号：JP2017148554

申请日：2017-07-31

Applicant: KAO CORP

Inventor： NAGASHIMA YOSHINAO

IPC: A61B5/00 ,  A61B5/026

Abstract: 【課題】顔の肌状態を示す各種情報を取得するための専用測定装置を必要とすることなく、容易に評価可能とする肌状態評価装置を提供する。【解決手段】肌状態評価方法は、被験者の顔面皮膚の血流情報を取得する取得工程(S11)と、取得された血流情報に基づいて当該被験者の顔の肌状態を評価する評価工程(S13)を含む。血流情報は、血流指標値を含み、血流指標値は、皮膚にレーザ光を照射し散乱光を撮像して得られる光強度画像から得る。【選択図】図1

公开(公告)号：JP2009051835A

公开(公告)日：2009-03-12

申请号：JP2008201166

申请日：2008-08-04

Applicant: Kao Corp ,  花王株式会社

Inventor： NAGASHIMA YOSHINAO ,  SUGATA KEIICHI ,  YADA YUKIHIRO ,  FUKUDA KAZUYUKI

IPC: A61K31/045 ,  A23G3/34 ,  A23L1/30 ,  A61K8/02 ,  A61K8/34 ,  A61K9/00 ,  A61K31/05 ,  A61P25/02 ,  A61P25/20 ,  A61P25/22 ,  A61Q13/00 ,  A61Q19/00

CPC classification number: A61K31/045 ,  A61K9/007

Abstract: PROBLEM TO BE SOLVED: To provide an autonomic nerve regulating agent exhibiting sedative action and the like to a person in a condition of excessively sympathetic nerve ascendant and, conversely, exhibiting actions of returning physiologically most suitable conditions to a person in a condition of excessively parasympathetic nerve ascendant, regardless of individual variation in sensitivity to or preference for fragrance. SOLUTION: The autonomic nerve regulating agent, a sleep improver and a stress relaxing agent, each containing a sesquiterpene alcohol having ≥250°C boiling point individually and having odor practically lower than a threshold level. As the sesquiterpene alcohol, cedrol is preferable. The autonomic nerve regulating agent can be applied to sundries such as an indoor fragrance and a mask, and several kinds of fiber products including seat covers, bedclothes, wall paper, interior materials and clothes. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供一种在过度交感神经上升的情况下向人展示镇静作用等的自主神经调节剂，相反地，表现出将生理上最适合的病症恢复到病情的人的作用 过度副交感神经上升，而不考虑对香味敏感度或偏爱度的个体变化。 解决方案：自主神经调节剂，睡眠改善剂和应激缓解剂，各自含有单独具有≥250℃沸点的倍半萜醇，具有低于阈值水平的气味。 作为倍半萜醇，优选雪松醇。 自主神经调节剂可以应用于诸如室内香料和面膜的杂物，以及包括座椅套，床上用品，墙纸，内部材料和衣服在内的几种纤维制品。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2003048827A

公开(公告)日：2003-02-21

申请号：JP2001234832

申请日：2001-08-02

Applicant: Kao Corp ,  花王株式会社

Inventor： ITANO MORIHIDE ,  OSHINO KAZUSHI ,  NAGASHIMA YOSHINAO ,  YADA YUKIHIRO

IPC: A61P25/20 ,  A61K31/045 ,  A61P25/26

Abstract: PROBLEM TO BE SOLVED: To obtain a composition for the oral cavity, which improves sleep quality by use before sleep and activates awakening by use on rising.
SOLUTION: This composition for the oral cavity comprises (A) menthol and (B) a sesquiterpene alcohol having a cedrene skeleton in the content ratio of the component A to the component B [(A):(B)] of 1:0.01-10 by weight.
COPYRIGHT: (C)2003,JPO

Abstract translation: 要解决的问题：获得用于口腔的组合物，其通过在睡眠之前使用来改善睡眠质量并通过使用上升而激活觉醒。 解决方案：该口腔用组合物包含（A）薄荷醇和（B）具有丁二烯骨架的倍半萜烯醇，其组分A与组分B [（A）:( B）]的含量比为1:0.01〜 10重量份。

公开(公告)号：JPH11218446A

公开(公告)日：1999-08-10

申请号：JP32271998

申请日：1998-11-12

Applicant: KAO CORP

Inventor： NAGASHIMA YOSHINAO ,  YONEDA OSATOSHI ,  YADA YUKIHIRO

IPC: G01J3/46 ,  A61B5/107 ,  G01J3/50

Abstract: PROBLEM TO BE SOLVED: To reduce the size and wt. of a colorimetric apparatus to facilitate the colorimetry of the face, improve the durability and facilitate the maintenance. SOLUTION: The colorimetric apparatus has irradiating means having a luminescent diode such as light emitting diode LED as an optical source for irradiating an object S, photodetecting means e.g. photodiode 11 for receiving a reflected light from the object S and outputting a reflected light intensity and operating means for obtaining a colorimetric value, based on the reflected light intensity. The colorimetric apparatus contacts the skin, irradiates a white light on the skin from the irradiating means, receives a reflected light from the skin, resulting from the irradiated light, and obtains the colorimetric value, based on the received light intensity.

公开(公告)号：JPH10113369A

公开(公告)日：1998-05-06

申请号：JP7022597

申请日：1997-03-24

Applicant: KAO CORP

Inventor： NAGASHIMA YOSHINAO ,  MINAMI TAKAHIDE ,  YADA YUKIHIRO

IPC: A61K8/00 ,  A61H7/00 ,  A61K8/11 ,  A61K8/31 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/46 ,  A61K8/49 ,  A61K8/92 ,  A61K8/97 ,  A61K8/98 ,  A61Q90/00 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To easily achieve a large cosmetic effect by massage even by a general person. SOLUTION: Massage is applied in a blood flow direction in an artery, and massage is then applied in a blood flow direction in a vein. In massaging a face in this method, a massage (a) to draw a line from the mouth through the nose wing, a massage (b) to draw a circle on the cheek from the mouth through the lower eyelid toward the eye, a massage (c) to draw an arc on the forehead from around the middle of the forehead through an upper part of the forehead to each end part, and a massage (d) from an inner corner of the eye to an outer corner are performed in a desired order. Otherwise, the massages (a), (b), (c) are repeated by 2-3 times in the order of (a), (b), (c), and the massage (d) is performed by 2-3 times.

公开(公告)号：JPH02250821A

公开(公告)日：1990-10-08

申请号：JP7022089

申请日：1989-03-22

Applicant: KAO CORP

Inventor： NAGASHIMA YOSHINAO ,  MURATA SHOICHI ,  HARA KENJI

IPC: C07H11/04 ,  A61K9/08

Abstract: PURPOSE:To provide a fluid infusion capable of stable coexistence with metals such as calcium, magnesium and trace metals and requiring no pH adjustment by acid, thus excellent in stability, containing a saccharide phosphoric ester salt as phosphorus component. CONSTITUTION:The objective fluid infusion containing 3-65 (pref. 5-10) mmol/l of a saccharide phosphoric ester salt as phosphorus component (e.g. monosaccharide or disaccharide phosphoric ester salt, esp. glucose-1-calcium phosphate. This fluid infusion will not cause precipitation even incorporated with both phosphorus component and inorganic matter, furthermore, requiring no pH adjustment because of the pH buffering ability of the saccharide phosphoric ester; therefore, enabling ready simultaneous administration of phosphorus and inorganic matter with no risk of infectious disease development.

公开(公告)号：JP2006160721A

公开(公告)日：2006-06-22

申请号：JP2005048198

申请日：2005-02-24

Applicant: Kao Corp ,  花王株式会社

Inventor： SADATE HIDETOSHI ,  NAGASHIMA YOSHINAO ,  WATANABE TAKUYA

IPC: A61K31/192 ,  A23L1/30 ,  A61K31/216 ,  A61P3/02 ,  A61P25/00

CPC classification number: A61K31/192 ,  A23L33/10 ,  A61K31/216

Abstract: PROBLEM TO BE SOLVED: To provide an agent for recovery from fatigue of the cerebrum such as decrease of calculation ability based on the fatigue of the cerebrum. SOLUTION: The agent for the recovery from the fatigue of the cerebrum contains at least one kind selected from chlorogenic acids, coffeic acid, ferulic acid and their pharmacologically acceptable salts. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供从大脑疲劳中恢复的药剂，例如基于大脑疲劳的计算能力降低。 解决方案：从大脑疲劳中恢复的药剂含有选自绿原酸，咖啡酸，阿魏酸及其药理学上可接受的盐中的至少一种。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2003052828A

公开(公告)日：2003-02-25

申请号：JP2001245092

申请日：2001-08-10

Applicant: Kao Corp ,  花王株式会社

Inventor： NAGASHIMA YOSHINAO ,  YADA YUKIHIRO

IPC: A61L9/01 ,  A61M21/02

Abstract: PROBLEM TO BE SOLVED: To provide a method for improving the living space environment of human being by using a chemical compound showing the action of calm to a person in an excessively sympathetic nerve dominance state to excess and on the contrary, showing the action of returning to the physiologically optimum state to a person in an excessively parasympathetic nerve dominance state regardless of individual difference in sensitivity and taste to aroma. SOLUTION: The living space environment is improved by volatilizing sesquiterpene alcohols having a boiling point of 250 deg.C or higher to the living space of human being so that the space concentration is 0.01 ppb to 10 ppm.

Abstract translation: 要解决的问题：提供一种通过使用显示平静的动作的化合物来改善人类的生活空间环境的方法，以使过度交感神经优势状态的人过度，并且反过来表现出返回的动作 对于处于过度副交感神经优势状态的人的生理学最佳状态，而与感觉和味道与香气的个体差异无关。 解决方案：通过将沸点为250摄氏度或更高的倍半萜醇挥发到人的生活空间来改善生活空间环境，使得空间浓度为0.01ppb至10ppm。

公开(公告)号：JPH11218447A

公开(公告)日：1999-08-10

申请号：JP32272298

申请日：1998-11-12

Applicant: KAO CORP

Inventor： YONEDA OSATOSHI ,  NAGASHIMA YOSHINAO ,  YADA YUKIHIRO

IPC: G01J3/46 ,  A61B5/107 ,  G01J3/50

Abstract: PROBLEM TO BE SOLVED: To reduce the size and wt. of a colorimetric apparatus to facilitate the colorimetry of the face, improve the durability and facilitate the maintenance. SOLUTION: The colorimetric apparatus comprises irradiating means for irradiating three prim. colors lights on an object S, e.g. LEDR, LEDG, LEDB, photodetecting means e.g. photodiode 11 for receiving reflected lights of the three prim. colors lights from the object S and outputting reflected light intensities and operating means for obtaining colorimetric values, based on the respective reflected light intensities.