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    CHEMICAL SENSOR WITH PROTRUDED SENSOR SURFACE
    21.
    发明申请
    CHEMICAL SENSOR WITH PROTRUDED SENSOR SURFACE 有权
    带传感器表面的化学传感器

    公开(公告)号：US20140264466A1

    公开(公告)日：2014-09-18

    申请号：US13801243

    申请日：2013-03-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Keith G. Fife ,  James Bustillo ,  Jordan Owens

    IPC: G01N27/414

    CPC classification number: G01N27/414

    Abstract: In one implementation, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A dielectric material defines an opening extending to the upper surface of the floating gate conductor. A conductive element on a sidewall of the opening and extending over an upper surface of the dielectric material.

    Abstract translation: 在一个实施方式中，描述了化学传感器。 化学传感器包括具有上表面的浮栅导体的化学敏感场效应晶体管。 介电材料限定了延伸到浮动栅极导体的上表面的开口。 在开口的侧壁上并在电介质材料的上表面上延伸的导电元件。

    Chemical Coating of Microwell for Electrochemical Detection Device
    23.
    发明申请
    Chemical Coating of Microwell for Electrochemical Detection Device 有权
    电化学检测装置的微孔化学涂层

    公开(公告)号：US20130089466A1

    公开(公告)日：2013-04-11

    申请号：US13648663

    申请日：2012-10-10

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Wolfgang Hinz ,  John Mauro ,  Shifeng Li ,  James Bustillo

    IPC: G01N27/26

    CPC classification number: G01N27/4148 ,  C12Q1/6874 ,  G01N27/26 ,  G01N27/414 ,  G01N27/4145 ,  H01L29/78 ,  Y10T436/143333

    Abstract: The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.

    Abstract translation: 所描述的实施例可以提供一种制造化学检测装置的方法。 该方法可以包括在CMOS器件上形成微孔。 微孔可以包括底表面和侧壁。 该方法可以进一步包括施加第一化学物质以选择性地连接到微孔的底表面，在微孔的侧壁上形成金属氧化物层，以及施加第二化学物质以选择性地连接到微孔的侧壁。 第二种化学物质可能与第一种化学物质不具有亲和力。

    Chemical sensor with air via
    24.
    发明授权
    Chemical sensor with air via 有权

    公开(公告)号：US12298271B2

    公开(公告)日：2025-05-13

    申请号：US17570273

    申请日：2022-01-06

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： James Li ,  Jordan Owens ,  James Bustillo

    IPC: G01N27/414 ,  G01N27/12

    Abstract: In one embodiment, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface, a first opening extending through a first material and through a portion of a second material located on the first material and a second opening extending from the bottom of the first opening to the top of a liner layer located on the upper surface of the floating gate conductor.

    Methods and apparatus for measuring analytes using large scale FET arrays
    25.
    发明授权
    Methods and apparatus for measuring analytes using large scale FET arrays 有权

    公开(公告)号：US12140560B2

    公开(公告)日：2024-11-12

    申请号：US17820202

    申请日：2022-08-16

    Applicant: Life Technologies Corporation

    Inventor： Jonathan Rothberg ,  Wolfgang Hinz ,  Kim Johnson ,  James Bustillo

    IPC: G01N27/414 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N33/543 ,  H01L27/088 ,  H01L29/423 ,  H01L29/78

    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

    Chemically-sensitive sensor array device
    28.
    发明授权
    Chemically-sensitive sensor array device 有权

    公开(公告)号：US11435314B2

    公开(公告)日：2022-09-06

    申请号：US17067538

    申请日：2020-10-09

    Applicant: Life Technologies Corporation

    Inventor： Jonathan M. Rothberg ,  Wolfgang Hinz ,  Kim L. Johnson ,  James Bustillo

    IPC: G01N27/414 ,  C12Q1/6874 ,  H01L29/78 ,  H01L27/088 ,  C12Q1/6818 ,  G01N33/543 ,  H01L29/423

    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

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