公开(公告)号：AU2003262674A1

公开(公告)日：2004-02-25

申请号：AU2003262674

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： SPARER RANDALL V ,  HOBOT CHRISTOPHER M ,  DANG KIEM ,  LYU SUPING

IPC: A61K9/00 ,  A61L27/16 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16

公开(公告)号：AU2003258206A1

公开(公告)日：2004-02-25

申请号：AU2003258206

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： SPARER RANDALL V ,  HOBOT CHRISTOPHER M ,  LYU SUPING ,  DANG KIEM

IPC: A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L29/08

公开(公告)号：AU2003258205A1

公开(公告)日：2004-02-25

申请号：AU2003258205

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： LYU SUPING ,  DANG KIEM ,  CHENG PEIWEN ,  SPARER RANDALL V ,  HOBOT CHRISTOPHER M

IPC: A61L27/26 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16

Abstract: The present invention provides active agent delivery systems for use in medical devices, wherein the active agent delivery systems include an active agent and a miscible polymer blend that includes a hydrophobic cellulose derivative and a polyvinyl homopolymer or copolymer selected from the group consisting of a polyvinyl alkylate homopolymer or copolymer, a polyvinyl alkyl ether homopolymer or copolymer, a polyvinyl acetal homopolymer or copolymer, and combinations thereof.

公开(公告)号：CA2495176A1

公开(公告)日：2004-02-19

申请号：CA2495176

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： HOBOT CHRISTOPHER M ,  SPARER RANDALL V ,  LYU SUPING

IPC: A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L31/02 ,  A61L31/08

Abstract: Polymer-coated medical devices having improved structural integrity and drug elution profile, and related methods. Treatment of a polymeric undercoat lay er to reflow the undercoat polymer results in a substrate/coating interface wit h improved adhesion.

公开(公告)号：CA2495172A1

公开(公告)日：2004-02-19

申请号：CA2495172

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： UDIPI KISHORE ,  LYU SUPING ,  SPARER RANDALL V ,  HOBOT CHRISTOPHER M

IPC: A61K9/00 ,  A61L27/26 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/16 ,  A61L27/34

Abstract: The present invention provides active agent delivery systems for use in medical devices, wherein the active agent delivery systems include an active agent and a miscible polymer blend.

公开(公告)号：CA2494186A1

公开(公告)日：2004-02-19

申请号：CA2494186

申请日：2003-08-13

Applicant: MEDTRONIC INC

Inventor： DANG KIEM ,  LYU SUPING ,  SPARER RANDALL V ,  HOBOT CHRISTOPHER M

IPC: A61K9/00 ,  A61L27/16 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16

Abstract: The present invention provides active agent delivery systems for use in medical devices, wherein the active agent delivery systems include an active agent and a miscible polymer blend that includes a polyethylene-co- (meth)acrylate) and a second polymer not including polyethylene vinyl acetat e).

公开(公告)号：CA2467341A1

公开(公告)日：2003-05-22

申请号：CA2467341

申请日：2002-11-13

Applicant: MEDTRONIC INC

Inventor： SCHWENDEMAN JOHN E ,  DIDOMENICO EDWARD ,  BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  WAGENER KENNETH B

IPC: A61L27/18 ,  C08F236/20 ,  C08G18/62 ,  A61L29/00

Abstract: Compounds that include diorgano groups having quaternary carbons and optionally urethane groups, urea groups, or combinations thereof (i.e., polyyurethanes, polyureas, or polyurethane-ureas), as well as materials and methods for making such compounds.

公开(公告)号：AU7474698A

公开(公告)日：1998-11-27

申请号：AU7474698

申请日：1998-05-08

Applicant: MEDTRONIC INC

Inventor： BENZ MICHAEL ERIC ,  BONNEMA KELVIN ,  DIDOMENICO EDWARD ,  HOBOT CHRISTOPHER M ,  MILLER DAVID L

IPC: A61L27/18 ,  A61L27/34 ,  A61L29/06 ,  A61L29/08 ,  A61L31/06 ,  A61L31/10 ,  A61L33/06 ,  A61L27/00

公开(公告)号：DE69028966T2

公开(公告)日：1997-05-07

申请号：DE69028966

申请日：1990-08-22

Applicant: MEDTRONIC INC

Inventor： DIDOMENICO EDWARD D ,  COURY ARTHUR J ,  HOBOT CHRISTOPHER M ,  DOAN PHONG D ,  STOKES KENNETH B ,  SANDSTROM RICHARD D

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/70 ,  A61K47/34 ,  A61M37/00 ,  A61N1/05 ,  A61K9/22

Abstract: A cardiac pacing lead or other stimulation lead carrying a steroid compounded within a polymer matrix. The steroid is dispersed in thermoplastic or thermoset polyurethane or polyurea forming monomers or prepolymers. The mixture is then chain extended by addition of the appropriate difunctional or multifunctional isocyanate, hydroxyl or amine curing agent to form a solid polymer. The resulting formulation is molded or cast into a desired shape, and incorporated in the distal end of a medical electrical lead, adjacent to or within the electrode. In a preferred embodiment, the medical lead employs an extendable helix which is screwed into body tissue, and the polymer containing the drug takes the form of a generally dimensionally stable annular member mounted to the lead, encircling the helix.

公开(公告)号：AU4142389A

公开(公告)日：1990-04-05

申请号：AU4142389

申请日：1989-09-14

Applicant: MEDTRONIC INC

Inventor： COURY ARTHUR J ,  HOBOT CHRISTOPHER M

IPC: C07C271/16 ,  C08G18/32 ,  C08G18/38 ,  C08G18/50 ,  C08G18/61 ,  C08G71/04 ,  C07C271/12 ,  C07D295/20 ,  C07F7/10 ,  C08G65/32