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公开(公告)号：MX373926B
公开(公告)日：2025-03-05
申请号：MX2017003277
申请日：2011-11-24
Applicant: PTC THERAPEUTICS INC
Inventor： TROTTA CHRISTOPHER , CORSON DON , MIAO HARRY H , QI HONGYAN , GRACI JASON D , CAMPBELL JEFF , MILLER LANGDON , CAO LIANGXIAN , WEETALL MARLA L , ALMSTEAD NEIL , HWANG PETER SEONGWOO , CHOI SOONGYU , ARASU TAMIL , DAVIS THOMAS W , LENNOX WILLIAM , MOON YOUNG-CHOON , GU ZHENGXIAN
IPC: A61K31/437 , A01N43/42 , A61K31/44 , A61K31/496 , C07D471/04
Abstract: Se describen compuestos que inhiben selectivamente la producción patológica del factor de crecimiento endotelial vascular humano (VEGF) y las composiciones que contienen tales compuestos. Se describen compuestos que inhiben la replicación viral o la producción de RNA o DNA viral o proteína viral, y las composiciones que contienen tales compuestos. También se describen métodos para disminuir el VEGF empleando tales compuestos y los métodos para tratar cáncer y estados no neoplásicos que incluyen la administración de tales compuestos. Además, están descritos los métodos para inhibir la replicación viral o la reproducción de RNA o DNA viral o proteína viral empleando estos compuestos, y los métodos para tratar infecciones virales que incluyen la administración de tales compuestos. Los compuestos pueden ser administrados como terapia de un solo compuesto o en combinación con una o más terapias adicionales a un humano que necesite de estos tratamientos.
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公开(公告)号：AU2019340402A2
公开(公告)日：2021-04-01
申请号：AU2019340402
申请日：2019-08-17
Applicant: PTC THERAPEUTICS INC , UNIV COLUMBIA
Inventor： WEETALL MARLA L , CAO LIANGXIAN , DAVIS THOMAS W , DUMBLE MELISSA L , EBERLE-SINGH JAIME A , OLIVE KENNETH P
IPC: A61K31/506 , A61K31/337 , A61K31/7068 , A61P35/00
Abstract: A method for treating pancreatic cancer in a subject in need thereof comprising, administering to the subject an effective amount of a tubulin polymerization inhibitor compound is described herein. More particularly, a method for treating pancreatic ductal adenocarcinoma in a subject in need thereof comprising, administering to the subject an effective amount of a substituted reverse pyrimidine tubulin polymerization inhibitor compound alone or in combination with other chemo-therapeutic agents is described herein.
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公开(公告)号：AU2019340402A1
公开(公告)日：2021-03-25
申请号：AU2019340402
申请日：2019-08-17
Applicant: PTC THERAPEUTICS INC , UNIV COLUMBIA
Inventor： WEETALL MARLA L , CAO LIANGXIAN , DAVIS THOMAS W , DUMBLE MELISSA L , EBERLE-SINGH JAIME A , OLIVE KENNETH P
IPC: A61K31/506 , A61K31/337 , A61K31/7068 , A61P35/00
Abstract: A method for treating pancreatic cancer in a subject in need thereof comprising, administering to the subject an effective amount of a tubulin polymerization inhibitor compound is described herein. More particularly, a method for treating pancreatic ductal adenocarcinoma in a subject in need thereof comprising, administering to the subject an effective amount of a substituted reverse pyrimidine tubulin polymerization inhibitor compound alone or in combination with other chemo-therapeutic agents is described herein.
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公开(公告)号：CA2763485C
公开(公告)日：2018-05-15
申请号：CA2763485
申请日：2010-05-27
Applicant: PTC THERAPEUTICS INC
Inventor： ALMSTEAD NEIL , ARASU TAMIL , CHOI SOONGYU , CAO LIANGXIAN , CAMPBELL JEFF , CORSON DON , DAVIS THOMAS W , GRACI JASON D , GU ZHENGXIAN , HWANG PETER SEONGWOO , LENNOX WILLIAM , MIAO HARRY H , MILLER LANGDON , MOON YOUNG-CHOON , QI HONGYAN , TROTTA CHRISTOPHER , WEETALL MARIA L
IPC: C07D471/04 , A01N43/90 , A01N47/16 , A01P1/00 , A61K31/437 , A61K31/44 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/706 , A61P31/12 , A61P35/00 , C12N7/00 , C12N15/00
Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reduc-ing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.
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公开(公告)号：HK1215032A1
公开(公告)日：2016-08-12
申请号：HK16103069
申请日：2016-03-16
Applicant: PTC THERAPEUTICS INC
Inventor： LEE CHANG-SUN , BAIAZITOV RAMIL , CAO LIANGXIAN , DAVIS THOMAS W , DU WU , LIU RONGGANG , MOON YOUNG-CHOON , PAGET STEVEN D , REN HONGYU , SYDORENKO NADIYA , WILDE RICHARD GERALD
IPC: C07D20060101
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Patent Agency Ranking
公开(公告)号：AU2016208323A1
公开(公告)日：2016-08-11
申请号：AU2016208323
申请日：2016-07-27
Applicant: PTC THERAPEUTICS INC
Inventor： ALMSTEAD NEIL , ARASU TAMIL , CHOI SOONGYU , CAO LIANGXIAN , CAMPBELL JEFF , CORSON DON , DAVIS THOMAS W , GRACI JASON D , GU ZHENGXIAN , HWANG PETER SEONGWOO , LENNOX WILLIAM , MIAO HARRY H , MILLER LANGDON , MOON YOUNG-CHOON , QI HONGYAN , TROTTA CHRISTOPHER , WEETALL MARLA L
IPC: C07D471/04 , A01N43/42 , A61K31/44
Abstract: Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments. VEGF Regulation 100- Compound #10 90- Compound 1205 80- o Compound 1330 0--- ------------------------------------ -10 1111111 1 1 11111111 11111111 10-5 10-4 10-3 10-2 10-1 100 Log [uM] Fig. 1
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公开(公告)号：PE20151413A1
公开(公告)日：2015-10-23
申请号：PE2015000665
申请日：2013-11-21
Applicant: PTC THERAPEUTICS INC
Inventor： DU WU , SYDORENKO NADIYA , BAIAZITOV RAMIL , REN HONGYU , DAVIS THOMAS W , PAGET STEVEN D , MOON YOUNG-CHOON , CAO LIANGXIAN , LEE CHANG-SUN , LIU RONGGANG , WILDE RICHARD
IPC: C07D239/48
Abstract: Referido a derivados de pirimidina sustituida con amina de formula (I) y formas de la misma que inhiben la funcion y reducen el nivel de la proteina del sitio de integracion 1 (Bmi-1) del virus de la leucemia de Moloney especifico de celulas B su uso para inhibir la funcion de Bmi-1 y reducir el nivel de Bmi-1 en el tratamiento de un cancer mediado por Bmi-1. Donde R1 es heteroarilo, etc; R2 es H, CN, etc; R3 es H, CN, etc. R4 es cicloalquilo, etc. Los compuestos preferidos son: N-(4-metoxifenil)-2-(2-metil-1H-bencimidazol-1-il)pirimidin-4-amina; N-(2,3-dihidro-1,4-benzodioxin-6-il)-2-(2-metilimidazo[1,2-a]piridin-3-il)pirimidin-4-amina; entre otros
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公开(公告)号：MX2011012513A
公开(公告)日：2012-02-13
申请号：MX2011012513
申请日：2010-05-27
Applicant: PTC THERAPEUTICS INC
Inventor： MOON YOUNG-CHOON , MILLER LANGDON , HWANG PETER SEONGWOO , ALMSTEAD NEIL , ARASU TAMIL , CHOI SOONGYU , CAO LIANGXIAN , CAMPBELL JEFF , CORSON DON , DAVIS THOMAS W , GRACI JASON D , GU ZHENGXIAN , LENNOX WILLIAM , MIAO HARRY H , QI HONGYAN , TROTTA CHRISTOPHER , WEETALL MARLA L
Abstract: Se describen compuestos que inhiben selectivamente la producción patológica del factor de crecimiento endotelial vascular humano (VEGF) y las composiciones que contienen tales compuestos. Se describen compuestos que inhiben la replicación viral o la producción de RNA o DNA viral o proteína viral, y las composiciones que contienen tales compuestos. También se describen métodos para disminuir el VEGF empleando tales compuestos y los métodos para tratar cáncer y estados no neoplásicos que incluyen la administración de tales compuestos. Además están descritos los métodos para inhibir la replicación viral o la reproducción de RNA o DNA viral o proteína viral empleando estos compuestos, y los métodos para tratar infecciones virales que incluyen la administración de tales compuestos. Los compuestos pueden ser administrados como terapia de un solo compuesto o en combinación con una o más terapias adicionales a un humano que necesite de estos tratamientos.
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公开(公告)号：CA2763485A1
公开(公告)日：2010-12-02
申请号：CA2763485
申请日：2010-05-27
Applicant: PTC THERAPEUTICS INC
Inventor： ALMSTEAD NEIL , ARASU TAMIL , CHOI SOONGYU , CAO LIANGXIAN , CAMPBELL JEFF , CORSON DON , DAVIS THOMAS W , GRACI JASON D , GU ZHENGXIAN , HWANG PETER SEONGWOO , LENNOX WILLIAM , MIAO HARRY H , MILLER LANGDON , MOON YOUNG-CHOON , QI HONGYAN , TROTTA CHRISTOPHER , WEETALL MARIA L
IPC: C07D471/04 , A01N43/90 , A01N47/16 , A01P1/00 , A61K31/437 , A61K31/44 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/706 , A61P31/12 , A61P35/00 , C12N7/00 , C12N15/00
Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replication or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.
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公开(公告)号：AU2019340402B2
公开(公告)日：2025-04-03
申请号：AU2019340402
申请日：2019-08-17
Applicant: PTC THERAPEUTICS INC , UNIV COLUMBIA
Inventor： WEETALL MARLA L , CAO LIANGXIAN , DAVIS THOMAS W , DUMBLE MELISSA L , EBERLE-SINGH JAIME A , OLIVE KENNETH P
IPC: A61K31/506 , A61K31/337 , A61K31/7068 , A61P35/00
Abstract: A method for treating pancreatic cancer in a subject in need thereof comprising, administering to the subject an effective amount of a tubulin polymerization inhibitor compound is described herein. More particularly, a method for treating pancreatic ductal adenocarcinoma in a subject in need thereof comprising, administering to the subject an effective amount of a substituted reverse pyrimidine tubulin polymerization inhibitor compound alone or in combination with other chemo-therapeutic agents is described herein.
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