公开(公告)号：HUE052510T2

公开(公告)日：2021-05-28

申请号：HUE10781238

申请日：2010-05-27

Applicant: PTC THERAPEUTICS INC

Inventor： ALMSTEAD NEIL ,  ARASU TAMIL ,  CHOI SOONGYU ,  CAO LIANGXIAN ,  CAMPBELL JEFF ,  CORSON DON ,  DAVIS THOMAS ,  GRACI JASON ,  GU ZHENGXIAN ,  HWANG PETER ,  LENNOX WILLIAM ,  MIAO HARRY ,  MILLER LANGDON ,  MOON YOUNG-CHOON ,  QI HONGYAN ,  TROTTA CHRISTOPHER ,  WEETALL MARLA

IPC: A01N43/42 ,  A61K31/44

公开(公告)号：ES2624610T3

公开(公告)日：2017-07-17

申请号：ES14188816

申请日：2004-04-09

Applicant: PTC THERAPEUTICS INC

Inventor： KARP GARY ,  HWANG SEONGWOO ,  CHEN GUANGMING ,  ALMSTEAD NEIL ,  MOON YOUNG-CHOON

IPC: C07D271/06 ,  A61K31/4245 ,  A61P35/00 ,  C07D271/12 ,  C07D413/04 ,  C07D413/10

Abstract: Un compuesto ácido 3-[5-(2-fluoro-fenil)-[1,2,4]oxadiazol-3-il]-benzoico, que tiene la estructura:**Fórmula** o una sal farmacéuticamente aceptable del mismo.

公开(公告)号：MX2011012517A

公开(公告)日：2012-01-27

申请号：MX2011012517

申请日：2010-05-27

Applicant: PTC THERAPEUTICS INC

Inventor： MOON YOUNG-CHOON ,  HWANG PETER SEONGWOO ,  ALMSTEAD NEIL ,  ARASU TAMIL ,  QI HONGYAN

IPC: C07D471/04 ,  A61K31/44

Abstract: En la presente se proveen procesos mejorados para la síntesis de derivados de tetrahidro beta-carbolina sustituida. En particular, en la presente se proveen procesos mejorados útiles para la preparación de 6-cloro-1-(4-metoxifenil)-3,4-dihidro 1 H-pirido[3,4-b]indol-2(9H)-carboxilato de (S)-4-clorofenilo. Fórmula (I).

公开(公告)号：MX2007004487A

公开(公告)日：2007-06-18

申请号：MX2007004487

申请日：2005-10-13

Applicant: PTC THERAPEUTICS INC

Inventor： REN HONGYU ,  ALMSTEAD NEIL ,  KARP GARY M ,  WELCH ELLEN ,  WILDE RICHARD

IPC: A61K31/00

Abstract: La presente invencion se refiere a metodos, compuestos, y composiciones para tratar o evitar enfermedades relacionadas con mutaciones sin sentido en un ARNm al administrar los compuestos o composiciones de la presente invencion; mas particularmente, la presente invencion se refiere a metodos, compuestos, y composiciones para suprimir la terminacion de la traduccion prematura relacionada con una mutacion si sentido en un ARNm.

公开(公告)号：WO2006044505A3

公开(公告)日：2006-07-06

申请号：PCT/US2005036764

申请日：2005-10-13

Applicant: PTC THERAPEUTICS INC ,  ALMSTEAD NEIL ,  KARP GARY M ,  WILDE RICHARD ,  WELCH ELLEN ,  REN HONGYU

Inventor： ALMSTEAD NEIL ,  KARP GARY M ,  WILDE RICHARD ,  WELCH ELLEN ,  REN HONGYU

IPC: A61K31/44 ,  A61K31/495 ,  A61K31/53

CPC classification number: C07D271/06 ,  C07D231/12 ,  C07D233/64 ,  C07D249/08 ,  C07D251/24 ,  C07D261/08 ,  C07D263/32 ,  C07D271/10 ,  C07D271/107 ,  C07D277/30 ,  C07D285/12 ,  C07D307/68 ,  C07D333/24 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07F9/65306

Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

Abstract translation: 本发明涉及通过施用本发明的化合物或组合物用于治疗或预防与mRNA中的无义突变相关的疾病的方法，化合物和组合物。 更具体地说，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。

公开(公告)号：WO2006044502A2

公开(公告)日：2006-04-27

申请号：PCT/US2005036761

申请日：2005-10-13

Applicant: PTC THERAPEUTICS INC ,  ALMSTEAD NEIL ,  KARP GARY M ,  WILDE RICHARD ,  WELCH ELLEN ,  CAMPBELL JEFFREY A ,  REN HONGYU ,  CHEN GUANGMING

Inventor： ALMSTEAD NEIL ,  KARP GARY M ,  WILDE RICHARD ,  WELCH ELLEN ,  CAMPBELL JEFFREY A ,  REN HONGYU ,  CHEN GUANGMING

CPC classification number: C07D271/06 ,  C07D231/12 ,  C07D233/64 ,  C07D249/08 ,  C07D251/24 ,  C07D261/08 ,  C07D263/32 ,  C07D271/10 ,  C07D271/107 ,  C07D277/30 ,  C07D285/12 ,  C07D307/68 ,  C07D333/24 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07F9/65306

Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

Abstract translation: 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与mRNA中的无义突变有关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。

公开(公告)号：PL2434891T3

公开(公告)日：2020-12-28

申请号：PL10781238

申请日：2010-05-27

Applicant: PTC THERAPEUTICS INC

Inventor： ALMSTEAD NEIL ,  ARASU TAMIL ,  CHOI SOONGYU ,  CAO LIANGXIAN ,  CAMPBELL JEFF ,  CORSON DON ,  DAVIS THOMAS W ,  GRACI JASON D ,  GU ZHENGXIAN ,  HWANG PETER SEONGWOO ,  LENNOX WILLIAM ,  MIAO HARRY H ,  MILLER LANGDON ,  MOON YOUNG-CHOON ,  QI HONGYAN ,  TROTTA CHRISTOPHER ,  WEETALL MARLA L

IPC: A01N43/42 ,  A61K31/44 ,  C07D471/04

公开(公告)号：SG176260A1

公开(公告)日：2012-01-30

申请号：SG2011087632

申请日：2010-05-27

Applicant: PTC THERAPEUTICS INC

Inventor： HWANG PETER SEONGWOO ,  MOON YOUNG-CHOON ,  ARASU TAMIL ,  QI HONGYAN ,  ALMSTEAD NEIL

Abstract: Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro- 1 -(4-methoxyphenyl)-3,4-dihydro- 1 H-pyrido [3,4-b]indole-2(9H)-carboxylate. Formula (I)

公开(公告)号：CA2999345A1

公开(公告)日：2010-12-02

申请号：CA2999345

申请日：2010-05-27

Applicant: PTC THERAPEUTICS INC

Inventor： ALMSTEAD NEIL ,  ARASU TAMIL ,  CHOI SOONGYU ,  CAO LIANGXIAN ,  CAMPBELL JEFF ,  CORSON DON ,  DAVIS THOMAS ,  GRACI JASON D ,  GU ZHENGXIAN ,  HWANG PETER SEONGWOO ,  LENNOX WILLIAM ,  MIAO HARRY H ,  MILLER LANGDON ,  MOON YOUNG-CHOON ,  QI HONGYAN ,  TROTTA CHRISTOPHER ,  WEETALL MARLA L

IPC: A61K31/437 ,  A61P35/00 ,  A61P35/02

Abstract: Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of reducing VEGF using such Compounds and methods for treating cancer and non-neoplastic conditions involving the administration of such Compounds. Further described are methods of inhibiting viral replications or the production of viral RNA or DNA or viral protein using such Compounds and methods for treating viral infections involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one ore more additional therapies to a human in need of such treatment.

公开(公告)号：BRPI0516110A

公开(公告)日：2008-08-26

申请号：BRPI0516110

申请日：2005-10-13

Applicant: PTC THERAPEUTICS INC

Inventor： ALMSTEAD NEIL ,  KARP GARY M ,  WELCH ELLEN ,  WILDE RICHARD ,  CAMPBELL JEFFREY A ,  CHEN GUANGMING

IPC: F28G3/10

Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.