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公开(公告)号：BRPI0813657A2
公开(公告)日：2016-10-18
申请号：BRPI0813657
申请日：2008-06-23
Applicant: SOLVAY PHARM BV
Inventor： STOIT AXEL , KRUSE CORNELIS G , TURSKI LECHOSLAW A , TULP MARTINUS TH M , VADER SANDER
IPC: C07D487/04 , A61K31/519 , A61P11/00 , A61P15/10
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公开(公告)号：ZA200908868B
公开(公告)日：2010-09-29
申请号：ZA200908868
申请日：2009-12-11
Applicant: SOLVAY PHARM BV
Inventor： TURSKI LECHOSLAW A , STOIT AXEL , KRUSE CORNELIS G , VADER SANDER , TULP MARTINUS TH M
IPC: A61K20060101 , A61P20060101 , C07D20060101
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Patent Agency Ranking
公开(公告)号：AU2005205067B2
公开(公告)日：2009-10-22
申请号：AU2005205067
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： IKONOMIDOU HRISSANTHI , WESKE MICHAEL , TURSKI LECHOSLAW A , ZIEGLER DIETER
IPC: A61K31/55
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：SI1706121T1
公开(公告)日：2009-02-28
申请号：SI200530457
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
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公开(公告)号：DK1706121T3
公开(公告)日：2009-01-05
申请号：DK05701469
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：CA2699961A1
公开(公告)日：2008-12-31
申请号：CA2699961
申请日：2008-06-23
Applicant: SOLVAY PHARM BV
Inventor： TURSKI LECHOSLAW A , STOIT AXEL , KRUSE CORNELIS G , VADER SANDER , TULP MARTINUS TH M
IPC: C07C291/04 , A61K31/135 , A61P25/24
Abstract: The invention concerns venlafaxine-N-oxide and O-desmethylvenlafaxine-N-oxide as prodrugs of venlafaxine and its major (active) metabolite O-desmethylvenlafaxine respectively, to pharmaceutical compositions containing these N-oxides, to methods for preparing them, and methods for preparing compositions. The invention relates to N-oxide, having formula (1), wherein R1 is H or CH3, and tautomers, stereoisomers, hydrates and solvates thereof. The invention also relates to the uses of the N-oxides and compositions, particularly for the manufacture of medicaments useful in the treatment of affections or diseases effectively treatable - albeit with side effects - with venlafaxine.
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公开(公告)号：HK1109568A1
公开(公告)日：2008-06-13
申请号：HK08100232
申请日：2008-01-09
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
IPC: A61K20060101 , A61P20060101
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