公开(公告)号：DE3689036T2

公开(公告)日：1994-04-14

申请号：DE3689036

申请日：1986-12-02

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  HASHIMOTO NAOTO

IPC: A61K31/365 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/00 ,  C07D311/00 ,  C07D313/00 ,  C07D493/08 ,  C07H15/00

公开(公告)号：MX9203229A

公开(公告)日：1992-07-01

申请号：MX9203229

申请日：1992-06-24

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  HASHIMOTO NAOTO

IPC: A61K31/365 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/00 ,  C07D311/00 ,  C07D313/00 ,  C07D493/08 ,  C07H15/00 ,  C07G11/00

公开(公告)号：HU202235B

公开(公告)日：1991-02-28

申请号：HU502486

申请日：1986-12-04

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HASHIMOTO NAOTO ,  MINAMIDA ISAO

IPC: A61K31/365 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/00 ,  C07D311/00 ,  C07D313/00 ,  C07D493/08 ,  C07H15/00 ,  C07D493/02 ,  A61K31/335 ,  C12P17/08

公开(公告)号：BR8605962A

公开(公告)日：1987-09-15

申请号：BR8605962

申请日：1986-12-04

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  HASHIMOTO NAOTO

IPC: A61K31/365 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/00 ,  C07D311/00 ,  C07D313/00 ,  C07D493/08 ,  C07H15/00 ,  A23K1/17

公开(公告)号：DE3273121D1

公开(公告)日：1986-10-16

申请号：DE3273121

申请日：1982-05-15

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HASHIMOTO NAOTO ,  SHIMADZU HIROSHI

IPC: A01N43/90 ,  A61K31/535 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  C07D498/18

Abstract: This invention relates to 9-thiomaytansinoid compounds represented by the formula wherein R is hydrogen or acyl derived from a carboxylic acid, X is chlorine or hydrogen, Y is hydrogen, lower alkylsulfonyl, or alkyl or aralkyl which are unsubstituted or substituted, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.

公开(公告)号：CA1169423A

公开(公告)日：1984-06-19

申请号：CA403181

申请日：1982-05-18

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HASHIMOTO NAOTO ,  SHIMADZU HIROSHI

IPC: A01N43/90 ,  A61K31/535 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  C07D498/18

Abstract: Novel 9-thiomaytansinoid compounds represented by the formula (I) wherein R is hydrogen or acyl derived from a carboxylic acid, X is chlorine or hydrogen, Y is hydrogen, lower alkylsulfonyl, or alkyl or aralkyl which are unsubstituted or substituted are disclosed, as well as methods for their production. The compounds (I) are useful as antitumor, antiprotozoal and antifungal agents.

公开(公告)号：CA1124244A

公开(公告)日：1982-05-25

申请号：CA327260

申请日：1979-05-09

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MATSUMURA KOICHI ,  HASHIMOTO NAOTO ,  FURUKAWA YOSHIYASU

IPC: A61K31/415 ,  A61P7/10 ,  A61P9/12 ,  C07D233/68 ,  C07D333/00 ,  C07D405/04 ,  C07D409/04

Abstract: Novel imidazole derivatives of the fonmula wherein Rl is hydrogen, nitro or amine, R2 is a phenyl, furyl or thienyl group which may be substituted by halogen, lower alkyl, lower alkoxy or di-lower-alkylsmino, R3 is hydrogen or lower alkyl and X is halogen, and their physiologically acceptable salts, have excellent diuretic and hypotensive actions.

公开(公告)号：PH14553A

公开(公告)日：1981-09-24

申请号：PH19603

申请日：1977-03-31

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MIYASHITA OSAMU ,  SHIMADZU HIROSHI ,  MATSUMURA KOICHI ,  HASHIMOTO NAOTO

IPC: A61K31/513 ,  A61P35/00 ,  C07C273/18 ,  C07C275/20 ,  C07C275/50 ,  C07D239/22 ,  C07D239/54 ,  C07D239/553 ,  C07D239/557 ,  C07D405/04 ,  C07F7/18 ,  A61K31/505 ,  C07D239/00

Abstract: New derivatives of the formula: (wherein X is O or NH; R1 is -OH which may optionally be etherified or esterified, etherified mercapto or -NH2 which may optionally be substituted; R2 and R3, respectively, mean H, lower alkyl or and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4-tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions. The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity.

公开(公告)号：NO791597L

公开(公告)日：1979-11-16

申请号：NO791597

申请日：1979-05-14

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MATSUMURA KOICHI ,  HASHIMOTO NAOTO ,  FURUKAWA YOSHIYASU

IPC: A61K31/415 ,  A61P7/10 ,  A61P9/12 ,  C07D233/68 ,  C07D333/00 ,  C07D405/04 ,  C07D409/04 ,  C07D

Abstract: Novel imidazole derivatives of the formulawherein R' is hydrogen, nitro or amino, R 2 is a phenyl, furyl or thienyl group which may be substituted by halogen, lower alkyl, lower alkoxy or di-lower-alkylamino, R 3 is hydrogen or lower alkyl and X is halogen, and their physiologically acceptable salts, have excellent diuretic and hypotensive actions.

公开(公告)号：DE2849090A1

公开(公告)日：1979-05-17

申请号：DE2849090

申请日：1978-11-11

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HASHIMOTO NAOTO ,  KISHI TOYOKAZU

IPC: C07D498/04 ,  C07D498/18 ,  C07D498/12