公开(公告)号：CH615190A5

公开(公告)日：1980-01-15

申请号：CH403979

申请日：1979-04-30

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D277/34 ,  C07D277/36 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36

Abstract: A compound of the formula: wherein R1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR2 (where R2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R1), and Y represents acetoxy group or a group of formula -SR3 (where R3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

公开(公告)号：HU172547B

公开(公告)日：1978-09-28

申请号：HUTA001336

申请日：1974-12-23

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D501/26 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46

公开(公告)号：NO772170A

公开(公告)日：1978-03-09

申请号：NO772170

申请日：1977-06-20

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  TSUSHIMA SUSUMU

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D257/04 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D499/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60 ,  C07D

CPC classification number: C07D501/34 ,  C07D501/24

公开(公告)号：NO771111A

公开(公告)日：1977-10-04

申请号：NO771111

申请日：1977-03-29

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  YAMAOKA MASAYOSHI ,  MINAMIDA ISAO ,  SHIRAISHI MITSURU ,  NISHIMURA TATSUO

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60 ,  C07D

CPC classification number: C07D501/20 ,  C07D501/24

公开(公告)号：DE2461478A1

公开(公告)日：1976-02-26

申请号：DE2461478

申请日：1974-12-24

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D277/34 ,  C07D277/36 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36

Abstract: A compound of the formula: wherein R1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR2 (where R2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R1), and Y represents acetoxy group or a group of formula -SR3 (where R3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

公开(公告)号：DE1933985A1

公开(公告)日：1970-01-15

申请号：DE1933985

申请日：1969-06-30

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NOGUCHI SHUNSAKU ,  OBAYASHI MIKIHIKO ,  KISHIMOTO SHOJI ,  MINAMIDA ISAO ,  KAWAI KIYOSHISA

IPC: A61K31/19 ,  B60R13/10 ,  C07D231/06 ,  C07C63/50

公开(公告)号：JPH07278094A

公开(公告)日：1995-10-24

申请号：JP3624095

申请日：1995-01-31

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： UNEME HIDEKI ,  IWANAGA KOICHI ,  HIGUCHI NORIKO ,  MINAMIDA ISAO ,  OKAUCHI TETSUO

IPC: C07D277/28 ,  A01N47/44 ,  A01N51/00 ,  C07C279/06 ,  C07C279/10 ,  C07C279/14 ,  C07D213/38 ,  C07D213/64 ,  C07D241/12 ,  C07D277/20 ,  C07D277/32 ,  C07D277/34 ,  C07D277/42 ,  C07D521/00

Abstract: PURPOSE:To obtain a safe guanidine derivative low in toxicity against men, livestock, fishes and natural enemies, and useful as an insecticide by reacting specific compounds with each other. CONSTITUTION:This derivative of formula I [R is a homogeneous ring consisting of a 3-8C cycloalkyl, a 3-8C cycloalkenyl or a 6-14C aryl, or a five- seven membered heterocyclic ring containing 1-5 heteroatoms selected from O, S and N; R is H or a hydrocarbon such as 1-15C alkyl, 3-10C cyclcoalkyl, 2-10C alkenyl or alkynyl; R is a group of formula II (R , R are H, (substituted) hydrocarbon, etc.); X is cyano, nitro, 1-4C alkoxy-carbonyl, etc.] is obtained by reacting a compound of formula III (Y is a releasable group) with a compound of formula IV. The objective derivative includes 1-(6-chloro-3- pyridylmethyl)-2-cyano-1-ethyl-3-methylguanidine.

公开(公告)号：JPH05345761A

公开(公告)日：1993-12-27

申请号：JP811593

申请日：1993-01-21

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  IWANAGA KOICHI ,  OKAUCHI TETSUO

IPC: C07D213/61 ,  A01N33/18 ,  A01N35/08 ,  A01N43/40 ,  A01N43/42 ,  A01N43/60 ,  A01N43/78 ,  A01N47/24 ,  A01N55/00 ,  C07C211/22 ,  C07C211/29 ,  C07C229/34 ,  C07C243/10 ,  C07C311/50 ,  C07D20060101 ,  C07D213/24 ,  C07D213/38 ,  C07D213/40 ,  C07D213/42 ,  C07D213/64 ,  C07D213/70 ,  C07D213/74 ,  C07D213/77 ,  C07D215/12 ,  C07D215/38 ,  C07D239/26 ,  C07D241/12 ,  C07D277/20 ,  C07D277/22 ,  C07D277/28 ,  C07D277/32 ,  C07D277/38 ,  C07D277/42 ,  C07D295/13 ,  C07D295/30 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07F7/08

Abstract: PURPOSE:To obtain a new compound useful as a synthetic intermediate for new alpha-unsaturated amines having excellent insecticidal and acaricidal action as an agricultural chemical. CONSTITUTION:The objective compound of formula I (either of X and X is electron attractive group and the other is H or electron attractive group; R is a group through C, N or O; n is 0-2; A is substitutable heterocyclic ring; Z is Cl or SR ; R is 1-4C alkyl or aralkyl), e.g. 1-[N-(2,6-dichloro-3- pyridylmethyl)-N-methyl]amino-1-methylthio-2-nitroethylene. This compound of formula I is obtained by reacting a compound of formula II with a compound of formula III (Y is H or alkali metal), providing a compound of formula IV and then reacting the resultant compound of formula IV with an amino compound of the formula R -Y. The reaction is carried out in a solvent such as methanol or benzene at 30-150 deg.C for 5min to 48hr, and, as necessary, using a base (e.g. triethylamine).

公开(公告)号：JPH05345760A

公开(公告)日：1993-12-27

申请号：JP811493

申请日：1993-01-21

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  IWANAGA KOICHI ,  OKAUCHI TETSUO

IPC: C07D213/61 ,  A01N33/18 ,  A01N35/08 ,  A01N43/40 ,  A01N43/42 ,  A01N43/60 ,  A01N43/78 ,  A01N47/24 ,  A01N55/00 ,  C07C211/22 ,  C07C211/29 ,  C07C229/34 ,  C07C243/10 ,  C07C311/50 ,  C07D20060101 ,  C07D213/24 ,  C07D213/38 ,  C07D213/40 ,  C07D213/42 ,  C07D213/64 ,  C07D213/70 ,  C07D213/74 ,  C07D213/77 ,  C07D215/12 ,  C07D215/38 ,  C07D239/26 ,  C07D241/12 ,  C07D277/20 ,  C07D277/22 ,  C07D277/28 ,  C07D277/32 ,  C07D277/38 ,  C07D277/42 ,  C07D295/13 ,  C07D295/30 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07F7/08

Abstract: PURPOSE:To obtain new compounds useful as a synthetic intermediate for agricultural chemicals having excellent insecticidal and acaricidal action. CONSTITUTION:The objective compounds of formula I (Hal is halogen; R is a group through C, N or O or NH-R is phthalimide), e.g. N-(6-chloro-3- pyridylmethyl)-N-methylamine. These compounds of formula I are obtained by reacting a compound of formula II (either of X and X is electron attractive group and the other is H or electron attractive group; R is 1-4C alkyl or aralkyl) with an amino compound of formula III (Y is H or alkali metal; A is 6-halogeno-3-pyridyl), providing a compound of formula IV and then reacting the resultant compound of formula IV with a compound of the formula R -Y (R is a group through N). The reaction is carried out in a solvent such as ethanol or DMF at 30-150 deg.C for 5min to 48hr. The compounds of formula I can be used as a synthetic intermediate and thereby converted into alpha-unsaturated amines having excellent insecticidal effects.

公开(公告)号：JPH04356481A

公开(公告)日：1992-12-10

申请号：JP19041891

申请日：1991-07-30

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： IWANAGA KOICHI ,  MINAMIDA ISAO ,  OKAUCHI TETSUO

IPC: A01N43/50 ,  A01N43/54 ,  A01N43/82 ,  A01N43/836 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/04 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06

Abstract: PURPOSE:To provide a new compound having low toxicity and strong insecticidal action and useful for hygienic use and horticultural use, especially as a vermin-controlling agricultural chemical. CONSTITUTION:The compound of formula I [Q and Q are carbonyl, S or (substituted)methylene; Q is (substituted)methylene or a bond when at least one of Q and Q is carbonyl, and Q is a bond when Q and Q are S; Q is H, (substituted)hydrocarbon group, group bonded through carbonyl, group bonded through S, etc.; Z is electron-attracting group; Y is N, etc.; Het is (substituted) heterocyclic group; (n) is 0-2], e.g. 1-(2-chloro-5-thiazolylmethyl)-3-methyl-2- nitroiminoimidazolidine-4,5-dione. The compound of formula I can be produced by reacting a compound of formula II with a compound of formula III (X is eliminable group).