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    PROCESS FOR PREPARING QUINOLYLACRYLONITRILE AND INTERMEDIATES THEREFOR
    24.
    发明专利
    PROCESS FOR PREPARING QUINOLYLACRYLONITRILE AND INTERMEDIATES THEREFOR 未知

    公开(公告)号：CA2398113C

    公开(公告)日：2010-01-05

    申请号：CA2398113

    申请日：2001-01-24

    Applicant: UBE INDUSTRIES ,  NISSAN CHEMICAL IND LTD

    Inventor： NISHINO SHIGEYOSHI ,  OKADA NAOKO ,  HARADA KATSUMASA ,  SHIMA HIDETAKA ,  HARADA TAKASHI

    IPC: C07D215/12 ,  C07D215/14

    Abstract: 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3- quinolyl]prop-2-enenitrile represented by (3) is prepared by reacting 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3- carbaldehyde represented by (1) with acetonitrile in the presence of a base and then adding a dehydrating to the reaction mixture to conduct dehydration. Under ordinary conditions, novel 3-[2-cyclopropyl-4-(4-fluorophenyl)- quinolin-3-yl]-3-hydroxypropionitrile represented by (2) is formed as an intermediate in the above reaction. Incidentally, when the above reaction is conducted in an organic solvent, 3-[2-cyclopropyl-4-(4-fluorophenyl)-3- quinolyl]-prop-2-enenitrile is directly formed. (see formula 1) (see formula 2) (see formula 3)

    26.
    发明专利
    未知

    公开(公告)号：DE60317519D1

    公开(公告)日：2007-12-27

    申请号：DE60317519

    申请日：2003-06-10

    Applicant: UBE INDUSTRIES

    Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  SUZUKI SHINOBU

    IPC: C07D309/12

    Abstract: The present invention relates to a process for preparing tetrahydropyran-4-ol which comprises the steps of (A) a cyclization step of preparing tetrahydropyranyl-4-formate represented by the formula (1): by reacting 3-buten-1-ol, a formaldehyde compound and formic acid, and (B) then, a solvolysis step of subjecting the tetrahydropyranyl-4-formate to solvolysis to obtain tetrahydropyran-4-ol represented by the formula (2): and an intermediate and a process for preparing the same.

    PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND
    29.
    发明专利
    PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND 未知

    公开(公告)号：AU2003207291A1

    公开(公告)日：2003-09-02

    申请号：AU2003207291

    申请日：2003-02-06

    Applicant: UBE INDUSTRIES

    Inventor： HARADA TAKASHI ,  ODA HIROYUKI ,  NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA

    IPC: C07D239/88 ,  C07D239/94 ,  C07D239/86

    Abstract: Preparation of an optionally substituted 4-aminoquinazoline compound (III) involves: (i) reacting the corresponding quinazolin-4-one compound (I) with a chlorinating agent in a first organic solvent in the presence of an organic base; and (ii) reacting the product with ammonia or amine (II) in a second organic solvent. Preparation of a 4-aminoquinazoline compound of formula (III) involves: (i) reacting a quinazolin-4-one compound of formula (I) with a chlorinating agent in a first organic solvent in the presence of an organic base; and (ii) reacting the product with ammonia or amine of formula R 5>NHR 6>(II) in a second organic solvent. [Image] R 1>-R 4>group which is inert in the reaction conditions; and R 5>, R 6>H or substituent. An independent claim is also included for the preparation of 6-halo-4-chloroquinazoline of formula (VII) from 6-halo-quinazolin-4-one of formula (VI). [Image] X : halo; and Ar' : optionally substituted aryl.

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