公开(公告)号：AT533750T

公开(公告)日：2011-12-15

申请号：AT03703218

申请日：2003-02-06

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  HARADA TAKASHI ,  ODA HIROYUKI

IPC: C07D239/86 ,  C07D239/88 ,  C07D239/94

Abstract: Preparation of an optionally substituted 4-aminoquinazoline compound (III) involves: (i) reacting the corresponding quinazolin-4-one compound (I) with a chlorinating agent in a first organic solvent in the presence of an organic base; and (ii) reacting the product with ammonia or amine (II) in a second organic solvent. Preparation of a 4-aminoquinazoline compound of formula (III) involves: (i) reacting a quinazolin-4-one compound of formula (I) with a chlorinating agent in a first organic solvent in the presence of an organic base; and (ii) reacting the product with ammonia or amine of formula R 5>NHR 6>(II) in a second organic solvent. [Image] R 1>-R 4>group which is inert in the reaction conditions; and R 5>, R 6>H or substituent. An independent claim is also included for the preparation of 6-halo-4-chloroquinazoline of formula (VII) from 6-halo-quinazolin-4-one of formula (VI). [Image] X : halo; and Ar' : optionally substituted aryl.

公开(公告)号：ES2362734T3

公开(公告)日：2011-07-12

申请号：ES04748126

申请日：2004-07-30

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  ODA HIROYUKI ,  SUZUKI SHINOBU

IPC: C07D239/88 ,  C07C67/31

Abstract: Un procedimiento para la preparación de 6,7-bis(2-metoxietoxi)quinazolin-4-ona, el cual comprende las etapas de hacer reaccionar 4,5-bis(2-metoxietoxi)-2-nitrobenzoato de etilo con hidrógeno en la presencia de un catalizador metálico para preparar el 2-amino-4,5-bis(2-metoxietoxi)benzoato de etilo, y posteriormente hacer reaccionar el 2- 5 amino-4,5-bis(2-metoxietoxi)benzoato de etilo con un éster ortofórmico en la presencia de acetato de amonio.

公开(公告)号：ES2328029T3

公开(公告)日：2009-11-06

申请号：ES03703066

申请日：2003-01-28

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  HARADA TAKASHI ,  ODA HIROYUKI ,  TAKAHASHI TAKESHI

IPC: C07D239/88 ,  C07C201/08 ,  C07C205/59 ,  C07C205/60 ,  C07C227/04 ,  C07C229/56 ,  C07C229/64 ,  C07D239/90

Abstract: Un proceso para preparar un compuesto de quinazolin-4-ona que tiene la fórmula (2): en la cual cada uno de R 1 , R 2 , R 3 y R 4 representa independientemente un grupo que no participa en la reacción mencionada a continuación, que comprende hacer reaccionar un compuesto de ácido antranílico que tiene la fórmula (1): en la cual R 1 , R 2 , R 3 y R 4 tienen el mismo significado que anteriormente, y R 5 representa un átomo de hidrógeno o un grupo hidrocarbilo, con un derivado de ácido fórmico seleccionado del grupo constituido por ésteres de ácido fórmico y ésteres de ácido ortofórmico en presencia de un carboxilato alifático de amonio o un carboxilato aromático de amonio.

公开(公告)号：DE60317519T2

公开(公告)日：2008-09-25

申请号：DE60317519

申请日：2003-06-10

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  SUZUKI SHINOBU

IPC: C07D309/12

Abstract: The present invention relates to a process for preparing tetrahydropyran-4-ol which comprises the steps of (A) a cyclization step of preparing tetrahydropyranyl-4-formate represented by the formula (1): by reacting 3-buten-1-ol, a formaldehyde compound and formic acid, and (B) then, a solvolysis step of subjecting the tetrahydropyranyl-4-formate to solvolysis to obtain tetrahydropyran-4-ol represented by the formula (2): and an intermediate and a process for preparing the same.

公开(公告)号：ES2294296T3

公开(公告)日：2008-04-01

申请号：ES03736125

申请日：2003-06-10

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  SUZUKI SHINOBU

IPC: C07D309/12

Abstract: Un procedimiento para preparar tetrahidropiran-4-ol, que comprende las etapas de: (A) una etapa de ciclación para preparar 4-formiato de tetrahidropiranilo representado por la fórmula (1): haciendo reaccionar 3-buten-1-ol, un compuesto de formaldehído y ácido fórmico, y (B) después, una etapa de solvólisis que somete al 4-formiato de tetrahidropiranilo a solvólisis, para obtener tetrahidropiran-4-ol representado por la fórmula (2):

公开(公告)号：AT378324T

公开(公告)日：2007-11-15

申请号：AT03736125

申请日：2003-06-10

Applicant: UBE INDUSTRIES

Inventor： NISHINO SHIGEYOSHI ,  HIROTSU KENJI ,  SHIMA HIDETAKA ,  SUZUKI SHINOBU

IPC: C07D309/12

Abstract: The present invention relates to a process for preparing tetrahydropyran-4-ol which comprises the steps of (A) a cyclization step of preparing tetrahydropyranyl-4-formate represented by the formula (1): by reacting 3-buten-1-ol, a formaldehyde compound and formic acid, and (B) then, a solvolysis step of subjecting the tetrahydropyranyl-4-formate to solvolysis to obtain tetrahydropyran-4-ol represented by the formula (2): and an intermediate and a process for preparing the same.

公开(公告)号：SK10812002A3

公开(公告)日：2003-03-04

申请号：SK10812002

申请日：2001-01-24

Applicant: UBE INDUSTRIES ,  NISSAN CHEMICAL IND LTD

Inventor： HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  OKADA NAOKO ,  SHIMA HIDETAKA ,  HARADA TAKASHI

IPC: C07D215/12 ,  C07D215/14

Abstract: 3-Ä2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜprop-2-enenitrite is prepared by reacting 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base and then adding a dehydrating to the reaction mixture to conduct dehydration. Under ordinary conditions, novel 3-Ä2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylÜ-3-hydroxypropionitrile is formed as an intermediate in the above reaction. Incidentally, when the above reaction is conducted in an organic solvent, 3-Ä2-cyclopropyl-4-(4-fluorophenyl)-3-quinolylÜ-prop-2-enenitrite is directly formed.

公开(公告)号：CA2398113A1

公开(公告)日：2001-07-26

申请号：CA2398113

申请日：2001-01-24

Applicant: UBE INDUSTRIES ,  NISSAN CHEMICAL IND LTD

Inventor： HARADA TAKASHI ,  HARADA KATSUMASA ,  NISHINO SHIGEYOSHI ,  OKADA NAOKO ,  SHIMA HIDETAKA

IPC: C07D215/12 ,  C07D215/14

Abstract: 3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-enenitrile is prepared by reacting 2-cyclopropyl-4- (4-fluorophenyl)quinoline-3-carbaldehyde with acetonitrile in the presence of a base and then adding a dehydrating agent t o the reaction mixture to conduct dehydration. Under ordinary conditions, nove l 3-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3-hydroxypropionitrile is formed as an intermediate in the above reaction. Incidentally, when the abov e reaction is conducted in an organic solvent, 3-[2- cyclopropyl-4-(4- fluorophenyl)-3-quinolyl]prop-2-enenitrile is directly formed.

公开(公告)号：DE112015005812T5

公开(公告)日：2017-09-14

申请号：DE112015005812

申请日：2015-12-25

Applicant: UBE INDUSTRIES

Inventor： SHIMA HIDETAKA ,  OMATA YOUJI

IPC: C07C381/00 ,  C07B61/00

Abstract: Verfahren zur Herstellung einer stickstoffhaltigen Pentafluorsulfanylbenzol-Verbindung der Formel (2a) oder (2b):(wobei R1 ein Wasserstoffatom oder eine Kohlenwasserstoffgruppe ist; Z eine mit einer Carbonylgruppe verbundene Arylgruppe ist; Y eine Gruppe der Formel (Y1), (Y2), (Y3), oder (Y4) ist; R2 ein Wasserstoffatom oder eine Kohlenwasserstoffgruppe ist)wobei das Verfahren das Umsetzen einer Halogen-Pentafluorsulfanylbenzol-Verbindung der Formel (1) mit einem stickstoffhaltigen Nucleophil umfasst:(wobei X ein Halogenatom ist; n eine ganze Zahl von 1 bis 5 ist; R1 wie oben definiert ist).

公开(公告)号：DE112015005812B4

公开(公告)日：2018-12-27

申请号：DE112015005812

申请日：2015-12-25

Applicant: UBE INDUSTRIES

Inventor： SHIMA HIDETAKA ,  OMATA YOUJI

IPC: C07C381/00 ,  C07B61/00

Abstract: Verfahren zur Herstellung einer stickstoffhaltigen Pentafluorsulfanylbenzol-Verbindung der Formel (2a) oder (2b):(wobei Rein Wasserstoffatom oder eine Kohlenwasserstoffgruppe ist; Z eine mit einer Carbonylgruppe verbundene Arylgruppe ist; Y eine Gruppe der Formel (Y1), (Y2), (Y3), oder (Y4) ist; Rein Wasserstoffatom oder eine Kohlenwasserstoffgruppe ist)wobei das Verfahren das Umsetzen einer Halogen-Pentafluorsulfanylbenzol-Verbindung der Formel (1) mit einem stickstoffhaltigen Nucleophil umfasst:(wobei X ein Halogenatom ist; n eine ganze Zahl von 1 bis 5 ist; Rwie oben definiert ist).