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公开(公告)号：CA2774692A1
公开(公告)日：2011-03-31
申请号：CA2774692
申请日：2010-09-23
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a. a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b. a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c. a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated Deg P gene and optionally a polynucleotide sequence encoding a protein of interest.
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公开(公告)号：CA2785931C
公开(公告)日：2019-07-30
申请号：CA2785931
申请日：2011-01-13
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
IPC: C12N1/21 , C07K16/24 , C12N9/48 , C12N9/90 , C12N15/00 , C12N15/57 , C12N15/63 , C12N15/70 , C12P21/02
Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non-recombinant wild-type chromosomal Tsp gene.
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公开(公告)号：EA031449B1
公开(公告)日：2019-01-31
申请号：EA201490274
申请日：2012-07-13
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
Abstract: Изобретениеотноситсяк рекомбинантнойграмотрицательнойбактериальнойклетке, содержащеймутантныепротеазы, экспрессирующийвектор, содержащийрекомбинантныйполинуклеотид, кодирующий DsbC, иодинилинесколькополинуклеотидов, кодирующихантителоилиегоантигенсвязывающийфрагмент, специфическисвязывающийсяс CD154.
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公开(公告)号：CA2786336C
公开(公告)日：2018-09-04
申请号：CA2786336
申请日：2011-01-13
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
IPC: C07K14/245 , C12N15/70
Abstract: The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell: a. comprises a recombinant polynucleotide encoding DsbC; and b. has reduced Tsp protein activity compared to a wild-type cell.
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公开(公告)号：CA2786335C
公开(公告)日：2017-10-10
申请号：CA2786335
申请日：2011-01-13
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
IPC: C12N15/70 , C07K14/245
Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and wherein the cell has reduced Tsp protein activity compared to a wild-type cell.
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Patent Agency Ranking
公开(公告)号：AU2017200545A1
公开(公告)日：2017-02-23
申请号：AU2017200545
申请日：2017-01-27
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non recombinant wild-type chromosomal Tsp gene. 8846157 1 (GHMailers- P90772 A[ J 1 27-Jn-17
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27.发明专利
公开(公告)号：BR112012006670A2
公开(公告)日：2015-09-08
申请号：BR112012006670
申请日：2010-09-23
Applicant: UCB PHARMA SA
Inventor： HUMPREYS DAVID PAUL , ELLIS MARK
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公开(公告)号：MX2014000302A
公开(公告)日：2014-02-17
申请号：MX2014000302
申请日：2012-07-13
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
Abstract: La presente invención proporciona una célula bacteriana gram-negativa recombinante que comprende un vector de expresión, que comprende un polinucleótido que codifica DsbC y uno o más polinucleótidos que codifican un anticuerpo o un fragmento de unión al antígeno del mismo especialmente de unión a CD154.
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公开(公告)号：CA2841824A1
公开(公告)日：2013-01-17
申请号：CA2841824
申请日：2012-07-13
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector, comprising a recombinant polynucleotide encoding DsbC and one or more polynucleotides encoding an antibody or an antigen binding fragment thereof specifically binding to CD154.
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公开(公告)号：AU2011206587A1
公开(公告)日：2012-07-19
申请号：AU2011206587
申请日：2011-01-13
Applicant: UCB PHARMA SA
Inventor： ELLIS MARK , HUMPHREYS DAVID PAUL
IPC: C07K14/245 , C12N15/70
Abstract: The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell: a. comprises a recombinant polynucleotide encoding DsbC; and b. has reduced Tsp protein activity compared to a wild-type cell.
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