公开(公告)号：WO1997009644A1

公开(公告)日：1997-03-13

申请号：PCT/US1996014080

申请日：1996-09-03

Applicant: UNIVERSITY OF NEW MEXICO ,  BRUECK, Steven, R., J. ,  LONG, Xiang-Cun

Inventor： UNIVERSITY OF NEW MEXICO

IPC: G02B06/12

CPC classification number: G02F1/3558 ,  G02B6/02 ,  G02B6/02076 ,  G02B6/245 ,  G02B6/2843 ,  G02F1/065 ,  G02F1/225

Abstract: A low-cost fabrication technique, readily extensible to volume manufacturing is presented for an electro-optically active fiber segment (31) that can be simply integrated into optoelectronic devices. The fabrication technique offers a dielectric isolation structure (16, 17) surrounding the fiber (10) to allow high field poling, a pair of electrodes (37, 38) used both for poling and for inducing an electro-optic effect, and ends of the fiber (18, 19) unaffected by the fabrication and available for splicing with additional fiber sections. The technique is readily adaptable to specialized electrode structures including striplines and/or microstrip lines for high frequency applications and segmented electrodes (52) for quasi-phasematched three-wave mixing applications. By combining the electro-optically active fiber segment (31) with other fibers in an integrated fiber modulator, high frequency modulation of an optical signal may be achieved with applications in telecommunications. By including a Bragg grating structure (53, 54) in the same fiber segment, a remotely accessible electric field sensor is achieved. Three-wave mixing processes in the electro-optically active fiber segment (31) will allow the generation of additional coherent radiation sources in both the visible/UV and infrared spectral ranges.

Abstract translation: 对于可以简单地集成到光电子器件中的电光学有源光纤段（31），呈现容易制造的易于扩展的低成本制造技术。 制造技术提供围绕光纤（10）的介电隔离结构（16,17）以允许高场极化，一对电极（37,38）用于极化和诱导电光效应， 纤维（18,19）不受制造的影响并且可用于与额外的纤维部分拼接。 该技术易于适用于专用电极结构，包括用于高频应用的带状线和/或微带线以及用于准相位三波混频应用的分段电极（52）。 通过将电光活性光纤段（31）与集成光纤调制器中的其它光纤组合，可以在电信应用中实现光信号的高频调制。 通过在相同的光纤段中包括布拉格光栅结构（53,54），实现了可远程访问的电场传感器。 电光活性纤维段（31）中的三波混合过程将允许在可见/紫外和红外光谱范围内产生附加的相干辐射源。

公开(公告)号：WO1995027190A1

公开(公告)日：1995-10-12

申请号：PCT/US1995004269

申请日：1995-04-03

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  BRUECK, Steven, R., J. ,  BURCKEL, David, B. ,  FRAUENGLASS, Andrew ,  ZAIDI, Saleem

IPC: G01L01/24

CPC classification number: G01B11/162 ,  G01L1/24

Abstract: A displacement method and device in which speckle amplitude interferometry within a single speckle feature or a small number of features of a speckle pattern is used to achieve sub-fringe accuracy with a single detector and to measure displacement of the object (3) under investigation with sub-wavelength accuracy at measurement speeds consistent with real-time control of manufacturing processes. The same technique applied to multiple spots on a sample (3) with optical means for causing interference between different combinations of scattered fields, for example beams (4) and (14) interfere and beams (5) and (15) interfere, including fields (4 or 5 and 14 or 15) from different illumination spots, permits measurements of the total sample (3) motion.

Abstract translation: 使用位移方法和装置，其中使用单个斑点特征中的斑点幅度干涉测量或斑点图案的少量特征来实现单个检测器的子边缘精度，并且测量被研究物体（3）的位移。 测量速度下的亚波长精度与制造过程的实时控制一致。 相同的技术应用于具有光学装置的样品（3）上的多个点的相同技术，用于引起散射场的不同组合之间的干扰，例如光束（4）和（14）干涉和光束（5）和（15）干涉，包括场 （4或5和14或15）从不同的照明点，允许测量总样本（3）运动。

公开(公告)号：WO1995012674A1

公开(公告)日：1995-05-11

申请号：PCT/US1994012609

申请日：1994-11-02

Applicant: ZYMOGENETICS, INC. ,  UNIVERSITY OF NEW MEXICO

Inventor： ZYMOGENETICS, INC. ,  UNIVERSITY OF NEW MEXICO ,  SPRECHER, Cindy, A. ,  KISIEL, Walt ,  FOSTER, Donald, C.

IPC: C12N15/15

CPC classification number: C07K14/8114 ,  A61K38/00

Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

Abstract translation: 本发明提供了分离的DNA分子，其包含编码新型人Kunitz型抑制剂的DNA区段。 还提供了包含编码新型人Kunitz型抑制剂的第一DNA区段的DNA构建体，其中所述第一DNA区段与第一DNA区段的表达所需的另外的DNA区段可操作地连接，以及含有这种DNA构建体的宿主细胞， 从宿主细胞产生蛋白质的方法。

公开(公告)号：WO1995004753A1

公开(公告)日：1995-02-16

申请号：PCT/US1994008689

申请日：1994-08-04

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  ZAMORA, Paul ,  GRIFFITH, Jeffery, K.

IPC: C07K14/00

CPC classification number: A61K49/14 ,  A61K38/00 ,  A61K2123/00 ,  C07K14/825 ,  C07K2319/00 ,  C12N9/6459 ,  C12Y304/21069

Abstract: Components of the primary amino acid sequence of a metallothionein are genetically incorporated into proteins by recombinant DNA techniques to produce a hybrid molecule comprising an effector protein continuous with the metallothionein. The sulfhydryl and lysine residues of the metallothionein portion of the hybrid molecule provide binding sites for ligands such as radionuclides, contrast agents, magnetic resonance agents, fluorochromes, and enzymes. The labeled hybrid molecule is useful for the diagnosis and localization of disease lesions and is a cost-effective method of producing key ingredients for immunoassays including immunosorbant assay, immunoblot, immunodot, immunohistochemistry, and/or flow cytometry.

Abstract translation: 通过重组DNA技术将金属硫蛋白的一级氨基酸序列的成分遗传并入蛋白质中，以产生包含与金属硫蛋白连续的效应蛋白的杂交分子。 杂交分子的金属硫蛋白部分的巯基和赖氨酸残基为配体例如放射性核素，造影剂，磁共振剂，荧光染料和酶提供结合位点。 标记的杂交分子可用于疾病病变的诊断和定位，并且是生产关键成分的成本有效的方法，包括免疫吸附测定，免疫印迹，免疫印迹，免疫组织化学和/或流式细胞术。

公开(公告)号：WO1992019105A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003678

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  SCALLEN, Terence, J. ,  MANN, Paul, L.

IPC: A01N43/52

CPC classification number: A61K31/4045 ,  A61K31/405 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4172 ,  A61K31/4174 ,  Y02A50/402

Abstract: The invention provides cell modulators comprising certain biologically-active enantiomers of mevalonate and mevalonolactone derivatives. The compounds are broadly clinically usefull, particularly in cancer management and treatment of immunological diseases or disorders.

Abstract translation: 本发明提供了包含甲羟戊酸和甲羟戊酸内酯衍生物的某些生物活性对映异构体的细胞调节剂。 该化合物在临床上广泛使用，特别是在癌症治疗和免疫疾病或病症治疗方面。

公开(公告)号：WO1997009038A1

公开(公告)日：1997-03-13

申请号：PCT/US1996013506

申请日：1996-08-29

Applicant: UNIVERSITY OF NEW MEXICO ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： UNIVERSITY OF NEW MEXICO ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  ROSENBERG, Gary, A. ,  LIOTTA, Lance ,  STETLER-STEVENSON, William, G.

IPC: A61K31/00

CPC classification number: A61K38/57 ,  C12Q1/37 ,  G01N33/573 ,  G01N2333/96486

Abstract: The invention provides a method for the diagnosis and treatment of neurological diseases or disorders characterized by disruption of the blood/brain barrier. The 92 kDa zymogen of gelatinase B and active gelatinase B are markers of neuropathologies associated with disruption of the blood/brain barrier.

Abstract translation: 本发明提供了诊断和治疗以血/脑屏障破坏为特征的神经疾病或病症的方法。 明胶酶B和活性明胶酶B的92kDa酶原是与血液/脑屏障破坏相关的神经病理学标志物。

公开(公告)号：WO1995013013A1

公开(公告)日：1995-05-18

申请号：PCT/US1994013209

申请日：1994-11-09

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  WILKINS, Ebtisam, S.

IPC: A61B05/00

CPC classification number: A61B5/1486 ,  A61B5/14865 ,  C12Q1/005 ,  C12Q1/006 ,  Y10S435/817

Abstract: This invention is a reusable, miniature, implantable electrochemical sensor, a method of making the same, and a powder therefor that is provided. Enzyme material (53) is immobilized on bulk particulate matter, and a reaction chamber (23) of the sensor (10) is then filled therewith. The sensor (10) is implanted in an environment where it comes into contact with a specific component of a fluid with which the enzyme material chemically reacts to produce electrical signals for measuring the reaction.

Abstract translation: 本发明是可重复利用的微型植入式电化学传感器，其制造方法及其粉末。 将酶材料（53）固定在散装颗粒物质上，然后将传感器（10）的反应室（23）填充。 将传感器（10）植入到与酶材料发生化学反应的流体的特定部件接触以产生用于测量反应的电信号的环境中。

公开(公告)号：WO1994025149A1

公开(公告)日：1994-11-10

申请号：PCT/US1994005105

申请日：1994-04-28

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  DESHPANDE, Ravindra ,  SMITH, Douglas, M. ,  BRINKER, C., Jeffrey

IPC: B01J13/00

CPC classification number: B01J13/0091 ,  C01B33/163 ,  Y02P20/544 ,  Y10T428/2995

Abstract: This invention provides an extremely porous xerogel dried at vacuum to below-supercritical pressures but having the properties of aerogels which are typically dried at supercritical pressures. This is done by reacting the internal pore surface of the wet gel (e.g. alkoxide-derived silica gel) with an organic surface modification agent (e.g. trimethylchloro-silane in benzene) in order to change the contact angle of the fluid meniscus in the pores during drying. Shrinkage of the gel (which is normally prevented by the use of high autoclave pressures, such that the pore fluid is at temperature and pressure above its critical value) is avoided even at vacuum or ambient pressures. The figure 4 shows a change in sample weight and sample length during drying for surface modified, ambient pressure gel processed in accordance with the invention, illustrating the initial shrinkage followed by expansion of the gel during the final stages of drying. The extremely low density finely pored gel products have useful insulating and other properties.

Abstract translation: 本发明提供了一种在真空至低于超临界压力下干燥但具有通常在超临界压力下干燥的气凝胶的特性的极多孔干凝胶。 这通过使湿凝胶的内部孔表面（例如烷氧基衍生的硅胶）与有机表面改性剂（例如苯中的三甲基氯硅烷）反应，以便改变孔中的流体弯液面的接触角 烘干。 即使在真空或环境压力下，也避免了凝胶的收缩（通常通过使用高压釜压力来防止孔隙流体处于高于其临界值的温度和压力下）。 图4显示根据本发明处理的表面改性的环境压力凝胶的干燥期间样品重量和样品长度的变化，示出了在干燥的最后阶段期间凝胶的初始收缩率。 极低密度精细凝胶产品具有有用的绝缘和其他性能。

公开(公告)号：WO1994025031A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004063

申请日：1994-04-21

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  MONTNER, Paul ,  CHICK, Thomas, W. ,  STARK, Dan ,  RIEDESEL, Marvin, L.

IPC: A61K31/52

CPC classification number: A61K33/00 ,  A23L2/38 ,  A23L2/52 ,  A23L29/035 ,  A61K31/047 ,  A61K33/14 ,  Y10S426/81 ,  A61K31/7004 ,  A61K2300/00

Abstract: An exercise regimen which enhances exercise endurance and performance. The regimen includes pre-exercise hydration with a glycerol solution combined with hydration during exercise with a glycerol based solution to prolong hydration effects. The first pre-exercise glycerol solution regimen begins 2 hours prior to exercise and ends 1/2 hour before exercise begins. The hydration during exercise regimen combines glycerol with a carbohydrate and sodium to prolong fluid retention.

Abstract translation: 一种增强运动耐力和性能的运动方案。 该方案包括运动前水合与甘油溶液结合锻炼过程中的水合与甘油基溶液以延长水合作用。 第一次运动前甘油溶液方案在运动前2小时开始，并在运动开始前1/2小时结束。 运动方案中的水合将甘油与碳水化合物和钠结合以延长流体保留。

公开(公告)号：WO1992019239A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003666

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  MANN, Paul ,  MASH, Eugene

IPC: A61K31/44

CPC classification number: C07K14/37 ,  A01N1/0226 ,  A61K31/19 ,  A61K31/192 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/435 ,  A61K36/06 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/55594 ,  C12N2501/999

Abstract: Biomodulators, which regulates cellular differentiation and proliferation, as well as methods of use thereof, e.g., for treating various conditions, e.g., cancer, senescence, immunological disorders and vascular disease; for stimulating normal tissue architecture after injury; for vaccination; for stimulating the production of biologically important molecules by cells or organs in culture; for maintaining organs or tissues outside of a body after removal from the body and prior to transplantation; and for producing of vascular grafts for transplantation; are provided.

Abstract translation: 调节细胞分化和增殖的生物调节剂，以及其使用方法，例如用于治疗各种病症，例如癌症，衰老，免疫学疾病和血管疾病; 用于刺激损伤后的正常组织结构; 接种疫苗 用于刺激培养物中细胞或器官生物重要分子的生成; 用于在身体移除后和移植前将器官或组织保持在身体外部; 并用于生产用于移植的血管移植物; 被提供。