公开(公告)号：WO1992019240A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003672

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  MANN, Paul, L. ,  MASH, Eugene ,  SCALLEN, Terence, J.

IPC: A61K31/44

CPC classification number: A61K31/445 ,  A61K31/19 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4164 ,  A61K2039/55511 ,  A61K2039/55594 ,  C12N2501/999 ,  Y10S514/883

Abstract: Biomodulators, which regulate cellular differentiation and proliferation, as well as methods of use thereof, e.g., for treating various conditions, e.g., cancer, senescence, immunological disorders and vascular disease; for stimulating normal tissue architecture after injury; for vaccination; for stimulating the production of biologically important molecules by cells or organs in culture; for maintaining organs or tissues outside of a body after removal from the body and prior to transplantation; and for producing vascular grafts for transplantation; are provided.

Abstract translation: 调节细胞分化和增殖的生物调节剂，以及其使用方法，例如用于治疗各种病症，例如癌症，衰老，免疫学疾病和血管疾病; 用于刺激损伤后的正常组织结构; 接种疫苗 用于刺激培养物中细胞或器官生物重要分子的生成; 用于在身体移除后和移植前将器官或组织保持在身体外部; 并用于生产用于移植的血管移植物; 被提供。

公开(公告)号：WO1992019105A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003678

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  SCALLEN, Terence, J. ,  MANN, Paul, L.

IPC: A01N43/52

CPC classification number: A61K31/4045 ,  A61K31/405 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4172 ,  A61K31/4174 ,  Y02A50/402

Abstract: The invention provides cell modulators comprising certain biologically-active enantiomers of mevalonate and mevalonolactone derivatives. The compounds are broadly clinically usefull, particularly in cancer management and treatment of immunological diseases or disorders.

Abstract translation: 本发明提供了包含甲羟戊酸和甲羟戊酸内酯衍生物的某些生物活性对映异构体的细胞调节剂。 该化合物在临床上广泛使用，特别是在癌症治疗和免疫疾病或病症治疗方面。

公开(公告)号：EP0675715B1

公开(公告)日：2002-08-21

申请号：EP92912191.1

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： SCALLEN, Terence, J. ,  MANN, Paul, L.

IPC: A61K31/415 ,  A61K31/19 ,  A61K31/395

CPC classification number: A61K31/4045 ,  A61K31/405 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4172 ,  A61K31/4174 ,  Y02A50/402

Abstract: The invention discloses that certain biologically-active enantiomers of mevalonate and mevalonolactone derivatives are cell modulator compounds. The compounds are clinically useful for treating disorders characterised by either diminished cellular function or aberrant cellular function, particularly in cancer management and treatment of immunological diseases or disorders, like AIDS, infections diseases, diabetes, multiple sclerosis, lupus erythematosus, rheumataroid arthritis, artherosclerosis.

公开(公告)号：EP0675715A1

公开(公告)日：1995-10-11

申请号：EP92912191.0

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： SCALLEN, Terence, J. ,  MANN, Paul, L.

IPC: C07D233 ,  A61K31 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07C69 ,  C07D207 ,  C07D209 ,  C07D215 ,  C07D231 ,  C07D309 ,  C07D405 ,  C07D471

CPC classification number: A61K31/4045 ,  A61K31/405 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4172 ,  A61K31/4174 ,  Y02A50/402

Abstract: The invention discloses that certain biologically-active enantiomers of mevalonate and mevalonolactone derivatives are cell modulator compounds. The compounds are clinically useful for treating disorders characterised by either diminished cellular function or aberrant cellular function, particularly in cancer management and treatment of immunological diseases or disorders, like AIDS, infections diseases, diabetes, multiple sclerosis, lupus erythematosus, rheumataroid arthritis, artherosclerosis.

Abstract translation: 本发明提供了包含甲羟戊酸和甲羟戊酸内酯衍生物的某些生物活性对映异构体的细胞调节剂。 这些化合物在临床上广泛使用，特别是在癌症治疗和免疫性疾病或病症的治疗中。