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    DRUG CONTAINING MATRIX
    22.
    发明申请
    DRUG CONTAINING MATRIX 审中-公开
    含有药物基质

    公开(公告)号：WO1991003234A1

    公开(公告)日：1991-03-21

    申请号：PCT/US1989003802

    申请日：1989-09-05

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

    Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  STANLEY, Theodore, H. ,  HAGUE, Brian

    IPC: A61K09/20

    CPC classification number: A23G3/368 ,  A61K9/0056 ,  A61K31/465 ,  Y10S426/801 ,  Y10S514/948

    Abstract: The present invention is directed to methods and compositions for noninvasively administering drugs in a dose-to-effect manner to produce a cardiovascular or renal vascular activity. A cardiovascular or renal vascular drug, which is capable of absorption through mucosal tissues of the mouth, pharynx, and esophagus is incorporated into a matrix which is in the form of a lollipop. A patient is put at ease when given the lollipop, and the drug rapidly enters the patient's bloodstream as the lollipop is sucked. When treating the patient, the physician can observe the patient's condition and remove the lollipop when it has had a desired effect on the patient. A lollipop into which a cardiovascular or renal vascular drug has been dispersed is particularly useful for achieving rapid vasodilating, calcium channel blocking, beta-blocking, seritonin receptor blocking, angina blocking, anti-hypertensive, and cardiac stimulating effects and for controlling urine output.

    Abstract translation: 镇静剂，止痛剂或麻醉剂。 包括：有效剂量的有效剂量（I），能够通过粘膜组织吸收，均匀分散在溶解在口腔释放（I）中的可溶性基质（II）中，以及固定在药物接触物上的保持剂。 基体构造成当获得期望的条件时允许插入和从口中移除。 compsn。 尤其是 以棒棒糖的形式。

    USE OF 'alpha'-CONOTOXIN MII TO TREAT DISORDERS RESULTING FROM NICOTINE-STIMULATED DOPAMINE RELEASE
    23.
    发明申请
    USE OF 'alpha'-CONOTOXIN MII TO TREAT DISORDERS RESULTING FROM NICOTINE-STIMULATED DOPAMINE RELEASE 审中-公开
    使用阿托毒素MII治疗由尼古丁刺激的多巴胺释放引起的疾病

    公开(公告)号：WO1998024462A1

    公开(公告)日：1998-06-11

    申请号：PCT/US1997022350

    申请日：1997-12-05

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

    Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  McINTOSH, J., Michael ,  KULAK, Jennifer, M. ,  YOSHIKAMI, Doju ,  OLIVERA, Baldomero, M.

    IPC: A61K38/00

    CPC classification number: A61K38/1767 ,  Y10S514/813

    Abstract: Neuronal nicotinic acetylcholine receptors (nAChRs) are believed to mediate nicotine addiction. In addition, stimulation of nAChRs modulates release of neurotransmitters including dopamine, norepinephrine and serotonin. Thus, pharmacological manipulation of nicotinic receptors has implications for a wide variety of disorders including psychotic, mood, movement and cognitive. For most nAChRs, there are no subtype selective ligands. However, alpha -conotoxin MII, a small peptide from the carnivorous marine snail Conus magus, was recently isolated. This peptide has been shown o be a specific antagonist for alpha 3 beta 2 nicotinic receptors. The peptide potently blocks part, but not all, of nicotine-stimulated dopamine release from rat brain striatal synaptosomes. In contrast it has no effect on potassium stimulated dopamine release. Other alpha -conotoxins specifically target distinct neuronal nAChR subtypes. alpha -Conotoxins thus represent new lead compounds for CNS disorders.

    Abstract translation: 神经元烟碱乙酰胆碱受体（nAChRs）被认为是介导尼古丁成瘾。 另外，刺激nAChR调节神经递质的释放，包括多巴胺，去甲肾上腺素和5-羟色胺。 因此，烟碱受体的药理学操作对各种各样的障碍有影响，包括精神病，情绪，运动和认知。 对于大多数nAChR，没有亚型选择性配体。 然而，α-毒素MII，一种来自肉食海洋蜗牛Conus magus的小肽，最近被隔离。 已经显示该肽是α3β2烟碱受体的特异性拮抗剂。 该肽有效地阻止了大鼠脑纹状体突触体中尼古丁刺激的多巴胺释放的部分，但并非全部。 相比之下，它对钾刺激的多巴胺释放没有影响。 其他α-毒素特异性靶向不同的神经元nAChR亚型。 因此，α-核酸毒素代表CNS疾病的新型铅化合物。

    COMPOSITIONS AND METHODS FOR RAPID ISOLATION OF PLASMID DNA
    24.
    发明申请
    COMPOSITIONS AND METHODS FOR RAPID ISOLATION OF PLASMID DNA 审中-公开
    用于快速分离PLASMID DNA的组合物和方法

    公开(公告)号：WO1998016653A1

    公开(公告)日：1998-04-23

    申请号：PCT/US1997018762

    申请日：1997-10-15

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  CHEN, Zhidong ,  RUFFNER, Duane

    Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION

    IPC: C12P19/34

    CPC classification number: C12N1/06 ,  C12N15/1003

    Abstract: A composition for isolating plasmid DNA from a bacterial culture is disclosed, the composition containing at least about 3 M magnesium chloride and about 10 % (w/v) polyethylene glycol. A method of differentially precipitating plasmid DNA from a bacterial lysate is also disclosed, involving the steps of lysing bacterial cells to obtain a bacterial lysate; mixing magnesium chloride and polyethylene chloride with the lysate to form a mixture containing at least about 1 M magnesium chloride and about 3.3 % (w/v) polyethylene glycol, thereby precipitating cellular debris, chromosomal DNA, cellular RNA, and proteins; separating and removing the precipitated material to form a cleared lysate; mixing magnesium chloride and polyethylene glycol with the cleared lysate to form a mixture containing at least about 1.5 M magnesium chloride and about 5 % (w/v) polyethylene chloride, thereby precipitating plasmid DNA; and separating the precipitated plasmid DNA from the mixture, thereby obtaining isolated plasmid DNA. Another composition according to the invention contains an enzyme for digestion of cellular RNA, a stabilizer for protecting plasmid DNA from nuclease digestion, and a precipitating agent for precipitating plasmid DNA. Another method of isolating plasmid DNA from a bacterial culture comprises simultaneously digesting cellular RNA in a clarified lysate with an enzyme, protecting plasmid DNA from nuclease digestion, and precipitating plasmid DNA.

    Abstract translation: 公开了一种用于从细菌培养物分离质粒DNA的组合物，该组合物含有至少约3M的氯化镁和约10％（w / v）的聚乙二醇。 还公开了从细菌裂解物差异沉淀质粒DNA的方法，其涉及裂解细菌细胞以获得细菌裂解物的步骤; 将氯化镁和聚氯乙烯与裂解物混合以形成含有至少约1M氯化镁和约3.3％（w / v）聚乙二醇的混合物，从而沉淀细胞碎片，染色体DNA，细胞RNA和蛋白质; 分离和除去沉淀的材料以形成澄清的裂解物; 将氯化镁和聚乙二醇与澄清的裂解物混合以形成含有至少约1.5M氯化镁和约5％（w / v）聚氯乙烯的混合物，从而沉淀质粒DNA; 并从混合物中分离沉淀的质粒DNA，从而获得分离的质粒DNA。 根据本发明的另一种组合物含有用于消化细胞RNA的酶，用于保护质粒DNA免于核酸酶消化的稳定剂和用于沉淀质粒DNA的沉淀剂。 从细菌培养物分离质粒DNA的另一种方法包括用酶消化澄清的裂解物中的细胞RNA，保护质粒DNA免于核酸酶消化，并沉淀质粒DNA。

    METHOD AND APPARATUS FOR ANALYSIS OF CHROMATOGRAPHIC MIGRATION PATTERNS
    25.
    发明申请
    METHOD AND APPARATUS FOR ANALYSIS OF CHROMATOGRAPHIC MIGRATION PATTERNS 审中-公开
    色谱迁移模式分析方法与装置

    公开(公告)号：WO1998011258A1

    公开(公告)日：1998-03-19

    申请号：PCT/US1997016933

    申请日：1997-09-16

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  MARKS, Andy, F.

    Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION

    IPC: C12Q01/68

    CPC classification number: G01N27/447 ,  C12Q1/6869

    Abstract: The present invention includes a method and apparatus for the detection and analysis of information-containing signals in chromatographic data using iterative blind deconvolution and fuzzy logic algorithms. The invented method analyzes chromatographic data from a wide variety of sources of DNA sequencing information, including gel and capillary electrophoresis. Autoradiograms, single-fluor, four-lane and four fluor, single lane fluorescent chromatographic data are suitable sources of unprocessed input data. The output from the invented base calling method includes called (identified) sequence data and quality values for the called bases.

    Abstract translation: 本发明包括使用迭代盲解卷积和模糊逻辑算法在色谱数据中检测和分析含信息信号的方法和装置。 本发明的方法分析了来自各种DNA测序信息的色谱数据，包括凝胶和毛细管电泳。 放射自显影，单荧光，四通道和四氟单道荧光色谱数据是未经处理的输入数据的合适来源。 来自本发明的基本呼叫方法的输出包括被叫（识别）的序列数据和被叫基的质量值。

    MARKING PEN FOR COLORING THE SKIN
    28.
    发明申请
    MARKING PEN FOR COLORING THE SKIN 审中-公开
    标记笔用于染色皮肤

    公开(公告)号：WO1997003612A1

    公开(公告)日：1997-02-06

    申请号：PCT/US1996012023

    申请日：1996-07-19

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

    Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  CHASAN, Paul, E.

    IPC: A61B17/00

    CPC classification number: A61B90/39 ,  A61B2090/395

    Abstract: An apparatus (2) and method are disclosed for marking the proper location of incisions to be made during a surgical procedure, and for coloring the skin. The apparatus (2) includes a pinwheel (16) with a plurality of marking points (18) extending therefrom for penetrating the outermost layer of the epidermis. A reservoir (6) supplies a marking agent so that as the penetrating member (18) penetrates the epidermis, a marking agent is left within the epidermis, thereby leaving a dotted line which may be followed when making incisions during surgery. The method includes penetrating the outermost layer of the epidermis, leaving a marking agent between the outermost layer of the epidermis and an innermost layer of the epidermis.

    Abstract translation: 公开了一种设备（2）和方法，用于标记在外科手术过程中要进行的切口的适当位置，并使皮肤着色。 装置（2）包括具有从其延伸的多个标记点（18）的风车（16），用于穿透表皮的最外层。 储存器（6）供应标记剂，使得当穿透构件（18）穿透表皮时，标记剂留在表皮内，从而留下在手术期间进行切口时可以遵循的虚线。 该方法包括穿透表皮的最外层，在表皮的最外层和表皮的最内层之间留下标记剂。

    METHOD FOR COAL LIQUEFACTION
    30.
    发明申请
    METHOD FOR COAL LIQUEFACTION 审中-公开
    煤液化方法

    公开(公告)号：WO1995029969A1

    公开(公告)日：1995-11-09

    申请号：PCT/US1995004945

    申请日：1995-05-02

    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

    Inventor： UNIVERSITY OF UTAH RESEARCH FOUNDATION ,  WISER, Wendell, H. ,  OBLAD, Alex, G. ,  SHABTAI, Joseph, S.

    IPC: C10G01/00

    CPC classification number: C10G1/08

    Abstract: A process is disclosed for coal liquefaction in which minute particles of coal in intimate contact with a hydrogenation catalyst and hydrogen are reacted for a very short time at a temperature in excess of 400 DEG C at a pressure of at least 1,700 kilonewtons per square meter (250 psi) to yield over 50 % liquids with a liquid to gaseous hydrocarbon ratio in excess of 8:1.

    Abstract translation: 公开了一种用于煤液化的方法，其中与氢化催化剂和氢气紧密接触的煤的微小颗粒在至少1700千牛顿每平方米的压力下在超过400℃的温度下反应非常短的时间（ 250psi），以产生超过50％液体与气体烃比超过8:1的液体。

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