公开(公告)号：SE417097B

公开(公告)日：1981-02-23

申请号：SE7503993

申请日：1975-04-08

Applicant: WELLCOME FOUND

Inventor： ROTH B

IPC: C07D239/48 ,  C07D239/49

Abstract: Improvements made to the subject of main patent No. 336,945 granted on October 17, 1967 for "A method of preparing 5-benzyl-pyrimidines" according to which the preparation of a 2,4-diamino-5-benzylpyrimidine of general formula **(See formula)** in which R1, R2, R4 and R5 are the same or different and each of them is a hydrogen atom, a halogen atom, an alcohol group or an alkoxy group, each containing the alkoxy and alcohol groups from 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms, and in which R3 is a saturated or unsaturated hydrocarbon radical containing up to 12 carbon atoms, which, optionally, is substituted by a halogen atom, for example chlorine, the method comprises reducing, by hydrogenolysis of the SR6 group, a compound of the formula: **(See formula)** in which R3'is R3 or a hydrogen atom and in which R6 is an alcohol group having 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms carbon, or an aralkoxy group such as benzyl and, in the event that R3'is hydrogen, react the hydroxyl group of the pyrimidine from which the thio group has been removed with a compound of formula R3Q where Q is an atom or reactive group. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：SE405118B

公开(公告)日：1978-11-20

申请号：SE484872

申请日：1972-04-14

Applicant: WELLCOME FOUND

Inventor： ROTH B

IPC: C07D239/48 ,  C07D239/49

Abstract: Improvements made to the subject of main patent No. 336,945 granted on October 17, 1967 for "A method of preparing 5-benzyl-pyrimidines" according to which the preparation of a 2,4-diamino-5-benzylpyrimidine of general formula **(See formula)** in which R1, R2, R4 and R5 are the same or different and each of them is a hydrogen atom, a halogen atom, an alcohol group or an alkoxy group, each containing the alkoxy and alcohol groups from 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms, and in which R3 is a saturated or unsaturated hydrocarbon radical containing up to 12 carbon atoms, which, optionally, is substituted by a halogen atom, for example chlorine, the method comprises reducing, by hydrogenolysis of the SR6 group, a compound of the formula: **(See formula)** in which R3'is R3 or a hydrogen atom and in which R6 is an alcohol group having 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms carbon, or an aralkoxy group such as benzyl and, in the event that R3'is hydrogen, react the hydroxyl group of the pyrimidine from which the thio group has been removed with a compound of formula R3Q where Q is an atom or reactive group. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：SE391180B

公开(公告)日：1977-02-07

申请号：SE484772

申请日：1972-04-14

Applicant: WELLCOME FOUND

Inventor： ROTH B

IPC: A61K31/505 ,  A61P31/04 ,  A61P33/02 ,  C07C45/41 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/49

公开(公告)号：NO134837C

公开(公告)日：1976-12-21

申请号：NO391071

申请日：1971-10-21

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: A61K31/00 ,  A61K31/505 ,  C07D239/00 ,  C07D239/48

公开(公告)号：DK132221C

公开(公告)日：1976-04-20

申请号：DK184272

申请日：1972-04-14

Applicant: WELLCOME FOUND

Inventor： ROTH B

IPC: C07D239/48 ,  C07D239/49

Abstract: Improvements made to the subject of main patent No. 336,945 granted on October 17, 1967 for "A method of preparing 5-benzyl-pyrimidines" according to which the preparation of a 2,4-diamino-5-benzylpyrimidine of general formula **(See formula)** in which R1, R2, R4 and R5 are the same or different and each of them is a hydrogen atom, a halogen atom, an alcohol group or an alkoxy group, each containing the alkoxy and alcohol groups from 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms, and in which R3 is a saturated or unsaturated hydrocarbon radical containing up to 12 carbon atoms, which, optionally, is substituted by a halogen atom, for example chlorine, the method comprises reducing, by hydrogenolysis of the SR6 group, a compound of the formula: **(See formula)** in which R3'is R3 or a hydrogen atom and in which R6 is an alcohol group having 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms carbon, or an aralkoxy group such as benzyl and, in the event that R3'is hydrogen, react the hydroxyl group of the pyrimidine from which the thio group has been removed with a compound of formula R3Q where Q is an atom or reactive group. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：NO762090L

公开(公告)日：1972-10-17

申请号：NO762090

申请日：1976-06-16

Applicant: WELLCOME FOUND

Inventor： ROTH B

IPC: C07D20060101 ,  C07D239/48 ,  C07D

公开(公告)号：DK120549B

公开(公告)日：1971-06-14

申请号：DK21765

申请日：1965-01-15

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  HITCHINGS G

IPC: A61K31/53 ,  C07D251/10 ,  C07D55/20

公开(公告)号：YU186678A

公开(公告)日：1982-10-31

申请号：YU186678

申请日：1978-08-01

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  STUART A ,  PATERSON T

IPC: A61K31/00 ,  A61K31/505 ,  C07D239/00 ,  C07D239/48

公开(公告)号：NO136046B

公开(公告)日：1977-04-04

申请号：NO131172

申请日：1972-04-14

Applicant: WELLCOME FOUND

Inventor： ROTH B

IPC: C07D239/48 ,  C07D239/49

Abstract: Improvements made to the subject of main patent No. 336,945 granted on October 17, 1967 for "A method of preparing 5-benzyl-pyrimidines" according to which the preparation of a 2,4-diamino-5-benzylpyrimidine of general formula **(See formula)** in which R1, R2, R4 and R5 are the same or different and each of them is a hydrogen atom, a halogen atom, an alcohol group or an alkoxy group, each containing the alkoxy and alcohol groups from 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms, and in which R3 is a saturated or unsaturated hydrocarbon radical containing up to 12 carbon atoms, which, optionally, is substituted by a halogen atom, for example chlorine, the method comprises reducing, by hydrogenolysis of the SR6 group, a compound of the formula: **(See formula)** in which R3'is R3 or a hydrogen atom and in which R6 is an alcohol group having 1 to 12 carbon atoms, preferably 1 to 7 carbon atoms, and most preferably 1 to 4 carbon atoms carbon, or an aralkoxy group such as benzyl and, in the event that R3'is hydrogen, react the hydroxyl group of the pyrimidine from which the thio group has been removed with a compound of formula R3Q where Q is an atom or reactive group. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：DK133243C

公开(公告)日：1976-09-20

申请号：DK6174

申请日：1974-01-04

Applicant: WELLCOME FOUND

Inventor： ROTH B

IPC: C07D239/48