公开(公告)号：BR5908992D0

公开(公告)日：1973-05-24

申请号：BR10899259

申请日：1959-03-10

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  ELION G

IPC: C07D473/24 ,  C07D473/38

公开(公告)号：SE305875B

公开(公告)日：1968-11-11

申请号：SE227964

申请日：1964-02-25

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  ELION G

IPC: C07D239/60 ,  C07D401/12 ,  C07D51/30

公开(公告)号：NO119838B

公开(公告)日：1970-07-13

申请号：NO16110265

申请日：1965-12-31

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  URLBERT B

IPC: A61K31/00 ,  C07D471/04

公开(公告)号：DK116444B

公开(公告)日：1970-01-12

申请号：DK7566

申请日：1966-01-06

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  HURLBERT B

IPC: A61K31/00 ,  C07D471/04 ,  C07D57/20

公开(公告)号：ZA7501650B

公开(公告)日：1976-10-27

申请号：ZA7501650

申请日：1975-03-17

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  DE MIRANDA P ,  ELION G ,  SCHAEFFER H

IPC: C07D239/48 ,  C07D475/06 ,  C07H19/16 ,  C07C ,  A61K

CPC classification number: C07D475/06 ,  C07D239/48 ,  C07H19/16

公开(公告)号：SE317683B

公开(公告)日：1969-11-24

申请号：SE58365

申请日：1965-01-16

Applicant: WELLCOME FOUND

Inventor： ROTH B ,  HITCHINGS G

IPC: A61K31/53 ,  C07D251/10 ,  C07D55/14

公开(公告)号：DK114487B

公开(公告)日：1969-07-07

申请号：DK321162

申请日：1962-07-18

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  HURLBERT S

IPC: C07D471/04 ,  C07D57/20

公开(公告)号：ZA7401882B

公开(公告)日：1975-11-26

申请号：ZA7401882

申请日：1974-03-22

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  SIMMONS W ,  NICHOL C ,  ELION G ,  STICKNEY D

IPC: A61K31/505 ,  A61K27/00

CPC classification number: A61K31/505

公开(公告)号：DK117567B

公开(公告)日：1970-05-11

申请号：DK5165

申请日：1965-01-07

Applicant: WELLCOME FOUND

Inventor： HURLBERT B ,  HITCHINGS G

IPC: C07D471/04 ,  C07D57/20

Abstract: 1,084,103. 2,4 - Diamino - pyrido - [2,3 - d]- pyrimidines. WELLCOME FOUNDATION Ltd. Oct. 29, 1964 [Oct. 30, 1963], No. 44153/64. Heading C2C. The invention comprises compounds of the formula wherein R 1 represents a C 1-4 alkyl group, R 2 represents a benzyl group, unsubstituted or substituted by one or more halogen atoms, C 1-4 alkyl or C 1-4 alkoxy groups, and the preparation thereof by dethiolating the corresponding 7-mercapto derivative in the presence of Raney nickel. 7 - Mercapto - 2,4 - diamino - pyrido - [2,3-d]- pyrimidines corresponding to the Formula (I) may be prepared by the action of phosphorus pentasulphide on the corresponding 7-hydroxy derivative, or by the process of Specification 1,088,102. Therapeutic compositions with activity against gram-negative and gram-positive organisms, in the form of tablets, cachets, capsules, powders, granules, solutions, suspensions, emulsions, ointments and suppositories for oral, parenteral and topical application, comprise compounds of the Formula (I) together with a pharmaceutically acceptable carrier.

公开(公告)号：DK115852B

公开(公告)日：1969-11-17

申请号：DK399763

申请日：1963-08-21

Applicant: WELLCOME FOUND

Inventor： HITCHINGS G ,  ELION G

IPC: C07D57/28