SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD

    公开(公告)号:US20240210319A1

    公开(公告)日:2024-06-27

    申请号:US18382177

    申请日:2023-10-20

    Inventor: Satoshi YAMAMOTO

    CPC classification number: G01N21/6456 G01N2201/11 G01N2201/127

    Abstract: In a sample observation device, an image capturing unit includes an area image sensor that performs image capturing by the rolling shutter method in which a start of an exposure period of pixel columns in the pixel region is shifted by predetermined time, and a control unit controls the image capturing unit so that an exposure order in each of the pixel columns is reversed between a period in which a scanning unit scans a sample in a first direction and a period in which the scanning unit scans the sample in a second direction.

    SPECTROSCOPY APPARATUS AND METHODS
    22.
    发明申请
    SPECTROSCOPY APPARATUS AND METHODS 审中-公开
    光谱仪器和方法

    公开(公告)号:US20160238533A1

    公开(公告)日:2016-08-18

    申请号:US15025464

    申请日:2014-09-30

    Applicant: RENISHAW PLC

    Abstract: This invention concerns spectroscopy apparatus comprising a light source arranged to generate a light profile on a sample, a photodetector having at least one photodetector element for detecting characteristic light generated from interaction of the sample with light from the light source, a support for supporting the sample, the support movable relative to the light profile, and a processing unit. The processing unit is arranged to associate a spectral value recorded by the photodetector element at a particular time with a point on the sample predicted to have generated the characteristic light recorded by the photodetector element at the particular time based on relative motion anticipated to have occurred between the support and the light profile.

    Abstract translation: 本发明涉及光谱装置,其包括被配置为在样品上产生光分布的光源,具有至少一个光电探测元件的光电检测器,该光电检测元件用于检测由样品与来自光源的光的相互作用产生的特征光;支撑样品 ,相对于光轮廓可移动的支撑件,以及处理单元。 处理单元被布置为将由特定时间的光电检测器元件记录的光谱值与预测的样品上的点相关联,以在特定时间基于由光电检测器元件记录的特征光,基于预期发生在 支持和光线。

    DATA ACQUISITION METHOD USING A LASER SCANNER
    24.
    发明申请
    DATA ACQUISITION METHOD USING A LASER SCANNER 有权
    使用激光扫描仪的数据采集方法

    公开(公告)号:US20110006219A1

    公开(公告)日:2011-01-13

    申请号:US12666035

    申请日:2009-02-13

    Abstract: The invention relates to a data acquisition method using a laser scanner for the pixel-precise imaging of fluorescent samples which are on object carriers and have been treated with fluorescent dyes. Such a laser scanner comprises a sample table; at least one laser and a first optical system for providing at least one laser beam for exciting the fluorescent samples; a scanner head (50) having an optical deflecting element for scanning this sample in at least one direction of movement (75); a first lens; a second optical system for forwarding emission beams, which are triggered by the laser beams on the sample and are deflected by the first lens and the deflecting element, to at least one detector; a position encoder (91) which emits position encoder signals (92) which indicate the instantaneous location of the scanner head (50) in relation to a zero point; an electronic element for filtering the detector signals (93) with a defined time constant; and an A/D converter for digitizing the filtered detector signals (93). The data acquisition method according to the invention is characterized in that the filtered detector signals (93) from the A/D converter and the position encoder signals (92) are acquired independently, in a parallel manner and continuously by a computer unit or a controller (40) and are related to a common time base (94), wherein the A/D conversion is carried out so often that each pixel (95) of an image is always assigned more than one data point of the A/D converter.

    Abstract translation: 本发明涉及一种使用激光扫描仪进行像素精确成像的数据采集方法,其中荧光样品位于物体载体上并用荧光染料处理。 这种激光扫描器包括样品台; 至少一个激光器和第一光学系统,用于提供用于激发荧光样品的至少一个激光束; 扫描头(50)具有用于在至少一个运动方向(75)扫描该样品的光学偏转元件; 第一个镜头; 用于转发发射光束的第二光学系统,其由样品上的激光束触发并被第一透镜和偏转元件偏转到至少一个检测器; 位置编码器(91),其发射指示扫描器头(50)相对于零点的瞬时位置的位置编码器信号(92) 用于以确定的时间常数对检测器信号(93)进行滤波的电子元件; 以及用于数字化滤波的检测器信号(93)的A / D转换器。 根据本发明的数据获取方法的特征在于,来自A / D转换器的滤波检测器信号(93)和位置编码器信号(92)以并行方式独立地获取并且由计算机单元或控制器 (40)并且与公共时基(94)相关,其中所述A / D转换经常被执行,使得图像的每个像素(95)总是被分配多个A / D转换器的一个数据点。

    A SYSTEM AND METHOD FOR INDUCING AND DETECTING MULTI-PHOTON PROCESSES IN A SAMPLE
    27.
    发明公开
    A SYSTEM AND METHOD FOR INDUCING AND DETECTING MULTI-PHOTON PROCESSES IN A SAMPLE 审中-公开
    系统在VERFAHREN ZUM INDUZIEREN UND NACHWEISEN VON MULTIPHOTONPROZESSEN IN EINER PROBE

    公开(公告)号:EP3152806A1

    公开(公告)日:2017-04-12

    申请号:EP15726608.1

    申请日:2015-06-03

    Abstract: Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

    Abstract translation: 描述了用于诱导和检测多光子过程,特别是样品中的多光子荧光或更高次谐波产生的系统。 该系统包括动态可控光源,所述动态可控光源包括第一子光源,所述第一子光源是电可控制的,以便产生具有第一波长的光的可控时间依赖强度图案, 和至少一个光放大器,从而允许对多光子激发的产生的主动时间控制。 该系统还包括用于将由所述动态可控光源产生的光传送到采样点的光束传送单元,以及用于检测指示所述多光子过程,特别是多光子荧光信号的信号的检测器单元或检测器组件, 高次谐波信号。

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