公开(公告)号：US09921197B2

公开(公告)日：2018-03-20

申请号：US15042091

申请日：2016-02-11

Applicant: Jiade Yu

Inventor： Jiade Yu

IPC: G01N30/78 ,  G01N21/64 ,  G01N30/74 ,  G01N21/33 ,  G01N30/02

CPC classification number: G01N30/78 ,  G01N21/33 ,  G01N21/645 ,  G01N30/74 ,  G01N2021/6417 ,  G01N2030/027 ,  G01N2201/068 ,  G01N2201/124

Abstract: A both ultraviolet-visible and double monochromatic fluorescence dual detector has a small inner-casing, which combines both ultraviolet-visible and double monochromatic fluorescence dual detector widely used in the high performance liquid chromatography by taking the first to use deuterium lamp as the individual light source of the dual detectors, the individual sample detection cell and the individual electrical circuit, the device comprises a detection optical member, which including a first monochromatic spectroscopic device—raster G1, a second monochromatic spectroscopic device—raster G2, a light source, four groups of lens needed for processing the light paths; and a detection electromechanical member, which includes: a central controller, a proposed amplifying module, an auto gain module, a noise processing module and a logarithm amplifying module. The dual detector realizes the sensitivity and stability, also the elimination of noise and drift.

公开(公告)号：US20150268165A1

公开(公告)日：2015-09-24

申请号：US14644717

申请日：2015-03-11

Applicant: KONICA MINOLTA, INC.

Inventor： Keita SAITO ,  Midori SHIMOMURA ,  Dai SUWAMA ,  Sayaka MORITA

IPC: G01N21/49 ,  G01N21/55

CPC classification number: G01N21/49 ,  G01N21/55 ,  G01N2201/06146 ,  G01N2201/124

Abstract: A processing apparatus includes: a light emission unit configured to emit light to a surface of a particle dispersed liquid applied to a base material, the particle dispersed liquid having particles dispersed in a solvent; a reflected light amount monitoring unit configured to detect an amount of the light reflected, and monitor a temporal variation of the detected value; and a condition adjustment unit configured to adjust a condition for a particle securing process, the particle securing process being performed to remove the solvent and secure the particles onto the base material, wherein, when the temporal variation falls within a predetermined range after the value has reached an extreme value, securing of the particles is determined to have been completed.

Abstract translation: 一种处理装置包括：发光单元，被配置为向施加到基材的颗粒分散液体的表面发光，所述颗粒分散液体具有分散在溶剂中的颗粒; 反射光量监视单元，被配置为检测反射的光量，并监视检测值的时间变化; 以及条件调整单元，被配置为调整用于颗粒固定过程的条件，进行所述颗粒固定处理以除去溶剂并将颗粒固定在基材上，其中，当所述时间变化落在所述值具有 达到极限值，确定颗粒的确定已经完成。

公开(公告)号：US07821637B1

公开(公告)日：2010-10-26

申请号：US12070824

申请日：2008-02-21

Applicant: Galen L. Pfeiffer ,  Martin M. Liphardt ,  James N. Hilfiker

Inventor： Galen L. Pfeiffer ,  Martin M. Liphardt ,  James N. Hilfiker

IPC: G01J4/00

CPC classification number: G01N21/211 ,  G01N2201/124

Abstract: Disclosed is a system for controlling focus, angle of incidence and intensity of an electromagnetic beam over a spectrum of wavelengths, and methodology for optimizing investigation of samples which demonstrate low specular reflectance and/or are depolarizing of a polarized beam of electromagnetic radiation, such as solar cells.

Abstract translation: 公开了一种用于控制波长范围内的电磁束的聚焦，入射角和强度的系统，以及用于优化对具有低镜面反射率和/或正电极的偏振光束的去极化的样品的优化研究的方法，例如 太阳能电池。

公开(公告)号：US20060060759A1

公开(公告)日：2006-03-23

申请号：US10944807

申请日：2004-09-21

Applicant: Joe Predina ,  Frederick Williams

Inventor： Joe Predina ,  Frederick Williams

IPC: H01J3/14 ,  G01J1/42 ,  G01J1/00

CPC classification number: G01J5/522 ,  G01J1/08 ,  G01J3/4535 ,  G01N2201/124

Abstract: A system for measuring optical detector linearity according to the present invention employs a laser source that illuminates an integrating sphere. The sphere randomizes the laser signal phase and produces a uniform intensity over the sphere output. A collimator expands the sphere output for entry into an interferometer, where the incident optical energy is amplitude modulated in a sinusoidal fashion by a linear mechanical mirror movement. Optical band filters eliminate significant harmonic content being present on a pre-detected optical signal. Sampling of the detected signal energy is performed synchronous to the mechanical mirror position to assure sinusoidal response. The sampled signals are processed to separately determine signal harmonic components attributed to detector non-linearity and multiple laser reflections within the system. The system utilizes at least two measurements at two different laser intensities. An optional third measurement of background radiance may be applied to the first two measurements to enhance accuracy.

公开(公告)号：WO2010044003A3

公开(公告)日：2010-06-10

申请号：PCT/IB2009054365

申请日：2009-10-06

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  VAN BEEK MICHAEL C ,  RENSEN WOUTER H J ,  HARBERS RIK

Inventor： VAN BEEK MICHAEL C ,  RENSEN WOUTER H J ,  HARBERS RIK

IPC: G01N21/47 ,  A61B5/00 ,  G01N21/49 ,  G01N21/59

CPC classification number: A61B5/0059 ,  A61B5/4528 ,  G01N21/4795 ,  G01N2201/0626 ,  G01N2201/0635 ,  G01N2201/0675 ,  G01N2201/124

Abstract: A device (1; 10; 20; 30; 40) for optically examining the interior of a turbid medium (5) is provided. The device comprises an illumination system (2; 12; 22; 32; 42) adapted for illuminating a turbid medium (5) to be examined and an imaging device (106) adapted for generating images from detected light. The illumination system (2; 12; 22; 32; 42) is adapted to be operable in at least a first mode in which a wide area image is acquired by illuminating the turbid medium (5) and a surrounding area. From this wide area image, the region or regions of interest (110) at which the turbid medium (5) is actually situated can be determined. Then, these regions of interest (110) can be illuminated in a second mode. Thus, no light which has not been coupled to the turbid medium (5) and which might cause overexposure of the detector unit of the imaging device (106) will reach the imaging device (106).

Abstract translation: 提供了用于光学检查混浊介质（5）内部的装置（1; 10; 20; 30; 40）。 该装置包括适于照射被检查的混浊介质（5）的照明系统（2; 12; 22; 32; 42）和适于从检测到的光产生图像的成像装置（106）。 照明系统（2; 12; 22; 32; 42）适于在至少第一模式中可操作，其中通过照亮混浊介质（5）和周围区域来获取广域图像。 可以从该广域图像确定混浊介质（5）实际位于的感兴趣区域（110）。 然后，可以以第二模式照亮这些感兴趣的区域（110）。 因此，没有与浑浊介质（5）耦合并且可能导致成像装置（106）的检测器单元过度曝光的光将不会到达成像装置（106）。

公开(公告)号：WO2010044003A2

公开(公告)日：2010-04-22

申请号：PCT/IB2009/054365

申请日：2009-10-06

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  VAN BEEK, Michael, C. ,  RENSEN, Wouter, H., J. ,  HARBERS, Rik

Inventor： VAN BEEK, Michael, C. ,  RENSEN, Wouter, H., J. ,  HARBERS, Rik

IPC: G01N21/47 ,  G01N21/49 ,  G01N21/59 ,  A61B5/00

CPC classification number: A61B5/0059 ,  A61B5/4528 ,  G01N21/4795 ,  G01N2201/0626 ,  G01N2201/0635 ,  G01N2201/0675 ,  G01N2201/124

Abstract: A device (1; 10; 20; 30; 40) for optically examining the interior of a turbid medium is provided. The device comprises an illumination system (2; 12; 22; 32; 42) adapted for illuminating a turbid medium to be examined and an imaging device (106) adapted for generating images from detected light. The illumination system (2; 12; 22; 32; 42) is adapted to be operable in at least a first mode in which a large area is illuminated and a second mode in which at least one selected region (110) of the large area is illuminated.

Abstract translation: 提供了一种用于光学检查混浊介质内部的装置（1; 10; 20; 30; 40）。 该装置包括适于照射要检查的混浊介质的照明系统（2; 12; 22; 32; 42）和适于从检测到的光产生图像的成像装置（106）。 照明系统（2; 12; 22; 32; 42）适于在其中照亮大面积的至少第一模式和第二模式中操作，其中大面积的至少一个选定区域（110） 被照亮。

公开(公告)号：WO2009007333A1

公开(公告)日：2009-01-15

申请号：PCT/EP2008/058734

申请日：2008-07-07

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  STOECKEL, Peter ,  BIEDENBENDER, Frank ,  KRUGER, Thomas

Inventor： STOECKEL, Peter ,  BIEDENBENDER, Frank ,  KRUGER, Thomas

IPC: G01N21/95 ,  B07C5/342 ,  B65B1/48

CPC classification number: G01N21/9508 ,  A61J3/074 ,  B07C5/3425 ,  G01F17/00 ,  G01N15/1463 ,  G01N21/274 ,  G01N2015/0096 ,  G01N2015/1497 ,  G01N2201/0694 ,  G01N2201/124 ,  G01N2201/12753 ,  G06T7/0006 ,  G06T2207/10024

Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Überwachung der Befüllung einer Kapsel mit einem Medikament, ein entsprechendes Befüllungsverfahren die zugehörigen Vorrichtungen, sowie ein Computerprogramm zur Steuerung des Verfahrens und der Vorrichtung. Bei dem Überwachungsverfahren wird, nachdem wenigstens ein Teil der Kapsel mit einer vorgegebenen Füllmasse von vorgegebener geschlossener Kontur aus dem Medikament befüllt wurde, in einem ersten Schritt wenigstens die im Teil der Kapsel nach der Befüllung befindliche Füllmasse digitalbildgebend aufgezeichnet, in einem zweiten Schritt aus der digitalbildgebenden Aufzeichnung die Kontur der im Teil der Kapsel befindlichen Füllmasse ermittelt und in einem dritten Schritt die Kontur analysiert wird, um eine Bewertung der Befüllung im Vergleich zur vorgegebenen Kontur vorzunehmen. Es ist erfindungsgemäß vorgesehen mittels Regelung des optischen Systems äußere Einflüsse auf die Bildeigenschaften auszugleichen.

Abstract translation: 本发明涉及一种用于监测胶囊的填充有药物，对应的填充过程中，相关联的装置，以及用于控制的方法和设备的计算机程序的方法。 在监控方法中，至少一个与预定的闭合轮廓从药物被数字填充成像的给定填充物质的胶囊的一部分后，记录位于灌装，在第一步骤中，至少后的胶囊的一部分的填充化合物，在从数字成像的第二步骤 是记录确定位于该胶囊的部分填充化合物的轮廓，并分析该轮廓在第三步骤中，以使相比于预定轮廓的填充的评估。 它根据通过光学系统方案提供了本发明补偿对图像特性的环境影响。

公开(公告)号：WO2007127909A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/067608

申请日：2007-04-27

Applicant: C8 MEDISENSORS INC. ,  LIPSON, Jan ,  LIPSON, Albert, L. ,  MCNAMARA, Robert, P.

Inventor： LIPSON, Jan ,  LIPSON, Albert, L. ,  MCNAMARA, Robert, P.

IPC: G01J3/00

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0289 ,  G01N21/4738 ,  G01N2021/4709 ,  G01N2021/4747 ,  G01N2021/656 ,  G01N2201/124

Abstract: An apparatus for enhancing the selectivity for spectroscopic measurements of analytes in a turbid medium is described. In one example, spatial filters are used to select only certain radii from the medium to be imaged. This selection is accomplished by placing an optical obstruction on the surface of the medium or at an image plane of the surface later in the optical imaging system. In one implementation, this is achieved by placing a fiber bundle at an image plane of the collecting optical system and then using a spacer of appropriate size at the center of the fiber bundle to act as a central obstruction.

Abstract translation: 描述了用于提高浑浊介质中分析物的光谱测量的选择性的装置。 在一个示例中，空间滤波器用于仅从要成像的介质中选择某些半径。 该选择通过在光学成像系统中稍后将光学障碍物放置在介质的表面或表面的像平面上来实现。 在一个实施方案中，这是通过将纤维束放置在收集光学系统的图像平面上，然后在纤维束的中心使用适当尺寸的间隔件来作为中心障碍物来实现的。

公开(公告)号：US11709126B2

公开(公告)日：2023-07-25

申请号：US17644074

申请日：2021-12-13

Applicant: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.

Inventor： Xiansuan Du ,  Yong Dai

IPC: G01N15/14 ,  G01N21/47 ,  G01N21/64 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N21/4738 ,  G01N21/6428 ,  G01N2015/0076 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2201/06113 ,  G01N2201/124

Abstract: A sample analyzer with an optical detection device and a sample analysis method of the sample analyzer are disclosed. The optical detection device includes a fluid chamber, a light source and a light detector. The fluid chamber includes an illumination zone. An analyte flows through the illumination zone so as to form a sample stream. The light source illuminates the illumination zone to excite cell articles, reacted with a reagent, of the sample stream to emit a light signal. The light detector detects the fluorescent lights and transforms it into an electric signal. The light detector can include a silicon photomultiplier.

公开(公告)号：US20170315046A1

公开(公告)日：2017-11-02

申请号：US15163541

申请日：2016-05-24

Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Xiansuan DU ,  Yong DAI

IPC: G01N15/14 ,  G01N21/64 ,  G01N21/47 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N21/4738 ,  G01N21/6428 ,  G01N2015/0076 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2201/06113 ,  G01N2201/124

Abstract: A sample analyzer with an optical detection device and a sample analysis method of the sample analyzer are disclosed. The optical detection device includes a fluid chamber, a light source and a light detector. The fluid chamber includes an illumination zone. An analyte flows through the illumination zone so as to form a sample stream. The light source illuminates the illumination zone to excite cell articles, reacted with a reagent, of the sample stream to emit a light signal. The light detector detects the fluorescent lights and transforms it into an electric signal. The light detector can include a silicon photomultiplier.