公开(公告)号：US20040119974A1

公开(公告)日：2004-06-24

申请号：US10326524

申请日：2002-12-20

Inventor： James E. Bishop ,  Sunil S. Dalal ,  Zhenxiang Gong ,  Michael D. Lock

IPC: G01N021/64

CPC classification number: G01N21/6428 ,  G01N15/1459 ,  G01N2021/6441 ,  G01N2201/1241

Abstract: The present invention provides instruments for analyzing a multiplicity of fluorescent dyes using a multiplicity of amplifying photodetectors, methods for using the instruments, methods for setting the instrument parameters, and methods for resetting the instrument parameters following a changed in photodetector amplification. The present invention is particularly applicable in the field of flow cytometry.

Abstract translation: 本发明提供了使用多个放大光电检测器分析多种荧光染料的仪器，使用仪器的方法，用于设置仪器参数的方法以及在光电检测器放大变化之后复位仪器参数的方法。 本发明特别适用于流式细胞仪领域。

公开(公告)号：US5051901A

公开(公告)日：1991-09-24

申请号：US570078

申请日：1990-08-20

Applicant: Hirotoshi Endo

Inventor： Hirotoshi Endo

IPC: G01N21/75 ,  G01N21/78 ,  G01N21/86 ,  G01N33/48

CPC classification number: G01N21/8483 ,  G01N33/48 ,  G01N2201/122 ,  G01N2201/1241 ,  G01N2201/127

Abstract: Errors in applying liquid sample are judged during biochemical analysis wherein a droplet of liquid sample is applied to an analysis medium containing a reagent, which chemically reacts with a specific constitutent in the liquid sample, the analysis medium is then incubated, the optical densities of the analysis medium are determined, and concentration of the specific constituent in the liquid sample is determined from the optical densities of the analysis medium thus determined. The method for judging errors in applying a liquid sample comprises the steps of determining the optical density of the analysis medium plural times with the passage of time while the analysis medium is being incubated, and calculating the difference between the maximum value and the minimum value of the optical densities thus determined for the analysis medium. The difference is compared with a predetermined threshold value. In cases the difference is smaller than the threshold value, it is judged that errors occurred in applying a liquid sample to the analysis medium.

Abstract translation: 在生物化学分析中判断应用液体样品的错误，其中将液体样品液滴施加到含有与液体样品中的特定成分发生化学反应的试剂的分析介质上，然后将分析介质温育， 确定分析介质，并根据如此确定的分析介质的光密度确定液体样品中特定成分的浓度。 用于判断应用液体样品的误差的方法包括以下步骤：在分析介质被培养的同时，随着时间的推移多次确定分析介质的光密度，并计算最大值与最小值之差 因此为分析介质确定的光密度。 将该差异与预定阈值进行比较。 在差异小于阈值的情况下，判定在将液体样品应用于分析介质时发生错误。

公开(公告)号：US09897545B2

公开(公告)日：2018-02-20

申请号：US15045464

申请日：2016-02-17

Applicant: GLORY LTD.

Inventor： Takeshi Sato

IPC: G01N21/64 ,  G01N21/86 ,  G07D7/12 ,  G01J1/46 ,  G06Q10/08 ,  G07D7/1205 ,  B41M3/14 ,  D21H21/48 ,  B42D25/29

CPC classification number: G01N21/645 ,  B41M3/144 ,  B42D25/29 ,  B42D25/387 ,  D21H21/48 ,  G01J1/46 ,  G01N21/6408 ,  G01N21/643 ,  G01N21/86 ,  G01N2021/6413 ,  G01N2021/6421 ,  G01N2021/8645 ,  G01N2021/8663 ,  G01N2201/0621 ,  G01N2201/12 ,  G01N2201/1241 ,  G06Q10/0875 ,  G07D7/12 ,  G07D7/1205

Abstract: A fluorescence and phosphorescence detection device includes a fluorescence and phosphorescence sensor, a data acquiring unit, and an emission detection unit. The fluorescence and phosphorescence sensor includes a light source that emits an excitation light of a predetermined wavelength, and a photodetection unit that detects fluorescence emission and phosphorescence emission excited from the paper sheet by the excitation light. The data acquiring unit acquires a time-series waveform of a signal outputted from the fluorescence and phosphorescence sensor in response to the detection of the emission in the photodetection unit. The emission detection unit detects the fluorescence emission from the time-series waveform of a period in which the excitation light is emitted from the light source and detects the phosphorescence emission from an attenuation curve appearing on the time-series waveform of a period in which emission of the excitation light from the light source is stopped.

公开(公告)号：US20170167985A1

公开(公告)日：2017-06-15

申请号：US15374859

申请日：2016-12-09

Applicant: Samsung Electronics Co., Ltd

Inventor： Beom Seok Lee ,  Sung Ha Park ,  Kyung-Mi Song ,  Sang Hyun Lee ,  Chung Ung Kim

IPC: G01N21/80 ,  G01N33/487 ,  G01N33/84

CPC classification number: G01N21/80 ,  G01N31/221 ,  G01N33/48785 ,  G01N33/84 ,  G01N2021/7793 ,  G01N2201/1241

Abstract: Disclosed herein are specimen analysis apparatus and method of analyzing specimen using the same. The specimen analysis apparatus includes a cartridge configured to accommodate at least three pH indicators having different properties and an analyzer configured to determine whether a specimen is acidic or basic using one of the pH indicators. The analyzer determines a pH measurement value using another pH indicator selected based on whether the specimen is acidic or basic.

公开(公告)号：US20160238529A1

公开(公告)日：2016-08-18

申请号：US15045464

申请日：2016-02-17

Applicant: GLORY LTD.

Inventor： Takeshi SATO

IPC: G01N21/64

CPC classification number: G01N21/645 ,  B41M3/144 ,  B42D25/29 ,  B42D25/387 ,  D21H21/48 ,  G01J1/46 ,  G01N21/6408 ,  G01N21/643 ,  G01N21/86 ,  G01N2021/6413 ,  G01N2021/6421 ,  G01N2021/8645 ,  G01N2021/8663 ,  G01N2201/0621 ,  G01N2201/12 ,  G01N2201/1241 ,  G06Q10/0875 ,  G07D7/12 ,  G07D7/1205

Abstract: A fluorescence and phosphorescence detection device includes a fluorescence and phosphorescence sensor, a data acquiring unit, and an emission detection unit. The fluorescence and phosphorescence sensor includes a light source that emits an excitation light of a predetermined wavelength, and a photodetection unit that detects fluorescence emission and phosphorescence emission excited from the paper sheet by the excitation light. The data acquiring unit acquires a time-series waveform of a signal outputted from the fluorescence and phosphorescence sensor in response to the detection of the emission in the photodetection unit. The emission detection unit detects the fluorescence emission from the time-series waveform of a period in which the excitation light is emitted from the light source and detects the phosphorescence emission from an attenuation curve appearing on the time-series waveform of a period in which emission of the excitation light from the light source is stopped.

Abstract translation: 荧光和磷光检测装置包括荧光和磷光传感器，数据获取单元和发射检测单元。 荧光和磷光传感器包括发射预定波长的激发光的光源和检测由激发光从纸张激发的荧光发射和磷光发射的光检测单元。 数据获取单元响应于光检测单元中的发射的检测，获取从荧光和磷光传感器输出的信号的时间序列波形。 发光检测单元从从光源发射激发光的时间段的时间序列波形检测荧光发射，并且从出现在发光的周期的时间序列波形上的衰减曲线检测磷光发射 来自光源的激发光被停止。

公开(公告)号：US20160061742A1

公开(公告)日：2016-03-03

申请号：US14784764

申请日：2014-04-15

Applicant: DRÄGER SAFETY AG & CO. KGAA

Inventor： Philipp ROSTALSKI ,  Hans-Ullrich HANSMANN ,  Andreas MOHRMANN ,  Arne TRÖLLSCH ,  Karsten HILTAWSKY

IPC: G01N21/78 ,  G01N31/22 ,  G01N21/27 ,  G01N33/00

CPC classification number: G01N21/783 ,  G01N21/272 ,  G01N31/223 ,  G01N33/0013 ,  G01N33/0031 ,  G01N33/0073 ,  G01N2201/1241 ,  G01N2201/1242 ,  G01N2201/1248

Abstract: A measuring device (10) and a measurement method measure a concentration of gaseous/aerosol components of a gas mixture. A reaction carrier (14) has a flow channel (42) defining a reaction chamber (46) having a optically detectable reaction material (48), that reacts with a gas mixture component or with a reaction product. The measuring device (12) includes a gas-conveying assembly (2) with a gas-conveying apparatus (28) conveying the gas mixture and a detection assembly (3), which has a lighting apparatus (37) for lighting the reaction chamber (46), an optical sensor (38) for sensing the optically detectable reaction, and an evaluating unit (4) evaluating sensor data and determining a concentration of the component of the gas mixture. The detection assembly (3) senses a speed of a reaction front (6) propagating in the flow direction in the reaction chamber (46) and determines a preliminary concentration from the speed of the reaction front (6).

Abstract translation: 测量装置（10）和测量方法测量气体混合物的气体/气溶胶组分的浓度。 反应载体（14）具有限定具有光学可检测反应材料（48）的反应室（46）的流动通道（42），其与气体混合物组分或与反应产物反应。 测量装置（12）包括具有输送气体混合物的气体输送装置（28）和检测组件（3）的气体输送组件（2），该检测组件具有用于点亮反应室的照明装置（37） 46），用于感测可光学检测的反应的光学传感器（38），以及评估传感器数据和确定气体混合物的组分浓度的评估单元（4）。 检测组件（3）感测在反应室（46）中沿流动方向传播的反应前沿（6）的速度，并根据反应前沿（6）的速度确定初步浓度。

公开(公告)号：US08314930B2

公开(公告)日：2012-11-20

申请号：US12941432

申请日：2010-11-08

Applicant: Koichi Taniguchi ,  Masayuki Ochi ,  Shuichi Chikamatsu ,  Shigehisa Nozawa

Inventor： Koichi Taniguchi ,  Masayuki Ochi ,  Shuichi Chikamatsu ,  Shigehisa Nozawa

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N2021/8887 ,  G01N2021/8896 ,  G01N2201/1241

Abstract: An inspection device for inspecting defects of an inspection object including a light source for irradiating a luminous flux to the inspection object; an optical system for guiding reflected light from the inspection object; a photoelectric image sensor having a plurality of photoelectric cells arranged, for converting the light guided to detection signals; a detection signal transfer unit having channels each constituted by a signal correction unit, a converter and an image formation unit, and corresponding to each of a plurality of regions formed by dividing the photoelectric image sensor, respectively; and an image synthesis unit for forming an image of the surface of the object by synthesizing partial images outputted; the inspection device inspecting defects of the object by processing the synthesized image; whereby it becomes possible to correct a detection signal from said photoelectric cell close to a predetermined reference target value.

Abstract translation: 一种检查装置，用于检查包括用于向检查对象照射光通量的光源的检查对象的缺陷; 用于引导来自检查对象的反射光的光学系统; 光电图像传感器，其具有布置用于将被引导的光转换成检测信号的多个光电单元; 检测信号传送单元，其具有各自由信号校正单元，转换器和图像形成单元构成的信道，并且分别对应于通过划分光电图像传感器形成的多个区域中的每一个; 以及图像合成单元，通过合成输出的部分图像来形成对象的表面的图像; 检查装置通过处理合成图像来检查物体的缺陷; 从而可以将来自所述光电单元的检测信号校正为接近预定的基准目标值。

公开(公告)号：US08035071B2

公开(公告)日：2011-10-11

申请号：US12116241

申请日：2008-05-07

Applicant: Masami Makuuchi ,  Ritsurou Orihashi ,  Masayoshi Takahashi ,  Wen Li ,  Kengo Imagawa ,  Takahiro Jingu

Inventor： Masami Makuuchi ,  Ritsurou Orihashi ,  Masayoshi Takahashi ,  Wen Li ,  Kengo Imagawa ,  Takahiro Jingu

IPC: G01N21/88

CPC classification number: G01N21/9501 ,  G01N21/94 ,  G01N2201/1241

Abstract: The detection part has: a subtraction module for calculating correction data from data of detection systems when a reference-voltage generation module applies a reference voltage to the detection systems; a data-holding module for holding the correction data; an addition module for making a correction of detection data; a comparison module for comparing the detection data with switching data; and a selector for switching data of the detection systems including data subjected to the correction according to the output of the comparison module.

Abstract translation: 检测部具有：减法模块，用于当参考电压产生模块向检测系统施加参考电压时，从检测系统的数据计算校正数据; 用于保持校正数据的数据保持模块; 用于对检测数据进行校正的加法模块; 比较模块，用于将检测数据与切换数据进行比较; 以及选择器，用于根据比较模块的输出来切换包括经过校正的数据的检测系统的数据。

公开(公告)号：US07067791B2

公开(公告)日：2006-06-27

申请号：US11059740

申请日：2005-02-17

Applicant: Dmitry M. Sagatelyan ,  Tor Slettnes

Inventor： Dmitry M. Sagatelyan ,  Tor Slettnes

IPC: H01J40/14

CPC classification number: G01N21/274 ,  G01J1/42 ,  G01N21/645 ,  G01N2201/1241 ,  H03F3/08 ,  H04N5/235 ,  H04N5/2353 ,  H04N5/2355 ,  H04N5/243 ,  H04N5/35581

Abstract: A photo-detector generated signal is measured as a sample set comprising a long signal and a short signal. The short signal is scaled to the value of the long signal if the long signal exceeds a dynamic range associated with the photo detector. In one embodiment, the short signal is obtained during a short time interval that is at the approximate middle of a long time interval such that the short and long intervals share a common median time value. Given such symmetry, an approximately linear signal yields a proportionality parameter between the long and short signals thereby allowing the short signal to be scaled. The proportionality parameter facilitates determination of an integration independent component of the photo detector signal that should be removed from the measured long and short signals before scaling. A plurality of sample sets can also be processed such that each sample set overlaps with its neighboring sample set, thereby increasing the effective number of sample sets.

Abstract translation: 光检测器产生的信号被测量为包括长信号和短信号的样本集。 如果长信号超过与光电检测器相关联的动态范围，则短信号被缩放到长信号的值。 在一个实施例中，在短时间间隔内获得短信号，该短时间间隔在长时间间隔的大致中间处，使得短间隔和长间隔共享公共中值时间值。 给定这种对称性，近似线性的信号在长信号和短信号之间产生比例参数，从而允许短信号被缩放。 比例参数有助于确定光电探测器信号的积分独立分量，该分量在缩放之前应从测量的长信号和短信号中去除。 也可以处理多个样本集，使得每个样本集合与其相邻样本集重叠，从而增加样本集合的有效数量。

公开(公告)号：US20040121483A1

公开(公告)日：2004-06-24

申请号：US10328109

申请日：2002-12-23

Inventor： John F. Corson ,  Scott D. Connell ,  Srinka Ghosh

IPC: G01N021/64

CPC classification number: G01N21/6452 ,  G01N21/6428 ,  G01N2201/1241

Abstract: Biopolymeric array scanners that are capable of automatically selecting a dye specific scale factor to employ for a plurality of different dyes, as wells as methods for making and using the same, are provided. In many embodiments, the actual dye specific scale factor automatically selected by the scanner is one that is equal to a preset nullmasternull scale factor, so that the scanner reads any supported dye using the same constant scale factor. The dye, specific scale factor selection is typically made by reference to a collection of nominal scale factors for each member of the plurality of dyes. In using the subject scanners, a user simply inputs the one or more dyes being used in a given array assay, and the scanner automatically reads the array using an automatically chosen dye specific scale factor for the selected dyes. Also provided are methods of obtaining collections of nominal scale factors and computer readable mediums comprising the same. The subject invention finds use in a variety of different applications, including both genomics and proteomics applications.

Abstract translation: 提供了能够自动选择染料比例因子以用于多种不同染料的生物聚合物阵列扫描仪，作为制备和使用它们的方法的孔。 在许多实施例中，由扫描仪自动选择的实际染料特异性比例因子等于预设的“主”比例因子，使得扫描器使用相同的恒定比例因子读取任何支持的染料。 染料，比例因子选择通常参考多个染料中每个成员的标称比例因子的集合来进行。 在使用主题扫描仪时，用户只需输入在给定阵列测定中使用的一种或多种染料，并且扫描仪使用所选染料的自动选择的染料比例因子自动读取阵列。 还提供了获得标称比例因子的集合的方法以及包括其的计算机可读介质。 本发明可用于各种不同的应用，包括基因组学和蛋白质组学应用。