公开(公告)号：US08519337B2

公开(公告)日：2013-08-27

申请号：US12164017

申请日：2008-06-28

Applicant: Paul Shelley ,  Greg Werner ,  Paul Vahey

Inventor： Paul Shelley ,  Greg Werner ,  Paul Vahey

IPC: G01N21/3581 ,  G01N21/35

CPC classification number: G01N21/359 ,  G01N21/274 ,  G01N21/278 ,  G01N21/3563 ,  G01N21/8422 ,  G01N2021/8472 ,  G01N2201/129

Abstract: A method of determining a physical property of a composite material includes providing a series of composite materials surfacing films, which are subjected to increasing thermal experience to create a set of thermal effect standards, collecting near-IR spectra on those standards, performing data pre-processing and then multivariate calibration on the spectra of the composite materials surfacing films, and using that calibration to predict the thermal effect for samples in question.

Abstract translation: 确定复合材料的物理性能的方法包括提供一系列复合材料表面膜，其经受增加的热经验以产生一组热效应标准，在这些标准上收集近红外光谱，执行数据预处理， 对复合材料表面膜的光谱进行处理，然后进行多元校准，并使用该校准来预测所讨论样品的热效应。

公开(公告)号：US08502972B2

公开(公告)日：2013-08-06

申请号：US12811166

申请日：2008-12-25

Applicant: Michael Himmelhaus ,  Alexandre Francois

Inventor： Michael Himmelhaus ,  Alexandre Francois

IPC: G01N21/31

CPC classification number: G01N21/7703 ,  G01N21/05 ,  G01N21/274 ,  G01N21/648 ,  G01N2021/0346 ,  G01N2021/7789 ,  G01N2201/129

Abstract: A method for sensing a target object using optical mode excitations in microresonators, comprises: preparing at least one cluster including at least two microresonators; obtaining some first spectra of the cluster; adsorbing the target object on a surface of the cluster; obtaining some second spectra of the cluster; and sensing the target object by comparing a lineshape of the first spectra with a lineshape of the second spectra.

Abstract translation: 一种用于在微谐振器中使用光学模式激励来感测目标物体的方法，包括：制备至少一个包括至少两个微谐振器的簇; 获得集群的一些第一个光谱; 将所述目标物体吸附在所述簇的表面上; 获得集群的一些第二个光谱; 并且通过将第一光谱的线形与第二光谱的线形比较来感测目标对象。

公开(公告)号：US08416405B2

公开(公告)日：2013-04-09

申请号：US12537671

申请日：2009-08-07

Applicant: Janice Panza ,  John Maier

Inventor： Janice Panza ,  John Maier

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/65 ,  G01N2201/129

Abstract: A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. The spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device.

Abstract translation: 一种确定生物组织样品或药物递送装置的属性的系统和方法。 用基本单色光照射样品，从而产生拉曼散射光子。 评估拉曼散射光子，从而产生光谱数据集，其中所述光谱数据集包括拉曼光谱和空间上准确的波长分辨图像中的至少一个。 评估光谱数据集以确定生物组织样品和药物递送装置的属性中的至少一个。 在一个实施方案中，生物组织包含动脉组织。 在另一个实施方案中，药物递送装置是药物洗脱支架。 在另一个实施方案中，拉曼化学成像可用于评估样品并鉴定组织，药物，药物递送装置和与药物递送装置相关联的基质中的至少一种。

公开(公告)号：US08402326B2

公开(公告)日：2013-03-19

申请号：US13306642

申请日：2011-11-29

Applicant: Anant Pratap Singh

Inventor： Anant Pratap Singh

IPC: G11C29/00

CPC classification number: G11C29/846 ,  G01N2201/129 ,  G06F11/1048 ,  G11C7/1006 ,  G11C2029/0409 ,  G11C2207/104

Abstract: An integrated circuit device comprising a memory cell array having a plurality of memory cells arranged in a matrix of rows and columns; multiplexer circuitry, coupled to the memory cell array, comprising a plurality of data multiplexers, each data multiplexer having a plurality of inputs, comprising (i) a first input to receive write data which is representative of data to be written into the memory cells of the memory cell array in response to a write operation, and (ii) a second input to receive read data which is representative of data read from memory cells of the memory cell array, and an associated output to responsively output data from one of the plurality of inputs; and syndrome generation circuitry, coupled to the multiplexer circuitry, to generate: (i) a write data syndrome vector using the write data and (ii) a read data syndrome vector using the read data.

Abstract translation: 一种集成电路装置，包括具有排列成行和列的矩阵的多个存储单元的存储单元阵列; 多路复用器电路，耦合到存储单元阵列，包括多个数据多路复用器，每个数据多路复用器具有多个输入，包括：（i）第一输入端，用于接收写入数据，该数据代表要写入存储单元的 所述存储单元阵列响应于写入操作，以及（ii）第二输入端，用于接收表示从所述存储单元阵列的存储器单元读取的数据的读取数据，以及相关联的输出以响应于从所述多个存储单元阵列中的一个输出数据 的投入; 以及耦合到所述多路复用器电路的校正子产生电路，以产生：（i）使用所述写数据的写数据校正子向量，以及（ii）使用所述读数据的读数据校正子向量。

公开(公告)号：US20130003044A1

公开(公告)日：2013-01-03

申请号：US13541171

申请日：2012-07-03

Applicant: John Maier ,  Jeffrey Cohen ,  Ryan Priore

Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

IPC: G01J3/28 ,  G01J3/44

CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

公开(公告)号：US08344334B2

公开(公告)日：2013-01-01

申请号：US12681863

申请日：2008-09-22

Applicant: Raymond Douglas Coker ,  John Tetteh ,  Michael Paul Andreou

Inventor： Raymond Douglas Coker ,  John Tetteh ,  Michael Paul Andreou

IPC: G01N21/64

CPC classification number: G01N21/65 ,  G01N21/64 ,  G01N21/658 ,  G01N33/02 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2201/129

Abstract: A method for the detection or determination of a target comprising a plurality of target compounds, or derivatised target compounds, said method comprising: immobilizing said target on a carrier, directing radiation at said target, said radiation being selected to cause said target to emit a relevant radiation, detecting said relevant radiation emitted by said target, and analyzing said detected radiation to identify and/or quantify the plurality of target compounds in said target.

Abstract translation: 一种用于检测或测定包含多种目标化合物或衍生化的靶化合物的靶的方法，所述方法包括：将所述靶固定在载体上，引导所述靶上的辐射，选择所述辐射使所述靶发射 相关辐射，检测由所述目标发射的相关辐射，并分析所述检测到的辐射以识别和/或定量所述靶中的多个目标化合物。

公开(公告)号：US20120228199A1

公开(公告)日：2012-09-13

申请号：US13481028

申请日：2012-05-25

Applicant: Steven H. Modiano ,  Kevin L. Deppermann ,  James Crain ,  Sam R. Eathington ,  Mike Graham

Inventor： Steven H. Modiano ,  Kevin L. Deppermann ,  James Crain ,  Sam R. Eathington ,  Mike Graham

IPC: B07C5/00 ,  G01J3/46 ,  G01B11/24 ,  G01N21/55

CPC classification number: G06K9/00 ,  B07C5/00 ,  B07C5/10 ,  B07C5/34 ,  B07C5/3422 ,  B07C5/3425 ,  G01J3/0218 ,  G01J3/10 ,  G01N21/253 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/85 ,  G01N2021/0339 ,  G01N2021/8592 ,  G01N2201/0627 ,  G01N2201/129

Abstract: Systems and methods are provided for evaluating and sorting seeds based on characteristics of the seeds. One system includes an imaging and analysis subsystem that collects image data from the seeds and analyzes the collected image data for characteristics of the seeds. This subsystem can include an imaging theater having minors that reflect image data from the seeds to an imaging device for collection. The system can also include an off-loading and sorting subsystem configured to sort the seeds based on their characteristics. And, one method includes illuminating the seeds and collecting image data from the seeds for determining their characteristics. The image data can be collected from at least three portions of the seeds at each of a plurality of sequentially changing spectral wavelengths. In addition (or alternatively), the image data can be collected from top and bottom portions of the seeds using a single imaging device.

Abstract translation: 提供的系统和方法用于根据种子的特征来评估和分选种子。 一个系统包括成像和分析子系统，其从种子收集图像数据，并分析所收集的图像数据以获得种子的特征。 该子系统可以包括具有将来自种子的图像数据反映到用于收集的成像装置的未成年人的成像影院。 该系统还可以包括卸载和排序子系统，其被配置为基于其特征对种子进行分类。 并且，一种方法包括照亮种子并从种子收集图像数据以确定其特性。 可以从多个顺序变化的光谱波长中的每一个的种子的至少三个部分收集图像数据。 另外（或替代地），可以使用单个成像装置从种子的顶部和底部收集图像数据。

公开(公告)号：US08194245B2

公开(公告)日：2012-06-05

申请号：US12907597

申请日：2010-10-19

Applicant: Gerard Hotier ,  Philibert Leflaive ,  Mathieu Digne ,  Philippe Marteau ,  Jean-Lucien Molle ,  Michel Leclercq ,  Sophie Dewally-Morel

Inventor： Gerard Hotier ,  Philibert Leflaive ,  Mathieu Digne ,  Philippe Marteau ,  Jean-Lucien Molle ,  Michel Leclercq ,  Sophie Dewally-Morel

IPC: G01J3/44

CPC classification number: G01N21/65 ,  B01D15/1821 ,  G01N21/8507 ,  G01N2201/084 ,  G01N2201/1211 ,  G01N2201/129

Abstract: The present invention describes a method for measuring the concentrations of species present at one point of a separation unit functioning in simulated moving bed mode (SMB), using an immersing probe located at one point in the unit or on one of the streams entering or leaving said unit, and a thermocouple located in the vicinity of the immersing probe, in which a Raman spectrum obtained using a laser source functioning at a wavelength of 785 nm is utilized.

Abstract translation: 本发明描述了一种用于测量存在于模拟移动床模式（SMB）中运行的分离单元的一个点处的物种的浓度的方法，其使用位于该单元中的一个点处的浸入探针或者进入或离开的一个流 所述单元和位于浸渍探头附近的热电偶，其中使用使用波长为785nm的激光源获得的拉曼光谱。

公开(公告)号：US20120123681A1

公开(公告)日：2012-05-17

申请号：US13139969

申请日：2009-10-14

Applicant: Debora Marcondes Bastos Pereira Milori ,  Ladislau Martin Neto ,  Ednaldo Jose Ferreira ,  Ana Flavia Zaghi ,  Andre Leonardo Venancio

Inventor： Debora Marcondes Bastos Pereira Milori ,  Ladislau Martin Neto ,  Ednaldo Jose Ferreira ,  Ana Flavia Zaghi ,  Andre Leonardo Venancio

IPC: G06F19/00 ,  G01N21/64 ,  G01N21/25

CPC classification number: G01N21/6486 ,  G01N33/0098 ,  G01N2021/6421 ,  G01N2201/129

Abstract: The present invention relates to a method, apparatus and a system of fast diagnosis of stresses and diseases in higher plants. The proposed methodology is based on the hypothesis of that when a plant is in imbalance; there are changes in its metabolism that render an alteration of the chemical composition of its organs. This chemical alteration leads to a change in the physical properties, such as the fluorescence of the leaves. Due to the complexity of the material of the leaves, the present method proposes that the signal be treated with statistical methods and that the classification is made through softwares based on machine learning. As an example of the application of the invention, the results are shown for the Greening disease in citrus. Currently, Greening is the most severe citrus disease since there is no treatment available for it and due to its high dissemination rate and the fact that it affects all varieties of orange trees, being the diagnosis performed through visual inspection, which renders high subjectivity, high error percentage and the disease is only diagnosed after the expression of the symptoms (˜8 months). During the asymptomatic phase, the infected tree is a source of dissemination of the disease. The present invention can perform the asymptomatic diagnosis of Greening disease from the leaf with a percentage of correct diagnosis higher than 80%.

Abstract translation: 本发明涉及高等植物中应力和疾病快速诊断的方法，装置和系统。 所提出的方法是基于当植物不平衡时的假设; 其代谢改变会改变其器官的化学成分。 这种化学变化导致物理性质的改变，例如叶子的荧光。 由于叶片材料的复杂性，本方法建议采用统计方法对信号进行处理，并通过基于机器学习的软件进行分类。 作为本发明的应用的实例，结果显示了柑橘中的绿化病。 目前，绿化是最严重的柑橘病，因为没有可用的治疗方法，由于其传播率高，影响所有品种的橙树，是通过目视检查进行的诊断，其主观性高，高 错误百分比，疾病仅在症状表达后诊断（〜8个月）。 在无症状期间，感染的树是疾病的传播来源。 本发明可以从正确诊断率高于80％的叶中进行绿色疾病的无症状诊断。

公开(公告)号：US08159656B2

公开(公告)日：2012-04-17

申请号：US12443849

申请日：2007-10-04

Applicant: Yoshimasa Miura ,  Masayuki Shirao ,  Takashi Ohmori ,  Takuya Saiwaki

Inventor： Yoshimasa Miura ,  Masayuki Shirao ,  Takashi Ohmori ,  Takuya Saiwaki

IPC: G01J3/00

CPC classification number: G01N21/33 ,  G01N2201/129

Abstract: A first step of measuring a change over time in the spectral transmission spectrum of a measurement sample by its exposure to the light of a light source including an ultraviolet radiation for a preset light exposure time, a second step of performing a correction according to the change over time in the spectral transmission spectrum of the measurement sample based on the result of the measurement obtained by the first step, and a third step of calculating the final in vitro predicted SPF of the measurement sample using the result of the correction obtained by the second step are included.

Abstract translation: 第一步骤，通过对包含紫外线的光源的光的曝光来测量测量样本的光谱透射光谱随时间的变化，以达到预设的曝光时间;第二步骤，根据变化执行校正 基于由第一步骤获得的测量结果在测量样本的光谱透射光谱中随时间推移的第三步骤，以及使用由第二步获得的校正结果计算测量样品的最终体外预测SPF的第三步骤 包括步骤。