公开(公告)号：KR1020050022251A

公开(公告)日：2005-03-07

申请号：KR1020040020401

申请日：2004-03-25

Applicant: (주)아모레퍼시픽

Inventor： 노호식 ,  백흥수 ,  김수정 ,  채병근 ,  이병석 ,  김배환 ,  최규호 ,  손의동 ,  이해광 ,  김덕희 ,  장이섭 ,  이옥섭

IPC: C07C239/14

Abstract: PURPOSE: Provided are a hydroxamic acid derivative which shows an antiaging effect and is improved in safety and stability to the skin stimulus and discoloration, its preparation method, and an antiaging skin preparation for external use and a collagenase and elastase expression inhibitor containing the derivative. CONSTITUTION: The hydroxamic acid derivative is represented by the formula 1, wherein R1 and R2 are H, a C1-C10 alkyl group or a C3-C6 cycloalkyl group; R3 is CONH, NHCO, CONR5 or NR5CO (wherein R5 is H or a C1-C10 alkyl group); and R4 is -(CH)n- (wherein n is 0 or 1). The method comprises the steps of reacting benzoic acid and methyl 4-aminobenzoate or 4-aminophenylacetic acid methyl ester or reacting aniline and monomethyl terephthalate, to prepare a benzamide compound; substituting the amino bond of the benzamide compound into an alkyl bond; hydrolyzing the methyl ester group to prepare an acid; and reacting the obtained acid with hydroxyl amine·HCl salt to prepare the hydroxamic acid derivative of the formula 1.

Abstract translation: 目的：提供一种异羟肟酸衍生物，其表现出抗衰老作用，并且改善了皮肤刺激和变色的安全性和稳定性，其制备方法和外用抗衰老皮肤制剂以及含有该衍生物的胶原酶和弹性蛋白酶表达抑制剂。 构成：异羟肟酸衍生物由式1表示，其中R 1和R 2是H，C 1 -C 10烷基或C 3 -C 6环烷基; R3是CONH，NHCO，CONR5或NR5CO（其中R5是H或C1-C10烷基）; 且R 4为 - （CH）n - （其中n为0或1）。 该方法包括使苯甲酸和4-氨基苯甲酸甲酯或4-氨基苯乙酸甲酯或苯胺与对苯二甲酸单甲酯反应制备苯甲酰胺化合物的步骤; 将苯甲酰胺化合物的氨基取代成烷基键; 水解甲基酯以制备酸; 并使所得酸与羟胺·HCl盐反应制备式1的异羟肟酸衍生物。

公开(公告)号：KR1020040059270A

公开(公告)日：2004-07-05

申请号：KR1020020085863

申请日：2002-12-28

Applicant: (주)아모레퍼시픽

Inventor： 염명훈 ,  이종찬 ,  우광식 ,  강승현 ,  주경미 ,  김덕희 ,  장이섭

IPC: C08H7/00

Abstract: PURPOSE: A method for preparing secoisolariciresinol is provided to obtain a cosmetic composition having good absorptivity to the user's skin and excellent activity of inhibiting the formation of reactive oxygen species. CONSTITUTION: The method for preparing secoisolariciresinol comprises hydrolyzing flaxseed extract or secoisolariciresinol diglucoside separated therefrom. The hydrolysis is an acidic hydrolysis, alkaline hydrolysis or enzymatic hydrolysis. More particularly, the enzyme used in the enzymatic hydrolysis is selected from the group consisting of exo-glycolases and composite enzymes containing exo-glycolases. Further, the cosmetic composition contains the secoisolariciresinol in an amount of 0.0001 to 10 wt% based on the total weight of the composition.

Abstract translation: 目的：提供一种制备双异吲哚林醇的方法，以获得对使用者皮肤具有良好吸收性的化妆品组合物和抑制活性氧形成的优异活性。 构成：制备二异喹啉的方法包括水解亚麻籽提取物或与其分离的二异辛烯二醇二葡萄糖苷。 水解是酸性水解，碱性水解或酶水解。 更具体地，酶水解中使用的酶选自外消旋酶和含有外消旋酶的复合酶。 此外，化妆品组合物含有相对于组合物总重量为0.0001〜10重量％的二异辛烯硫酚。

公开(公告)号：KR1020030071009A

公开(公告)日：2003-09-03

申请号：KR1020020010512

申请日：2002-02-27

Applicant: (주)아모레퍼시픽

Inventor： 노호식 ,  김덕희

IPC: C07D311/72

Abstract: PURPOSE: Tocopherol derivatives having antioxidant effect, a preparation method thereof, and a cosmetic composition containing the same are provided, thereby preventing aging of the skin. CONSTITUTION: Tocopherol derivatives represented by the formula (I) are provided, wherein R1, R2 and R3 are H or methyl, and have at least one methyl at 5, 7 or 8 site of tocopherol; A is CH2-CH(CH3)- or CH=C(CH3)-; R4 is CH2-CH2, CH=CH, CH2-CH2-CH2, CH2-CH(CH3)-CH2 or CH2-C(CH3)2-CH2; and R5 is diethanol amine, tris hydroxy amine or N-methyl glucamine. A method for preparing the tocopherol derivatives of the formula (I) comprises the steps of: (A) reacting tocopherol with anhydrous dicarboxylic acid in the presence of organic salt using organic base to prepare tocopherol carboxylic acid ester; (B) chlorination of the tocopherol carboxylic acid ester to prepare tocopherol dicarboxylic acid chloride; and (C) reacting the tocopherol dicarboxylic acid chloride with amine to prepare amide compounds.

Abstract translation: 目的：提供具有抗氧化作用的生育酚衍生物，其制备方法和含有该生物调节剂的化妆品组合物，从而防止皮肤老化。 构成：提供由式（I）表示的生育酚衍生物，其中R 1，R 2和R 3为H或甲基，并且在5,7或8位生育酚具有至少一个甲基; A是CH 2 -CH（CH 3） - 或CH = C（CH 3） - ; R 4是CH 2 -CH 2，CH = CH，CH 2 -CH 2 -CH 2，CH 2 -CH（CH 3）-CH 2或CH 2 -C（CH 3）2 -CH 2; R5是二乙醇胺，三羟基胺或N-甲基葡糖胺。 制备式（I）的生育酚衍生物的方法包括以下步骤：（A）使用有机碱在有机盐存在下使生育酚与无水二羧酸反应以制备生育酚羧酸酯; （B）生育酚羧酸酯的氯化制备生育酚二羧酰氯; 和（C）使生育酚二酰氯与胺反应以制备酰胺化合物。